HPLC Determination of Dacarbazine, Doxorubicin, and Ondansetron Mixture in 5% Dextrose Injection on Underivatized Silica with an Aqueous-Organic Mobile Phase

Simultaneous Determination of Dexamethasone, Ondansetron, Granisetron, Tropisetron, and Azasetron in Infusion Samples by HPLC with DAD Detection

“…On the basis of the literature consulted [11–31], an acidic aqueous medium and acetonitrile were selected to start the optimization of mobile phase composition. Trials showed that an acidic mobile phase with reverse phase C 18 column gives symmetric and sharp peaks.…”

“…From the literature survey it is evident that various analytical methods were available for the determination of DEX, OND, GRA, TRO, and AZA with other combinations by using high-performance liquid chromatography (HPLC) [11–31]. No method has been reported in the literature for simultaneous estimation of DEX, OND, GRA, TRO, and AZA in infusion samples.…”

Some Tautomers of Dacarbazine - A DFT Study

“…There exist innumerous articles in the literature about the clinical applications of dacarbazine. Also there are various publications on the different aspects of dacarbazine properties [7][8][9][10][11][12]. When exposed to high temperatures (250-255 °C) dacarbazine decomposes explosively.…”

Validated spectral manipulations for determination of an anti-neoplastic drug and its related impurities including its hazardous degradation product

“… 5 According to the literature survey, DTIC was determined by HPLC methods either alone 6 or with other drugs. 7,8 HPLC methods were also used for determination of the ternary mixture but one of them required a very long time for analysis exceeding 25 minutes, 9 and the other one was gradient elution using acetonitrile 10 which is considered one of the most hazardous solvents to human health and environmental safety according to the environment, health and safety (EHS) and the life cycle assessment (LCA) protocols. 11 Chromatographic methods like HPLC also have various limitations like complexity, utilizing various expensive solvents, in addition to tedious sample pretreatment steps.…”