Immobilizing a protein, that is fully compatible with the patient, on the surface of a biomedical device should make it possible to avoid adverse responses such as inflammation, rejection, or excessive fibrosis. A surface that strongly binds and does not denature the compatible protein is required. Hydrophilic surfaces do not induce denaturation of immobilized protein but exhibit a low binding affinity for protein. Here, we describe an energetic ion-assisted plasma process that can make any surface hydrophilic and at the same time enable it to covalently immobilize functional biological molecules. We show that the modification creates free radicals that migrate to the surface from a reservoir beneath. When they reach the surface, the radicals form covalent bonds with biomolecules. The kinetics and number densities of protein molecules in solution and free radicals in the reservoir control the time required to form a full protein monolayer that is covalently bound. The shelf life of the covalent binding capability is governed by the initial density of free radicals and the depth of the reservoir. We show that the high reactivity of the radicals renders the binding universal across all biological macromolecules. Because the free radical reservoir can be created on any solid material, this approach can be used in medical applications ranging from cardiovascular stents to heart-lung machines.

Technological and scientific challenges coupled with environmental considerations have attracted a search for robust, green and energy-efficient synthesis and processing routes for advanced functional nanomaterials. In this article, we demonstrate a high-energy ball milling technique for large-scale synthesis of nitrogen doped carbon nanoparticles, which can be used as an electro-catalyst for oxygen reduction reactions after a structural refinement with controlled thermal annealing. The resulting carbon nanoparticles exhibited competitive catalytic activity (5.2 mA cm(-2) kinetic-limiting current density compared with 7.6 mA cm(-2) on Pt/C reference) and excellent methanol tolerance compared to a commercial Pt/C catalyst. The proposed synthesis route by ball milling and annealing is an effective process for carbon nanoparticle production and efficient nitrogen doping, providing a large-scale production method for the development of highly efficient and practical electrocatalysts.

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Plastic scintillators have many advantages for dosimetry in external beam radiotherapy. The current method of transmitting the scintillation light to a remote detector is through a solid core optical fibre. When exposed in a high energy therapeutic radiotherapy beam this fibre is subject to an unwanted background signal from Cerenkov light which can exceed the scintillation signal at characteristic angles. We have constructed a plastic scintillation dosimeter that uses an air core light guide to transport the light from the scintillator to the light detector. We show that there is sufficient signal propagation in the air core light guide to allow the scintillator signal to be carried outside the primary beam of a radiotherapy linear accelerator and for a dosimeter to be constructed using a scintillator inserted into the end of the light guide. Studies of the background light generated in the air core light guide, as a function of the angle between the beam and the fibre axis, show that there is no characteristic Cerenkov peak generated in the air core. Depth dose measurements using the air core scintillation dosimeter with no correction for Cerenkov are compared to ionization chamber measurements for a 6 MV photon beam and a 9 MeV electron beam.