How to measure and interpret glucose in neonates

Marcus, Claude

doi:10.1080/080352501316978002

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…In addition, blood glucose measurements using dipsticks are not sufficiently reliable to establish the diagnosis [25]; however, in our study, there was a strong correlation between capillary glycaemia and baseline blood glucose (r = 0.97). This find-Open Journal of Pediatrics ing was also made by Djohan et al [26] in a study conducted in Côte d'Ivoire, where he noted a strong correlation between venous blood glucose (cord blood)…”

Section: Discussionmentioning

confidence: 47%

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Ouattara¹,

Cissé²,

Koffi³

et al. 2017

OJPed

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The purpose of this study is to determine the prevalence, the characteristics of hypoglycaemia in the newborn admitted to emergency departments of teaching Hospital of Treichville, Abidjan and to evaluate the relevance of capillary blood glucose in this diagnosis. Patients and Methods: This prospective cross-sectional study was held from 01 February to 25 June 2017 in the Pediatric Emergency Department. It involved 201 newborns under 24 hours of age who consulted in pediatric emergency for any reason. Data were collected from parent direct interviews, analysis of the follow-up record, physical examination of the newborn, results of glucose level in the capillary blood at heel and in venous blood. On dry tube and gray tube (containing sodium fluoride and potassium oxalate), the blood glucose on the latter tube constituting the reference blood glucose, with neonatal hypoglycaemia defined by a venous blood glucose less than or equal to 2.5 mmol/l (0.45 g/l). The statistical tests used were the frequency comparison, the Chi Square, the Fisher Test with a significance threshold p < 0.05 or the Odds-ratio with a confidence interval of 95% and a significance threshold of 5%, but also with the correlation coefficient. Results: Newborns of less than 3 hours of life (70.6%) were the most represented with a male predominance (sex ratio = 2.9). The reasons for consultation were dominated by neurological disorders (36.5%), prematurity (31.8%), and fever (22.2%). The average time to complete the blood glucose test was less than one hour after the sampling in 6.5% of the cases. The mean blood glucose was 0.59 g/l (3.28 mmol/l) with extremes ranging from 0.15 to 1.8 g/l (0.83 mmol/l to 10 mmol/l). The prevalence of hypoglycemia by the instantaneous glycemic method was 15.9%. On tube containing sodium fluoride and potassium oxalate, it was 20.4%, while the prevalence of red blood cell hypoglycemia was 38.1%. A good correlation was found between capillary glycemia and gray tube with r = 0.97. Signs associated with hypoglycemia were predominantly male (p < 0.05), prematurity (p < 0.05). As for cerebral suffering, it had proved to be a protective factor (Fisher: 0.002). The mortality rate was 2.5%. Hypoglycemia was not found. Conclusion: Hypoglycaemia is relatively common in our working setting, particularly in premature infants. However, it should be carefully sought in any newborn admitted to emergency regardless of the reason for admission. The use of capillary blood glucose proves to be a good alternative because it allows a fast management.

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Section: Discussionmentioning

confidence: 47%

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Ouattara¹,

Cissé²,

Koffi³

et al. 2017

OJPed

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“…The number of subjects in the previous studies widely exceed the number in the present study, and the present study does not exclude the possibility of the occurrence of hypoglycemia among healthy subjects. However, there are many problems associated with blood glucose analyses that may cause false low blood glucose measurements (Elimam et al, 1997;Marcus, 2001) and to the best of our knowledge, no studies have shown that clinically relevant hypoglycemia, as defined by Whipple, occurs among otherwise healthy individuals. The present study, although based on a small number of patients, confirms that symptoms attributed to hypoglycemia are unlikely to represent true hypoglycemia in healthy adults.…”

Section: Discussionmentioning

confidence: 99%

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

2007

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Background and Objectives: Among otherwise healthy adults, there is a subgroup of individuals who develop symptoms of hypoglycemia during episodes of food restriction. The aim of the present study was to investigate whether such individuals develop hypoglycemia or react abnormally in other metabolic aspects during a 24-hour fast. Subjects and Methods: Ninety medical students were asked if they wanted to participate. Sixteen were selected; none dropped out. A 24-hour fast was performed at a hospital ward. Blood samples and questionnaires were taken at eight specific times. Result: During the fast, the sensitive group reported significantly higher scores on 'irritation' and 'shakiness'. However, no hypoglycemia occurred and the lowest detected blood glucose concentration was 3.7 mmol/l. There were no differences between the groups in plasma glucose, cortisol, growth hormone (GH), insulin, b-hydroxybutyrate (b-OH) and lactate levels. The blood pressures and heart rates were also similar. Conclusions: Adults, despite subjective signs of hypoglycemia, can fast without any metabolic or endocrine derangement.

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“…Traditionally, blood glucose has been conveniently measured on capillary samples using chemical strips or portable, bedside glucose meters as a substitute for formal laboratory analysis. Unfortunately, many of these 'point-of-care' methods are not reliable at the low glucose levels (by adult comparison) found in healthy newborns, and are prone to sample or observer error (29,30) (Level 3b). In addition, variations between capillary and venous blood (31), blood and plasma, and immediate and stored samples may confound results (Level 3b); in particular, delays in processing may result in artefactually lower levels.…”

Section: How Should Screening For Neonatalmentioning

confidence: 99%

Screening guidelines for newborns at risk for low blood glucose

Aziz¹,

Dancey²

2004

Paediatrics &Amp; Child Health

103

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How to measure and interpret glucose in neonates

Cited by 7 publications

References 10 publications

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

Screening guidelines for newborns at risk for low blood glucose

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How to measure and interpret glucose in neonates

Cited by 7 publications

References 10 publications

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-C&#244;te d’Ivoire)

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-C&#244;te d’Ivoire)

Effect of fasting on young adults who have symptoms of hypoglycemia in the absence of frequent meals

Screening guidelines for newborns at risk for low blood glucose

Contact Info

Product

Resources

About

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)