How useful is SBF in predicting in vivo bone bioactivity?

Kokubo, Tadashi; Takadama, Hiroaki

doi:10.1016/j.biomaterials.2006.01.017

Cited by 8,088 publications

(5,204 citation statements)

References 46 publications

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“…28 The samples were incubated in SBF solution for 1, 3, 7, and 14 days at 378C. The filtrate was analyzed by inductively coupled plasma mass spectrometry (ICP-MS, Perkin Elmer model DRC II) at each time point to determine the amount of released Ca 21 , P 51 , Se 61 , and Fe 31 ions.…”

Section: In Vitro Bioactivity Testmentioning

confidence: 99%

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

et al. 2017

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Dual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe 31 )/selenate (SeO 22 4 ) ions into the HA structure (Ca 10-x-y Fe y (PO 4 ) 6-x (SeO 4 ) x (OH) 2-x-y O y ) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM). XRD and FTIR analyses revealed that Fe-SeHA samples were phase pure at 9008C. FESEM images showed that formation of rod-like shaped particles was inhibited dramatically with increasing Fe 31 amount. The Vickers hardness (HV) test showed that hardness values increased with increasing Fe 31 concentrations. Optical spectra of Fe-SeHA materials contained broadband over (200-600) nm. In vitro degradation and bioactivity tests were conducted in simulated body fluid (SBF). The incorporation of Fe 31 /SeO 22 4 ions into the HA structure resulted in a remarkably higher degradation rate along with intense growth of apatite granules on the surface of the Fe-SeHA discs with Ca/P ratio of 1.35-1.47. In vitro protein adsorption assay was conducted in fetal bovine serum (FBS) and it was observed that the adsorption of serum proteins on Fe-SeHA samples significantly increased with increasing Fe 31 concentration. In vitro cytotoxicity tests were performed with human fetal osteoblast (hFOB)

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Section: In Vitro Bioactivity Testmentioning

confidence: 99%

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

et al. 2017

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“…In vitro bioactivity tests were carried out on TT-CEL2, TT-FaGC, and TT-SCNA small disks (diameter 10 mm, height 5 mm) by soaking the samples for seven days in 30 mL of simulated body fluid (SBF) prepared according to the Kokubo's protocol [33]. The specimens were maintained at 37 • C in sealed polyethylene bottles and the solution was refreshed twice a week.…”

Section: In Vitro Bioactivitymentioning

confidence: 99%

Production and Characterization of Glass-Ceramic Materials for Potential Use in Dental Applications: Thermal and Mechanical Properties, Microstructure, and In Vitro Bioactivity

Baino

Verné

2017

Applied Sciences

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Abstract:Multicomponent silicate glasses and their corresponding glass-ceramic derivatives were prepared and tested for potential applications in dentistry. The glasses were produced via a melting-quenching process, ground and sieved to obtain fine-grained powders that were pressed in the form of small cylinders and thermally treated to obtain sintered glass-ceramic samples. X-ray diffraction investigations were carried out on the materials before and after sintering to detect the presence of crystalline phases. Thermal analyses, mechanical characterizations (assessment of bending strength, Young's modulus, Vickers hardness, fracture toughness), and in vitro bioactivity tests in simulated body fluid were performed. On the basis of the acquired results, different potential applications in the dental field were discussed for the proposed glass-ceramics. The use of such materials can be suggested for either restorative dentistry or dental implantology, mainly depending on their peculiar bioactive and mechanical properties. At the end of the work, the feasibility of a novel full-ceramic bilayered implant was explored and discussed. This implant, comprising a highly bioactive layer expected to promote osteointegration and another one mimicking the features of tooth enamel, can have an interesting potential for whole tooth substitution.

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“…The standard SBF solution was prepared according to Kokubo's protocol. 40 For this purpose, initial materials including NaCl, NaHCO3, KCl, K2HPO4·3H2O, MgCl2·6H2O, CaCl2, Tris-buffer, and 1 N HCl were used. The SBF solution was prepared by dissolving reagent-grade NaCl, KCl, NaHCO3, MgCl2·6H2O, CaCl2 and KH2PO4 into distilled water and buffering it at pH = 7.25 with Tris-buffer and HCl 1 N at 37 °C.…”

Section: In Vitro Bioactivitymentioning

confidence: 99%

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Yazdimamaghani

Razavi

Vashaee

et al. 2015

Materials Science and Engineering: C

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A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dipcoating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds.

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How useful is SBF in predicting in vivo bone bioactivity?

Cited by 8,088 publications

References 46 publications

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

Production and Characterization of Glass-Ceramic Materials for Potential Use in Dental Applications: Thermal and Mechanical Properties, Microstructure, and In Vitro Bioactivity

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

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How useful is SBF in predicting in vivo bone bioactivity?

Cited by 8,088 publications

References 46 publications

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

Fe3+/− dual doped nano hydroxyapatite: A novel material for biomedical applications

Production and Characterization of Glass-Ceramic Materials for Potential Use in Dental Applications: Thermal and Mechanical Properties, Microstructure, and In Vitro Bioactivity

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

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Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications

Fe³⁺/⁻ dual doped nano hydroxyapatite: A novel material for biomedical applications