Quercetin and Tryptanthrin

Shankar, G Mohan; Antony, Jayesh; Anto, Ruby John

doi:10.1016/bs.enz.2015.05.001

Cited by 24 publications

(4 citation statements)

References 95 publications

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“…Plants are exposed to some damages from the surrounding environment, such as UV-radiation and microbial infection, so the process of flavonoids biosynthesis is considered the first line of defense against these external damages [18]. Flavonoids can be biosynthesized via the phenylpropanoid metabolic pathway.…”

Section: Biosynthesis and Natural Sourcesmentioning

confidence: 99%

“…Quercetin is the most abundant flavonoid, found in fruits, vegetables, and grains. The compound is widely found in many plant species such as apples, honey, raspberries, onions, red grapes, radish, cherries, pears, tomatoes, coriander, green tea, red lettuce, fennel, green beans, asparagus, green pepper, sweet potato, citrus, and dill (Figure 3) [18,21,22]. As a result of the diversity of the environmental conditions and Ayurvedic culture, the sources of quercetin also vary in different regions around the world [22].…”

Section: Biosynthesis and Natural Sourcesmentioning

confidence: 99%

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Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

A. Ghareeb,

Z. Zayan,

H. Shari

et al. 2024

Quercetin - Effects on Human Health [Working Title]

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Quercetin, a naturally occurring flavonoid, has gained significant attention in recent years due to its potential health benefits and versatile applications. This book chapter explores the chemistry of quercetin, shedding light on its molecular structure, biosynthesis, and extraction methods. The chapter delves into the extensive research on the health effects of quercetin, highlighting its antioxidant, anti-inflammatory, anticancer, neuroprotective, and cardioprotective properties. Moreover, the potential risks and toxicity associated with quercetin consumption are thoroughly examined, emphasizing the importance of proper dosage and potential drug interactions. The chapter concludes by providing an overview of recent advances in quercetin development, including nanoformulations, targeted delivery systems, and combination therapies, that hold promise for enhancing its therapeutic efficacy and bioavailability. This comprehensive exploration of quercetin aims to provide researchers, scientists, and healthcare professionals with valuable insights into its multifaceted nature and potential applications in human health.

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Section: Biosynthesis and Natural Sourcesmentioning

confidence: 99%

Section: Biosynthesis and Natural Sourcesmentioning

confidence: 99%

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

A. Ghareeb,

Z. Zayan,

H. Shari

et al. 2024

Quercetin - Effects on Human Health [Working Title]

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show abstract

“…With their functional versatility, extremely common occurrence in nature, and involvement in large numbers of biological pathways, will the increased investment in heterocyclic‐based anticancer drug design continue to justify their place in the race to combatting one of the world's most devastating diseases? Many marketed heterocyclic drugs are available or in various clinical trials viz ., doxorubicin 1, cisplatin 2, methotrexate 3, fluorouracil 4, , quercetin 5 , tryptanthrin 6, and napabucasin 7 that showed the anticancer activity (Figure ). This review summarizes and provides updated literature on heterocyclic compounds using various cancer cell lines reported during the period of 2014–2017 together with the structure‐activity relationships.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines

Tandon

Singh

Luxami

et al. 2018

The Chemical Record

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Besides worthy development in cancer therapy, cancer is still one of the leading causes of death, worldwide. The future burden of cancer will probably be even larger because people are adopting poor lifestyles with poor diet, frequently smoking and less physical activity. The effective anticancer drugs having efficacy and selectivity with low toxicity is still a challenge for the scientific fraternity. The advances in the cancer study have its origin on the availability of different types of experimental model systems that review the various forms of this disease. Cell lines emerge as a feasible alternative for anticancer activities, being at the same time easy to manipulate and molecularly characterize. Heterocycles are key structural components of many of the anti-cancer drugs available on the market today. Indeed, of the novel molecular anti-cancer agents approved by the FDA between 2010 and 2017, almost two-thirds contained heterocyclic rings within their structures. This review summarizes and provides updated literature on heterocyclic compounds using various cancer cell lines reported during the period of 2014-2017 together with the structure-activity relationships.

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“…Our previous studies and others have shown that quercetin is the major flavonoid of T. sinensis leaves [22, 23]. Pharmacological investigations have demonstrated that quercetin has diverse biological effects such as antioxidant [24], anticancer [25], anti-inflammatory [26], and cardioprotective activities [27, 28]. Quercetin also plays a crucial role in aldose reductase inhibition [29, 30].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-Carbohydrate/High-Fat Diet and Alloxan Induced Experimental Diabetic Mice

Zhang

Dong

Wang

et al. 2016

Journal of Diabetes Research

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The development of diabetes mellitus is related to oxidant stress induced by a high carbohydrate/high-fat diet (HFD). Quercetin, as a major bioactive component in Toona sinensis leaves (QTL), is a natural antioxidant. However, the exact mechanism by which QTL ameliorate diabetes mellitus is still unknown. In this study, we investigated the hypoglycemic effects and hepatocytes protection of QTL on HFD and alloxan induced diabetic mice. Intragastric administration of QTL significantly reduced body weight gain, serum glucose, insulin, total cholesterol, triglyceride, low density lipoprotein-cholesterol, alanine aminotransferase, and aspartate aminotransferase serum levels compared to those of diabetic mice. Furthermore, it significantly attenuated oxidative stress, as determined by lipid peroxidation, nitric oxide content, and inducible nitric oxide synthase activity and as a result attenuated liver injury. QTL also significantly suppressed the diabetes-induced activation of the p65/NF-κB and ERK1/2/MAPK pathways, as well as caspase-9 and caspase-3 levels in liver tissues of diabetic mice. Finally, micrograph analysis of liver samples showed decreased cellular organelle injury in hepatocytes of QTL treated mice. Taken together, QTL can be viewed as a promising dietary agent that can be used to reduce the risk of diabetes mellitus and its secondary complications by ameliorating oxidative stress in the liver.

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Quercetin and Tryptanthrin

Cited by 24 publications

References 95 publications

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

Unveiling the Potential of Quercetin: Chemistry, Health Benefits, Toxicity, and Cutting-Edge Advances

Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines

Quercetin Isolated from Toona sinensis Leaves Attenuates Hyperglycemia and Protects Hepatocytes in High-Carbohydrate/High-Fat Diet and Alloxan Induced Experimental Diabetic Mice

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