Microstructural responses of In0.32Ga0.68N and In0.9Ga0.1N films to 2.25 GeV Xe ion irradiation have been investigated using X-ray diffraction, Raman scattering, ion channeling and transmission electron microscope. It is found that the In-rich In0.9Ga0.1N is more susceptible to irradiation than Ga-rich In0.32Ga0.68N. The Xe ion irradiation with a fluence of 7×1011 ions/cm2 leads to little damage in In0.32Ga0.68N, but an obvious lattice expansion in In0.9Ga0.1N. The level of lattice disorder in In0.9Ga0.1N increases after irradiation, which is due to the huge electronic energy deposition of the incident Xe ions. However, no Xe ion tracks are observed to be formed, which is attributed to the very high velocity of 2.25 GeV Xe ions. Point defects and/or small defect clusters are likely the dominating defect type in the Xe-irradiated In0.9Ga0.1N.