HPV DNA and survivin expression in epithelial oral carcinogenesis: a relationship?

Human papillomavirus in oral squamous cells carcinoma in a population of 75 Brazilian patients

“…In most cases (14/18, 77.8%), only HPV-18 alone was detected; in 3 cases (16.7%), both HPV-18 and HPV-16 were identified; and in 1 case, only HPV-16 was detected. The present results agree with those reported by Shima et al [9], Giovannelli et al [10], and Lo Muzio et al [11], who detected HPV-18 in most of their samples at frequencies of 54%, 87.5%, and 87%, respectively. However, HPV-16 was the most frequent type in other studies [11][12][13].…”

“…The present results agree with those reported by Shima et al [9], Giovannelli et al [10], and Lo Muzio et al [11], who detected HPV-18 in most of their samples at frequencies of 54%, 87.5%, and 87%, respectively. However, HPV-16 was the most frequent type in other studies [11][12][13]. These divergent results suggest that the higher prevalence of HPV-18 observed here might be related to geographic and environmental factors or to race, peculiar aspects of our sample.…”

Prevalência do papilomavírus humano (HPV) em Belém, Pará, Brasil, na cavidade oral de indivíduos sem lesões clinicamente diagnosticáveis

“…O HPV 16 é o tipo mais comum associado ao câncer oral e ao de colo de útero, enquanto os tipos 6 e 11 são mais frequentes em lesões benignas e pré-malignas e raramente nas lesões neoplásicas da cabeça e do pescoço. Os achados comuns dos mesmos tipos de HPV (6,11, 16 e 18) em mucosa oral e genital são um forte indicativo para a transmissão orogenital 2,3,4 .…”

Human Papillomavirus as an Independent Predictor in Oral Squamous Cell Cancer

“…In 1983, human papillomavirus (HPV) was first described as a factor involved in the development of OSCC (Syrjänen et al, 1983). From then on, the presence of different types of HPV has been detected in oral cancers, which are mainly HPV16 and HPV18 with noticeable detection rates from 8% to 64% (Kansky, et al, 2003;Lo Muzio et al, 2004;Hansson et al, 2005). The presence of HPV DNA in a significant fraction of oral cancer, combined with the evidence that HPV status may affect the clinical outcomes in cervical or anogenital cancer patients (Lombard et al, 1998), led to a number of studies pointing a possible use of HPV diagnosis as an additional aid for survival prognosis in oral cancers (Schwartz et al, 2001;Ritchie et al, 2003), while other groups found no differences in survival by HPV status (Brandwein et al, 1994).…”