HPLC based activity profiling for 5-lipoxygenase inhibitory activity in Isatis tinctoria leaf extracts

Oberthür, Christine; Jäggi, R.; Hamburger, Matthias

doi:10.1016/j.fitote.2005.03.002

Cited by 39 publications

(33 citation statements)

References 11 publications

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“…The treatment did not cause a significant difference in tissue levels of COX-1 and COX-2, immunohistochemically determined. These results appear to disagree with those reported by Orberthür et al [29] where a preferential inhibition of COX-2 and a reduced expression of iNOS was observed. In vitro studies demonstrated that the DCM extract is able to inhibit both tumour necrosis factor-α (TNF-α) and IL-β production in RAW 264,7 macrophages [64].…”

Section: Biological Activitiescontrasting

confidence: 99%

“…Due to the huge cultivation in Europe for the production of indigo dye, from the 12th century until the 17th century, I. tinctoria was also extensively used as a medicinal plant to treat snake bites, wounds, and other inflammatory ailments [6,29]. These medicinal properties have been widely described in a number of Renaissance and Baroque herbal texts, which recommended woad for treating haemorrhoids, ulcers, and tumours [6].…”

Section: Ethnobotanical Usesmentioning

confidence: 99%

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Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Speranza

Miceli

Taviano

et al. 2020

Plants

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Isatis tinctoria L. (Brassicaceae), which is commonly known as woad, is a species with an ancient and well-documented history as an indigo dye and medicinal plant. Currently, I. tinctoria is utilized more often as medicinal remedy and also as a cosmetic ingredient. In 2011, I. tinctoria root was accepted in the official European phytotherapy by introducing its monograph in the European Pharmacopoeia. The biological properties of raw material have been known from Traditional Chinese Medicine (TCM). Over recent decades, I. tinctoria has been investigated both from a phytochemical and a biological point of view. The modern in vitro and in vivo scientific studies proved anti-inflammatory, anti-tumour, antimicrobial, antiviral, analgesic, and antioxidant activities. The phytochemical composition of I. tinctoria has been thoroughly investigated and the plant was proven to contain many valuable biologically active compounds, including several alkaloids, among which tryptanthrin, indirubin, indolinone, phenolic compounds, and polysaccharides as well as glucosinolates, carotenoids, volatile constituents, and fatty acids. This article provides a general botanical and ethnobotanical overview that summarizes the up-to-date knowledge on the phytochemistry and biological properties of this valuable plant in order to support its therapeutic potential. Moreover, the biotechnological studies on I. tinctoria, which mainly focused on hairy root cultures for the enhanced production of flavonoids and alkaloids as well as on the establishment of shoot cultures and micropropagation protocols, were reviewed. They provide input for future research prospects.

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Section: Biological Activitiescontrasting

confidence: 99%

Section: Ethnobotanical Usesmentioning

confidence: 99%

Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Speranza

Miceli

Taviano

et al. 2020

Plants

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“…tinctoria is also a medicinal plant with antiinflammatory and anti-tumoral properties due to indole-derived compounds (principally glucosinolate) located in the leaves (Galletti et al 2006;Oberthür et al 2005;Hamburger 2002), roots (Chen et al 2002) and seeds (Fréchad et al 2001). The essential oils contained in the seeds are also used to produce cosmetics such as soap and body creams due to their emollient and moisturising properties.…”

Section: Introductionmentioning

confidence: 99%

Adaptability and variation in Isatis tinctoria L.: a new crop for Europe

Spataro

Negri

2007

Euphytica

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Isatis tinctoria L. was cultivated until the 19th century to produce indigo, a natural blue pigment used principally for dyestuffs. The current search for alternative crops and interest in natural products has led to reconsidering I. tinctoria as a crop to be grown in marginal areas to produce natural indigo. To reintroduce I. tinctoria into cultivation, its behaviour under different climatic conditions as well as its morpho-physiological and genetic diversity must be assessed in order to evaluate the possibilities of future breeding work. To do this, a Eurasian collection of 15 accessions was studied in a 2-year experiment. The study was carried out in four locations in order to assess plant performance at altitudes ranging from 380 to 1,700 m a.s.l. A second experiment evaluated the morpho-physiological diversity of several traits (some related to agronomic performances) of the collection. In a third experiment the genetic traits of the collection were characterised by using eight AFLP and eight SAMPL markers. The species showed a wide adaptability to different mountainous conditions and the populations showed high morphologic and genetic variability and differed according to their origins. Both morpho-physiological and molecular characterisation allowed the accessions to be distinguished into groups of European and Asian origin. Future breeding work is recommended because some accessions have good agronomic potential.

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“…Tryptanthrin and its derivatives display a wide array of intriguing pharmacological activities such as antimicrobial [59,66,72,[75][76][77][78][79], antiprotozoal [56,80], antiparasitic [81], anti-inflammatory [65,[82][83][84][85], and antioxidant [86]. Its efficacy against allergy [87], intestinal disorders [88], and inflammatory bowel disease [89] has also been reported.…”

Section: Medicinal Valuementioning

confidence: 99%