How Uncommon are Isolated Lung Metastases in Colorectal Cancer? A Review from Database of 754 Patients Over 4 Years

Tan, Ker Kan; Lopes, Gilberto; Sim, Richard

doi:10.1007/s11605-008-0757-7

Cited by 126 publications

(92 citation statements)

References 32 publications

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“…This supports the contention that haematogenous spread via the iliac veins results in a higher incidence of lung metastases from rectal cancer. 13,14 By contrast, locoregional recurrence of rectal tumors was relatively uncommon and certainly no more frequent than colonic tumors. This is consistent with the modern use of surgical techniques to ensure a complete excision of the mesorectum selectively combined with the use of chemoradiotherapy that has dramatically reduced the rates of locoregional recurrence from rectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

et al. 2016

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Running head: Analysis of recurrence in the FACS study Mini AbstractRecurrence is a frequent cause of mortality following treatment for colorectal cancer with curative intent. This retrospective cohort analysis examines patterns of recurrence, and factors determining post-recurrence survival, in a large cohort of accurately staged patients treated curatively for DukesÕ A-C primary colorectal cancer from the FACS randomised controlled trial. 1 Structured Abstract ObjectiveTo describe patterns of recurrence and post-recurrence survival (PRS) in a large cohort of accurately staged patients with DukesÕ A-C colorectal cancer (CRC). BackgroundRecurrence remains a frequent cause of mortality following the treatment of CRC with curative intent. Understanding the likelihood and site of recurrence informs adjuvant treatment and follow-up. MethodsRetrospective cohort analysis of data from the FACS (Follow-up after Colorectal Cancer Surgery) trial after a median 4.4 years follow-up; PRS was calculated using the Kaplan-Meier method. ResultsComplete data were available for 94% of patients; 189 (17%) had experienced recurrence.

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Section: Discussionmentioning

confidence: 99%

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

et al. 2016

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“…Metastases are present at the time of diagnosis in up to 30% of patients with colorectal cancer (1). Hematogenous spread is known to be one of the principal mechanisms of systemic metastasis in colorectal malignancy.…”

Section: Introductionmentioning

confidence: 99%

“…Hematogenous spread is known to be one of the principal mechanisms of systemic metastasis in colorectal malignancy. The most common metastatic site is the liver, with an overall prevalence of approximately 40-50% over the course of the disease (2), while the second most common site is the lungs, with a prevalence of approximately 10-15% (1,3). However, the likelihood of cancer spreading to a particular site might be influenced by the location of the tumor within the colorectum.…”

Section: Introductionmentioning

confidence: 99%

Location of rectal cancer as determined using rectal magnetic resonance imaging, and its relationship with pulmonary metastasis

Han¹,

Kim²,

Park³

et al. 2015

Turk J Gastroenterol

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Background/Aims: The aim of this study was to evaluate the accuracy of 3-T magnetic resonance imaging (MRI) in locating rectal cancer, and to determine whether tumor location correlates with the incidence of pulmonary metastasis. Materials and Methods: A total of 146 patients with confirmed rectal adenocarcinoma underwent 3-T rectal MRI, and abdominal and chest computed tomography (CT) within 2 weeks of the endoscopic examination. We reviewed the distance between the mass and the anal verge recorded in the endoscopic reports of these patients. Two radiologists evaluated the same distance on MRI scans by using picture archiving and communications systems. Multiple factors including the tumor location, primary tumor and lymph node stage, lung and liver metastasis, pathologic differentiation, and the carcinoembryonic antigen level were evaluated. The correlation between tumor location on MRI and endoscopy was assessed, and significant factors influencing pulmonary metastasis were identified using multivariate logistic regression analysis. Results: There was a statistically significant correlation between the tumor location established using MRI and the actual location recorded during endoscopy. The incidence of pulmonary metastasis was significantly higher in patients with lower rectal cancer (11/17, 65%) compared to those with upper rectal cancer (6/17, 35%; p<0.05). Factors associated with pulmonary metastasis were tumor location and the presence of liver metastasis. Conclusion: The accurate tumor location could be indicated using 3-T rectal MRI. Pulmonary metastasis occurred more frequently in patients with lower rectal cancer than in those with upper rectal cancer.

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“…Frequency was nearly three times higher for patients with rectal cancer than for patients with colon cancer. Smaller studies [42][43][44] have shown isolated lung metastases in 9-18% of patients with rectal cancer; although distant metastases can be identified in other organs including the bone and the brain [38].…”

Section: Introductionmentioning

confidence: 99%

High-Risk Human Papillomavirus and Colorectal Carcinogenesis

Moustafa¹,

Al-Antary²,

Yasmeen³

2016

Human Papillomavirus - Research in a Global Perspective

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Colorectal, colon and rectal, cancer is the third most common malignancy in both men and women worldwide. Colorectal carcinogenesis is a complex, multistep process implicating environmental and lifestyle factors in addition to gene mutation and viral infections. On the other hand, it is well established that human papillomaviruses (HPVs) infection play a crucial role in certain types of human carcinomas including cervical and head and neck (HN); as roughly 96% and 30% of these cancers are positive for high-risk HPVs, respectively. Moreover, it has been reported that the presence of high-risk HPVs is associated with vascular invasion, lymph node metastases, and tumor size in cervical and HN cancers. Recently, several investigations pointed-out that high-risk HPVs are present in around 70% of human colorectal cancers. Likewise, our group has demonstrated that E6/E7 oncoproteins of HPV type 16 convert noninvasive and nonmetastatic human cancer cells to invasive and metastatic form. Accordingly, it is evident that high-risk HPVs are present in human colorectal cancers where they could play an important role in the development of these malignancies. In this chapter, we will discuss the presence and role of high-risk HPVs in human colorectal carcinogenesis and metastasis; particularly, the interaction between E5 and E6/E7 oncoproteins of high-risk HPVs in colorectal malignancies, which has been linked with the initiation and progression of these tumors.

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How Uncommon are Isolated Lung Metastases in Colorectal Cancer? A Review from Database of 754 Patients Over 4 Years

Cited by 126 publications

References 32 publications

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

Site and Stage of Colorectal Cancer Influence the Likelihood and Distribution of Disease Recurrence and Postrecurrence Survival

Location of rectal cancer as determined using rectal magnetic resonance imaging, and its relationship with pulmonary metastasis

High-Risk Human Papillomavirus and Colorectal Carcinogenesis

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