HPV 16 infection in a patient with two primary squamous cell carcinomas: of the uterine cervix and the anal mucosa

Abstract

Berner, Aa., Franzen, S. & Holm, R. HPV 16 infection in a patient with two primary squamous cell carcinomas: of the uterine cervix and the anal mucosa. APMIS 10.5: 207-212, 1997.A 43-year-old woman presented with metrorrhagia and a polypoid anal tumor. Cervical dilatation and endocervical curettage and resection of the anal tumor revealed two primary squamous cell carcinomas: of the uterine cervix and the anal mucosa. HPV 16 was identified in both tumors using an in situ hybridization technique with probes against HPV 6, 11, 16, 18, 31 and 33. The cervical carcinoma was weakly positive for p53 protein, whereas the anal tumor was p53 protein negative. Five years later a recurrence of the cervical carcinoma was diagnosed and a hysterectomy was performed. Of 3,013 patients with squamous cell carcinoma of either the cervix or the anus registered in our files, only one had a primary carcinoma in both locations. It was concluded hat HPV 16-induced squamous cell carcinoma may occur simultaneously in the cervix and the anus, and carcinoma in either of the two locations has to be ruled out when dealing with HPV infection in the anogenital tract.

The Association of High Risk Human Papillomaviruses in Patients With Cervical Cancer: An Evidence Based Study on Patients With Squamous Cell Dysplasia or Carcinoma for Evaluation of 23 Human Papilloma Virus Genotypes

“…Human papilloma viruses (HPVs) are the most important risk factor of cervical cancers, which is the second most prevalent cancer in females ( 1 ). The prevalence of invasive cervix cancer is low in some areas and its low incidence could be attributed to Pap smear screening test and HPV DNA test ( 2 ). Human papilloma viruses belong to the large and diverse Papillomaviradea family with more than 200 different subtypes, although only 15 types (including 16, 18, 31, 33, 35, 39, 45, 51,52, 56, 58,59, 68, 73 and 82) have been suggested as oncogenes ( 3 ).…”