2014
DOI: 10.18632/oncotarget.1841
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HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression

Abstract: Cell-cell adhesion molecule cadherin-11(CDH11) is preferentially expressed in basal-like breast cancer cells and facilitates breast cancer cell migration by promoting small GTPase Rac activity. However, how the expression of CDH11 is regulated in breast cancer cells is not understood. Here, we show that CDH11 is transcriptionally controlled by homeobox C8 (HOXC8) in human breast cancer cells. HOXC8 serves as a CDH11-specific transcription factor and binds to the site of nucleotides −196 to −191 in the CDH11 pr… Show more

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Cited by 34 publications
(42 citation statements)
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“…Moreover, the analysis of publically available human breast tumor microarray gene expression database demonstrates a strong positive linear association between HOXC8 and CDH11 expression (R = 0.801, p < 0.001). Survival analysis (Kaplan-Meier method, log-rank test) show that both high HOXC8 and CDH11 expression correlates with poor recurrence-free survival rate of patients (Li et al, 2014). Together, these findings suggest that HOXC8 promotes breast tumorigenesis by maintaining high level of CDH11 expression in breast cancer cells.…”
Section: Breast Cancermentioning
confidence: 82%
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“…Moreover, the analysis of publically available human breast tumor microarray gene expression database demonstrates a strong positive linear association between HOXC8 and CDH11 expression (R = 0.801, p < 0.001). Survival analysis (Kaplan-Meier method, log-rank test) show that both high HOXC8 and CDH11 expression correlates with poor recurrence-free survival rate of patients (Li et al, 2014). Together, these findings suggest that HOXC8 promotes breast tumorigenesis by maintaining high level of CDH11 expression in breast cancer cells.…”
Section: Breast Cancermentioning
confidence: 82%
“…Ectopic HOXC8 expression induces Cdh11 expression and promotes breast tumorigenesis (Li et al, 2012). Importantly, forced Cdh11 expression reverses the inhibitory effect in breast tumorigenesis elicited by HOXC8 knockdown (Li et al, 2014). Moreover, the analysis of publically available human breast tumor microarray gene expression database demonstrates a strong positive linear association between HOXC8 and CDH11 expression (R = 0.801, p < 0.001).…”
Section: Breast Cancermentioning
confidence: 93%
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“…This event is part of a process that is vital to malignant change, the epithelial-mesenchymal transition (EMT). EMT is a key biologic process that was initially identified as a developmental program that enables polarized epithelial cells to acquire a motile mesenchymal phenotype (1317,19,20). This transition results in a more invasive and metastatic phenotype (1517,19).…”
Section: Introductionmentioning
confidence: 99%