How to use...  neonatal TORCH testing

Jong, Eveline P. de; Vossen, Ann C.T.M.; Walther, Frans J.; Lopriore, Enrico

doi:10.1136/archdischild-2012-303327

Cited by 55 publications

(64 citation statements)

References 115 publications

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“…The acronym "TORCH" was introduced by Nahmias in 1971 to highlight a group of pathogens that cause a congenital and perinatal infections leading to fetal and neonatal morbidity and mortality: Toxoplasma gondi, rubella virus, Cytomegalovirus (CMV) and herpes simplex virus 1,2 . These pathogens usually cause only asymptomatic or mild infections in mother, but can cause much more serious consequences in fetus 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Congenital malformations have a direct impact on the family and place a financial burden on medical, educational and support services 4 . This acronym was proposed to simplify diagnostic procedures in severely ill children and to impose clearer structure in the large differential diagnosis of congenital infections 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Most children develop normally, but about 20% develop sequale. Congenital toxoplasmosis may result in retinochoroiditis and retinal scarring in 12% of children and neurological abnormalities in about 12%-16% cases 1 . Large variation in seroprevalence may exit due to differences in climate; cultural differences in amount of raw meat consumed, and increased consumption of meat from animals firmed outdoors and frozen meat 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Although HSV can be vertically transmitted during pregnancy, this is extremely rare. Neonatal disease is the result of perinatal transmission 1 . Of all the children born with neonatal HSV infection, 60% -80% of mothers are asymptomatic for the disease.…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of TORCH Infections in Children

Biswas

Badruddoza

Sultana

2018

Chatt Maa Shi Hosp Med Coll J

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Background : The acronym “TORCH” was introduced to highlight a group of pathogens that cause a congenital and perinatal infections: Toxoplasma gondi, rubella virus, Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV). These pathogens are often associated with congenital anomalies. Congenital malformations have a direct impact on the family. This study was undertaken to detect the serological evidence of TORCH infections in children, by establishing the presence of specific IgM antibodies. Methods: During the period 1st June 2016 to 30th May 2017, 58 suspected TORCH infection cases were included from Paediatrics Department of CMOSH for TORCH antibody detection. The children were in the age of 0 day to 1 year with an average age of 3.3±2.59 months. The serum samples were tested forIgM and IgG antibodies against TORCH agents by using enzyme linked immunoassay method (ELISA). Results: Among the 58 children, seropositivity was found in 55 (94.82%) cases. Of the 55 seropositive cases serological evidence for combination of IgM and IgG with any one of the TORCH agents was detected in 25 (43.10%) and IgG alone was detected in 30 (51.72%) children. IgM/IgG antibody positivity to Toxoplasma, Rubella, CMV and HSV was 21(36.21%), 50(86.21%), 52(89.66%) and 8(13.79%) respectively. IgM anti-CMV were observed in highest number of cases 19(32.76%), followed by IgM anti-rubella 7(12.07%). IgM against HSV and Toxoplasma were found in equal number of cases, 3(5.17%) each. Conclusions: Awareness amongst clinicians and mothers about TORCH infections and their consequences should be developed. Chatt Maa Shi Hosp Med Coll J; Vol.17 (1); Jan 2018; Page 13-16

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Seroprevalence of TORCH Infections in Children

Biswas

Badruddoza

Sultana

2018

Chatt Maa Shi Hosp Med Coll J

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“…Although multiple previous studies have questioned the utility of TORCH testing in the SGA population, the findings are interpreted only in the epidemiological context of congenital infections [1,5,6]. The majority of the studies recommend TORCH serology testing only in the setting of symptomatic infants [7]. However, some still recommend cytomegalovirus (CMV) screening in asymptomatic SGA infants given the outcomes of sensorineural hearing loss [4].…”

Section: Introductionmentioning

confidence: 99%

The C in TORCH: A Cost-Effective Alternative to Screening Small-for-Gestational-Age Infants

2014

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Background: Infants born with birth weights under the 10th percentile for their gestational age are classified as small for gestational age (SGA). TORCH infections are reported to be associated with SGA infants. With the low incidence of infections, screening is likely to be expensive and of low utility. Objective: The objective of this study was to determine the utility and cost-effectiveness of screening SGA infants with TORCH serology titers, urine cytomegalovirus (CMV) cultures and cranial ultrasounds. Methods: A retrospective review was conducted on all infants admitted to the neonatal intensive care unit (NICU) at Los Angeles County and University of Southern California (LAC+USC) Medical Center from January 2003 to December 2011 with a diagnosis of SGA or intrauterine growth restriction. Birth characteristics such as birth weight, length, head circumference and gestational age were recorded. TORCH titer results, urine CMV results and cranial ultrasound findings were collected. Results: Between 2003 and 2011, 232 SGA infants were admitted to the NICU at LAC+USC Medical Center. Of these, 117 infants (50%) had TORCH titer testing performed; there was only 1 positive CMV IgM and 1 positive HSV IgM result. Repeat urine CMV testing was performed on 109 infants (47%), with a total of 296 urine CMV samples collected from these infants; 6 infants had positive results, of whom 3 had repeat positive urine CMV samples. Overall, 149 of the infants had a cranial ultrasound done, none of which were positive for calcifications. Conclusions: TORCH titer testing, urine CMV screening and cranial ultrasound screening are of low yield in screening clinically asymptomatic SGA infants for TORCH infections. Given the low number of positive results, a cost-effective alternative of selective TORCH testing may be limited to infants with additional clinical findings. This study serves as a reminder to periodically examine testing practices and patient population to maximize cost-effectiveness.

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Viral Infections

Sterling

2016

Rook's Textbook of Dermatology, Ninth Edition

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How to use... neonatal TORCH testing

Cited by 55 publications

References 115 publications

Seroprevalence of TORCH Infections in Children

Seroprevalence of TORCH Infections in Children

The C in TORCH: A Cost-Effective Alternative to Screening Small-for-Gestational-Age Infants

Viral Infections

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