While past research has focused on the benefits of social media during pandemics, this study emphasizes the possible negative effects of social media use among healthcare professionals. It has been stated that healthcare professionals are exposed to COVID-19 and its impacts on the mental health of these workers. Even though recognizing the importance of healthcare professionals during the pandemic, the impacts of COVID-19 on the mental health of healthcare professionals have been rarely considered for investigation by researchers. By applying differential susceptibility to the media effects model (DSMM), the current article investigated the effect of COVID-19 information overload (CIO) on psychological and mental well-being and underline mechanisms. Time-wave technique was applied to collect the data. This study tested moderated mediation model by collecting data from 314 healthcare professionals. The findings stated that COVID-19 information overload impacted COVID-19 fatalism and COVID-19 exhaustion directly. Likewise, COVID-19 fatalism mediated the association between CIO and COVID-19 exhaustion. Moreover, the COVID-19 stressor moderated this mediating relationship. This study proposes several practical recommendations for healthcare professionals, social media platform providers, health authorities, organizations, and institutions on how to use social media effectively and sustainably during the global COVID-19 epidemic.