Hsa_circ_0001925 promotes malignant progression in triple‐negative breast cancer via <scp>miR</scp>‐1299/<scp>YY1</scp> axis

Shen, Bin‐jie; Yang, Yi‐fei; Zhang, Xiu‐xia

doi:10.1111/1759-7714.14803

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…They observed that miR-1299 interacted with the 3'UTR of YY1, and overexpression of YY1 partially counteracted the effect of miR-1299 overexpression on breast cancer progression. Silencing Hsa_circ_0001925 could reduce YY1 expression by decreasing sponge miR-1299, thereby inhibiting cell proliferation, migration, and angiogenesis and promoting apoptosis in vitro ( 36 ).…”

Section: Molecular Mechanism Of Circrna In Breast Cancermentioning

confidence: 99%

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Li,

Zhang,

et al. 2024

Transl Cancer Res

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Background and Objective Breast cancer is presently the most prevalent cancer and the leading cause of cancer-related deaths in women worldwide. Circular RNA (circRNA) is a class of closed circRNAs lacking a 5'-end cap structure and a 3'-end polyA tail, which is highly stable and widely involved in a variety of pathophysiological processes such as cell proliferation, differentiation, and apoptosis. In recent years, accumulating studies have shown that circRNAs play an important role in the development and prognosis of breast cancer, but there are fewer literature reviews on their intrinsic molecular mechanisms which is the aim of this study. Methods This review synthesizes the findings of literature retrieved from searches of PubMed and Google Scholar databases, hand searches, and authoritative texts. Citations mainly originate from the past 3 years. The articles need to describe the role of circRNA in breast cancer; no language restrictions were imposed. Key Content and Findings This review summarizes the latest relevant literature and systematically reviews the four main mechanisms of circRNA in breast cancer from the perspective of circRNA function. At the same time, we describe the formation mechanism, characterization, and biological functions of circRNAs. Conclusions We reviewed the status of actual knowledge about circRNA biogenesis and functions and summarized novel findings regarding the molecular mechanism of circRNA in breast cancer. Meanwhile, this review explores the possibility of circRNAs for becoming new biodiagnostic indicators and therapeutic targets in breast cancer.

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Section: Molecular Mechanism Of Circrna In Breast Cancermentioning

confidence: 99%

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Li,

Zhang,

et al. 2024

Transl Cancer Res

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show abstract

“…Also, miR-1299 was down-regulated in BC and up-regulated miR-1299 expression inhibited BC progression [32] . Also, circ_0001925 expedited cell processes in BC through miR-1299 sponging mechanism to mediate YY1 [33] . Consistently, our expression detection suggested that miR-1299 was down-regulated in BC tissues.…”

Section: Groupmentioning

confidence: 99%

Croton Alkaloids Suppresses Breast Cancer Cell Proliferation, Migration and Invasion through mediating Circular_0079593

Yanjiang,

Liu,

Liu

et al. 2024

IJPS

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Effects of Croton Alkaloids on Breast Cancer Cells To investigate the effects of croton alkaloids on malignant behaviors of breast cancer cells T47D and the possible mechanism. Different doses of croton alkaloids were exposed to T47D cells. T47D cells were transfected with small interfering-circular_0079593 and small interfering-negative control by liposome transfection, respectively. The plasmid cloning deoxyribonucleic acid-circular_0079593 transfected T47D cells were performed with 150 μg/ ml croton alkaloids treatment. Circular_0079593 and microRNA-1299 were determined via qualitative reverse transcription polymerase chain reaction in breast cancer samples and cells. 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay and colony formation assay for proliferation, scratch assay for migration and transwell assay for invasion were performed. Circular_0079593 and microRNA-1299 target relationship was examined using dual-luciferase reporter assay. Protein analysis was implemented through Western blot. Croton alkaloids increased cell proliferation inhibition rate and E-cadherin protein level (p<0.05) while reduced colony formation number and invasive cells (p<0.05), and croton alkaloids suppressed scratch healing rate and N-cadherin protein level (p<0.05), and these effects were dose-dependent. Circular_0079593 up-regulation and microRNA-1299 down-regulation were detected in breast cancer tissues contrasted to adjacent samples (p<0.05). Croton alkaloids induced circular_0079593 expression up-regulation (p<0.05) and microRNA-1299 level inhibition (p<0.05) in a dose-dependent manner. Circular_0079593 could targeted regulate the expression of microRNA-1299. Transfection of small interfering-circular_0079593 elevated microRNA-1299 level, and suppressed cell malignant behaviors. Circular_0079593 overexpression could weaken the regulation of croton alkaloids in T47D cell behaviors. Croton alkaloids could repress breast cancer cell proliferation, colony formation, migration and invasion via mediating circ_0079593/microRNA-1299 axis.

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Hsa_circ_0001925 promotes malignant progression in triple‐negative breast cancer via miR‐1299/YY1 axis

2023

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Background Circular RNAs (circRNAs) are related to the pathogenesis and progression of triple‐negative breast cancer (TNBC). The aim of this study was to investigate the role and mechanism of hsa_circ_0001925 in TNBC progression. Methods Hsa_circ_0001925, microRNA (miR)‐1299 and Yin Yang 1 (YY1) levels were examined in TNBC via reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) and western blot. Cell counting kit‐8 (CCK‐8), colony formation, 5‐ethynyl‐2′‐deoxyuridine (EdU) staining, flow cytometry, wound healing assay and tube formation assay were conducted to estimate the effects of hsa_circ_0001925 on malignant phenotypes of TNBC tumors. Several protein levels were measured with western blot. The regulatory relationship between miR‐1299 and hsa_circ_0001925 or YY1 was validated using a dual‐luciferase reporter and RNA immunoprecipitation (RIP) assays. Xenograft assay was used to estimate the effect of hsa_circ_0001925 in TNBC in vivo. Results Hsa_circ_0001925 and YY1 levels were upregulated, while miR‐1299 abundance was downregulated in TNBC tissues and cells. Hsa_circ_0001925 silencing constrained cell proliferation, migration and angiogenesis whereas it promoted apoptosis in vitro, and hsa_circ_0001925 silencing significantly curbed xenograft tumor growth in vivo. Hsa_circ_0001925 acted as a miRNA sponge for miR‐1299. Hsa_circ_0001925 decreased YY1 expression by sponging miR‐1299. MiR‐1299 downregulation alleviated the effects of hsa_circ_0001925 knockdown on BC progression. MiR‐1299 interacted with the 3′ untranslated region (3′ UTR) of YY1, and YY1 overexpression partly reversed the effects of miR‐1299 overexpression on BC progression. Conclusion Our findings showed that hsa_circ_0001925 mediated TNBC progression via regulating miR‐1299/YY1 axis, providing a potential target for BC treatment.

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Hsa_circ_0001925 promotes malignant progression in triple‐negative breast cancer via miR‐1299/YY1 axis

Cited by 4 publications

References 30 publications

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Molecular mechanisms of circular RNA in breast cancer: a narrative review

Croton Alkaloids Suppresses Breast Cancer Cell Proliferation, Migration and Invasion through mediating Circular_0079593

Hsa_circ_0001925 promotes malignant progression in triple‐negative breast cancer via miR‐1299/YY1 axis

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