HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery

Abstract

There have been 4 reported cases of squamous cell carcinoma (SCC) of the neovagina in transgender women. In this report, we present another case of neovaginal SCC in a transgender woman, which was HPV-related, with lung metastasis as the initial presentation, and which was also complicated by her previous history of metastatic renal cell carcinoma. This unique case highlights the diagnostic challenges in these unusual scenarios. Through this report, we hope to address the benefits of multidisciplinary tumor board rounds, provision of detailed clinical information, and familiarization of the transgender anatomy within the pelvis in this group of patients. We also propose that transgender women undergo a continuous annual follow-up after postoperative follow-up is completed. mation surgery, vaginoplasty is usually done by penile and scrotal skin inversion [3]. There have been 4 cases of SCC of the neovagina in transgender women reported, all presented as neovaginal discharge or bleeding [4][5][6][7]. In this report, we present another case of neovaginal SCC in a transgender woman, with lung metastasis as the initial presentation. This case had also been further complicated by her previous history of metastatic renal cell carcinoma.

Influência da hormonioterapia na incidência de câncer em transexuais / Influence of hormone therapy on cancer incidence in transsexuals

“…A tabela 1 apresenta os dados referentes aos casos de CA em FtM após início da hormonioterapia para transição de mulher para homem com uso de hormônios exógenos. 43 30 NR NR NR NR NR Fiez (2019) 44 43 NR NR NR NR NR Wang (2020) 45 69 NR NR NR NR NR Lienhoop (2020) 46 74 + + -NR NR Elshim y(2020) 47 31 NR NR NR NR NR Nehlsen (2020) 48 53 e 2 casos acima de 60 anos. Para obtenção da média de tempo dos indivíduos que apresentaram uso hormonal antes do diagnostico, foram incluídos apenas 24 casos, devido à falta de informações do tempo de administração hormonal nos dois artigos mencionados, isto posto que a média foi de 6,2 entre 1-25 anos.…”

A Case of a Transwoman with Colorectal Cancer after Flap Vaginoplasty

“…Regarding the occurrence of malignant tumors after vaginoplasty, there are some reports of skin changes in the ne-ovagina and squamous cell carcinoma (including HPVpositive cases) in the neovagina [9][10][11][12] . In some cases, surgical treatment was successful; in others, the cancer was detected too late and the patient died despite chemotherapy and radiation therapy.…”

Sexually transmitted infections and the vaginal microbiome after vaginoplasty

“…Different effective condyloma acuminata treatment regimens have been described including laser treatments, cryotherapy, electrocautery, excision, imiquimod, and trichloroacetic acid [19 ▪ ,24,25]. HPV-associated lesions can lead to squamous epithelial lesions and squamous cell carcinoma, which have been described in TGD individuals with a history of vaginoplasty [26] including decades after surgery [27,28], and in the context of lung metastasis [29].…”