HPV vaccination to prevent anal cancer in men who have sex with men

Lawton, Mark D; Nathan, Mayura; Asboe, David

doi:10.1136/sextrans-2013-051176

Cited by 23 publications

(14 citation statements)

References 16 publications

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“…Human papillomavirus (HPV) infection is a leading cause of genital malignancies, and there are evidences showing a strong association between HPV infection and risk of HIV acquisition [Rositch et al, 2013;Videla et al, 2013]. Moreover, the incidence of anal cancer increased in men who have sex with men (MSM) compared to heterosexual men and in HIV infected individuals despite highly active antiretroviral treatment [Houlihan et al, 2012;Lawton et al, 2013;Hernandez et al, 2014]. Among these risk population groups, where life expectancy is reduced by non-HIV related morbidities [Ucciferri et al, 2012[Ucciferri et al, , 2013, HPV infections are generally caused by high-risk (HR) genotypes [De Vuyst et al, 2009;Ripabelli et al, 2010], particularly HPV-16.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of human papillomavirus type 58 in HIV infected men who have sex with men: A preliminary report in Central Italy

Sammarco

Ucciferri

Tamburro

et al. 2015

Journal of Medical Virology

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Human papillomavirus (HPV) infection and type-specific prevalence at anal, oral, coronal sulcus, and urethral mucosa in fifty HIV positive men having sex with men (MSM) were evaluated; patients were enrolled in a non-metropolitan area of Central Italy. Clinical and socio-demographic information, drug, and sexual behaviors were obtained for each participant. HPV was detected by PCR from an overall of 200 specimens, and genotyping was performed by both Restriction Fragment Length Polymorphism analysis and sequencing. HPV DNA was found in 60.0% (n = 30) of HIV positive MSM, and prevalence was higher at anal canal (n = 28, 56.0%) compared to all the other anatomical sites (χ(2) test P < 0.01) of coronal sulcus (n = 11, 22.0%), oral (n = 8, 16.0%), and urethral mucosa (n = 5, 10.0%). We found 63.3% (n = 19) of MSM with at least one high-risk genotype, and HPV-58 was more frequently detected (n = 9, 47.4%) respect to HPV-16 (n = 6, 31.6%). This is the first report on HPV detected at four anatomical sites involved in sexual practices in HIV positive MSM. We found an unusual distribution of oncogenic genotypes with an exceeding prevalence of HPV-58 respect to HPV-16. Hence, the recently licensed nonavalent vaccine should be suitable to prevent a larger number of infections caused by potentially emerging high-risk genotypes.

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Section: Introductionmentioning

confidence: 99%

High prevalence of human papillomavirus type 58 in HIV infected men who have sex with men: A preliminary report in Central Italy

Sammarco

Ucciferri

Tamburro

et al. 2015

Journal of Medical Virology

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“…One could infer from this that immunoreactivity to p16 in at least the squamous component of this leiomyosarcoma may have resulted in better response to radiotherapy and thus improved survival, however, larger studies are needed in p16 positive leiomyosarcomas at this location. Given that this tumor was associated with HPV subtypes 16 and 18, future cases such as this might be avoided by HPV vaccination prior to infection [16]. …”

Section: Discussionmentioning

confidence: 99%

A rare case of anal carcinosarcoma with human papilloma virus infection in both biphasic tumor elements: An immunohistochemical, molecular and ultrastructural study

Hickman

Bradshaw

Cassai

et al. 2016

Papillomavirus Research

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Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV). We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH) and further supported by electron microscopy (EM). Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation. Immunohistochemistry demonstrated that the epithelial component was positive for AE1/AE3, p63, CK5/6 and p16, whilst the mesenchymal component was positive for smooth muscle actin, vimentin, and focally positive for desmin and p16, consistent with carcinosarcoma. The tumor was negative for GATA-3, CK7 and CK20. CISH demonstrated that the tumor was positive for high risk HPV (subtype 16/18) in both tumor components. EM further supported the presence of intracellular virus particles (~50 nm) that is compatible with HPV infection. Infection of both epithelial and mesenchymal tumor components by HPV has not been previously observed in the gastrointestinal tract. This finding may represent initial epithelial HPV infection with subsequent divergent tumoral differentiation and suggests the presence of viral replication in both biphasic tumor components.

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“…In their Editorial in the journal Sexually Transmittted Infections , 3 UK researchers report that the risk of developing anal cancer is 15 times higher in homosexual than in heterosexual men. They suggest that targeted vaccination would be cost effective for the National Health System.…”

Section: Vaccinating Boys Against Hpv To Reduce Cancer Rates Across Tmentioning

confidence: 99%

Human Vaccines & Immunotherapeutics: News

Riedmann

2013

Human Vaccines & Immunotherapeutics

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Vaccinating boys against HPV to reduce cancer rates across the sexesNew melanoma vaccine contains natural product from marine spongesImpact of Hib conjugate vaccines in developing countriesElectronic Health Records to keep track of immunization statusPregnant women urged to get whooping cough vaccinationNew nano-coating developed to preserve vaccinesAlternative approach to creating a universal flu vaccineNew modular vaccine design: MAPS technology

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HPV vaccination to prevent anal cancer in men who have sex with men

Cited by 23 publications

References 16 publications

High prevalence of human papillomavirus type 58 in HIV infected men who have sex with men: A preliminary report in Central Italy

High prevalence of human papillomavirus type 58 in HIV infected men who have sex with men: A preliminary report in Central Italy

A rare case of anal carcinosarcoma with human papilloma virus infection in both biphasic tumor elements: An immunohistochemical, molecular and ultrastructural study

Human Vaccines & Immunotherapeutics: News

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