Controversy persists about whether snoring can affect atherosclerotic changes in adjacent vessels, independent of obstructive sleep apnea and other cardiovascular risk factors. This study examined the independent association between snoring and carotid artery intima-media thickness (IMT) in nonapneic snorers and nonsnorers. We studied 180 nonapneic snorers and nonsnorers undergoing in a full-night home-based sleep study. Snoring sound was objectively measured by a microphone. Based on snoring time across the night, participants were classified as nonsnorers (snoring time: 0%), mild snorers (1–25%), and moderate to heavy snorers (≥ 25%). We measured IMT on both common carotid arteries. The three groups were matched by age, body-mass index, cholesterol, blood pressure, and glucose levels, using weights from generalized boosted-propensity score models. Mean carotid IMT increased with increased snoring time across the night in women: nonsnorers (0.707 mm), mild (0.718 mm), and moderate to heavy snorers (0.774 mm), but not in men. Snoring during at least one fourth of a night’s sleep is independently associated with subclinical changes in carotid IMT in women only.