Hronotherapy Aspects of Efficiency Azilsartan Medoxomil in Combination Therapy in Patients With Hypertension and Metabolic Syndrome

Skibitskiy, V. V.; Фендрикова, А. В.; Сиротенко, Д. В.; Skibitskiy, A V

doi:10.18565/cardio.2016.10.35-40

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…The positive effect observed in this study supports the use of omega-3 in treating different pathologies of in ammatory disorder including arthritis (Mahmood et al, 2018), metabolic syndrome (Skibinski et al, 2016) and liver diseases (Hussein et al, 2017). We therefore conclude that omega-3-polyunsaturated fatty acid showed e cacy in anti-granuloma effects in chronic in ammation by its anti-proliferative activities.…”

Section: Discussionsupporting

confidence: 80%

Effects of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammation.

Omale

Ezeanyika

Nwanguma

et al. 2022

Preprint

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Recent advances have shown how PUFA regulate molecular signaling, especially in the context of inflammation. Nutritional interventions with PUFA in experimental animal models have exhibited anti-inflammatory properties. In this study, chronic inflammation was assayed by Cotton-Pellet Induced Granuloma to evaluate the anti-inflammatory and anti-granuloma effects of Omega-3-polyunsaturated fatty acid using experimentally induced inflammatory models in rats. Obtained results indicates that omega-3 oil extract significantly (p < 0.05) reduced the granuloma tissue formation (58.36 ± 3.52, 65.40 ± 1.30, 57.78 ± 3.89, 50.93 ± 0.60 and 42.17 ± 0.70mg representing 33.78, 25.79, 34.44, 42.21 and 52.15% inhibition respectively for the proliferative phase) when compared to the control. This results showed that omega-3 oil extract studied, posses both anti-inflammatory and anti-granuloma properties

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Section: Discussionsupporting

confidence: 80%

Effects of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammation.

Omale

Ezeanyika

Nwanguma

et al. 2022

Preprint

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“…[ 20 ] The present study revealed that morning hypertension was closely related to the recurrence of cerebral infarction, which is supported by recently published studies. [ 21 – 23 ] Physiologically, SBP and DBP usually increase slightly during awakening. If the blood pressure increases excessively in morning, it could have a greater impact on the vasculature.…”

Section: Discussionmentioning

confidence: 99%

Morning hypertension is a risk factor of macrovascular events following cerebral infarction

Qu²,

Yin³

et al. 2018

Medicine

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This study aimed to investigate risk factors (such as morning hypertension, drug compliance, and biochemical parameters) of macrovascular events after cerebral infarction.This was a retrospective study of patients with cerebral infarction admitted between May 2015 and April 2016 at the Fengxian Branch, 6th People's Hospital of Shanghai. They were divided into the macrovascular events and control groups according to the diagnosis of macrovascular events following cerebral infarction.Among the 702 patients included for analysis, 122 patients were with macrovascular events and 580 were without macrovascular events (controls). Morning hypertension (P = .01), dyslipidemia (P = .007), atrial fibrillation (P = .039), carotid artery plaque (P = .014), inflammatory infection (P = .005), high homocysteine (P = .032), antithrombotic compliance (P < .001), statins compliance (P < .001), morning diastolic blood pressure (P < .001), morning systolic blood pressure (P < .001), and morning heart rate (morHR) (P = .033) were associated with macrovascular events. Multivariable analysis showed that morning hypertension (P = .021, odds ratio [OR] = 1.753, 95% confidence interval [CI] [1.088, 2.826]), dyslipidemia (P = .021, OR = 1.708, 95% CI [1.085, 2.687]), and inflammatory infection (P = .031, OR = 2.263, 95% CI [1.078, 4.752]) were independent risk factors for macrovascular events, while antithrombotic compliance (P < .001, OR = 0.488, 95% CI [0.336, 0.709]), statin compliance (P = .02, OR = 0.64, 95% CI [0.44, 0.931]), and morHR (P = .027, OR = 0.977, 95% CI [0.958, 0.997]) were independent protective factors against macrovascular events. Atrial fibrillation showed a tendency to be associated with macrovascular events (P = .077, OR = 1.531, 95% CI [0.955, 2.454]).Morning hypertension, dyslipidemia, and inflammatory infection may increase the risk of macrovascular events following cerebral infarction. Improving morning blood pressure management and drug compliance (antithrombotic drugs and statins) may reduce the risk of macrovascular events following cerebral infarction.

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“…В нашем клиническом рандомизированном исследо-вании с участием 60 пациентов с АГ 1-2 степени при-менение азилсартана медоксомила в течение 3 меся-цев в комбинации с диуретиком сопровождалось не только улучшением основных показателей суточ-ного мониторирования АД, оптимизацией суточного профиля АД, но и достоверным уменьшением систо-лического, диастолического и среднего АД в аорте, индекса аугментации, а также скорости распростра-нения пульсовой волны [16]. Кроме того, нами оце-нивались возможности хронотерапевтического под-хода у данной категории пациентов.…”

Section: современные возможности антигипертензивной терапии: место азunclassified

Modern Opportunities for Antihypertension Therapy: The Place of Azilsartan Medoxomil

Скибицкий¹,

Фендрикова²

2017

Russ J Cardiol

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Hronotherapy Aspects of Efficiency Azilsartan Medoxomil in Combination Therapy in Patients With Hypertension and Metabolic Syndrome

Cited by 11 publications

References 8 publications

Effects of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammation.

Effects of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammation.

Morning hypertension is a risk factor of macrovascular events following cerebral infarction

Modern Opportunities for Antihypertension Therapy: The Place of Azilsartan Medoxomil

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