Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA‐223

Zhang, Yi; Xia, Lei; Wu, Jing; Xu, Xinyu; Li, Gang

doi:10.1002/jcla.23428

Cited by 6 publications

(3 citation statements)

References 22 publications

(22 reference statements)

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“…Li et al 22 demonstrated the downregulation of hsa_circ_0001017 and hsa_circ_0061276 in GC tissues and plasma by RT‐droplet digital PCR (ddPCR). Zhang et al 23 reported that hsa_circ_0023642 was upregulated in GC and correlated with malignant progression of GC by acting as a miR‐223 sponge. Zhang et al 24 reported that circLARP4 can facilitate the expression of miR‐424‐5p target LATS1 and YAP by acting as a sponge of miR‐424‐5p.…”

Section: Discussionmentioning

confidence: 99%

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Shi

Song

Ding

2021

Clinical Laboratory Analysis

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Background Circular RNAs (circRNAs) are a novel family of endogenous RNAs. Recent studies have demonstrated that circRNAs are potential novel biomarkers for diagnosing cancers. However, little is known about the role of circRNAs in gastric cancer (GC). This study aimed to identify the relationship between GC and a new circRNA named hsa_circ_001888. Methods Hsa_circ_001888 expression levels were measured by quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) in GC cell lines, tissues, and plasma samples. Then, the associations between the expression level of hsa_circ_001888 and the clinicopathological features of patients with GC were further investigated. A receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic value of hsa_circ_001888. Results In this study, hsa_circ_001888 was first found to be significantly downregulated in GC cell lines (AGS and MKN‐45), tissues, and plasma samples compared to control samples. Clinicopathological features showed that the expression of hsa_circ_001888 in GC tissues was associated with differentiation and in GC plasma linked with serum CEA and CA19‐9 levels. The areas under the ROC curves of hsa_circ_001888 in tissues and plasma were 0.654 and 0.66, respectively. Conclusions Hsa_circ_001888 may serve as a potential biomarker in the diagnosis of GC and may be involved in GC development.

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Section: Discussionmentioning

confidence: 99%

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Shi

Song

Ding

2021

Clinical Laboratory Analysis

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“… 15 Similarly, circHN1, circMAN2B2, and hsa_circ_0023642 were also found to affect the growth and migration of GC cells by the similar ways. 16 , 17 , 18 All these circRNAs can serve as potential biomarkers and targets for the diagnosis and therapy of GC, which strongly suggests an important role of altered circRNAs in cancer pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0001874 is an indicator for gastric cancer

et al. 2021

Clinical Laboratory Analysis

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Background Recent studies have indicated that circular RNAs (circRNAs) are novel endogenous RNAs whose 5′ and 3′ ends are covalently linked and play critical roles in gastric carcinogenesis. However, the significance of circRNA hsa_circ_0001874 in gastric cancer (GC) is still unclear. Methods Therefore, we first detected hsa_circ_0001874 levels in GC cell lines and tissues and analyzed their potential correlation with clinicopathological factors. Then, a receiver operating characteristic (ROC) curve was established to evaluate its clinical value. Finally, we further predicted the biological functions of this molecule by bioinformatics analysis. Results Our data showed that as an indicator, hsa_circ_0001874 expression was significantly decreased in 78.02% (71/91) of the GC patients. Combined with clinicopathological factors, the hsa_circ_0001874 level was strongly associated with cell differentiation (p < 0.001), tumor stage (p = 0.005), invasion (p = 0.024), lymphatic metastasis (p = 0.023), and CEA level (p < 0.001) in GC tissues. The area under the curve (AUC) was up to 0.673, with a sensitivity and specificity of 61.54% and 68.13%, respectively. Bioinformatics analysis showed that hsa_circ_0001874 harbors miR‐593‐5p, miR‐103a‐3p, and miR‐107 seed sequences to regulate these three miRNAs and downstream target genes and exert its various biological functions in the carcinogenesis and progression of GC. Conclusion In summary, these data suggest that hsa_circ_0001874 is an indicator of GC and plays a significant role in gastric carcinogenesis and progression.

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“… 13 It was also revealed that circ_0023642 contributed to GC development via interaction with miRNA-223. 14 Ding et al reported that circCSNK1G1 was one of the markedly upregulated circRNAs in GC. 15 However, the biological role of circCSNK1G1 in GC is still unclear.…”

Section: Introductionmentioning

confidence: 99%

CircCSNK1G1 Contributes to the Tumorigenesis of Gastric Cancer by Sponging miR-758 and Regulating ZNF217 Expression

Feng¹,

Li²

2021

CMAR

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Background Increasing evidence indicates that circular RNAs (circRNAs) act as vital regulators in various cancers. Nevertheless, the effect of circCSNK1G1 on gastric cancer (GC) is still unknown. Methods The mRNA levels of circCSNK1G1, miR-758, and ZNF217 were measured by RT-qPCR. The protein levels of ZNF217 were evaluated by Western blotting. Cell migration, invasion, proliferation, and apoptosis were detected by Transwell, CCK-8, and flow cytometry assays. The association between miR-758 and circCSNK1G1/ZNF217 was confirmed by RIP and luciferase reporter assays. Xenograft assay was employed for in vivo experiment. Results In the current study, it was demonstrated that the expression levels of circCSNK1G1 and ZNF217 were upregulated in GC tissues and cells, while the level of miR-758 was declined. Furthermore, functional assays indicated that circCSNK1G1 depletion suppressed GC progression in vitro and in vivo. In addition, circCSNK1G1 directly interacted with miR-758, and the supplementation of miR-758 suppressed the development of GC, which was abolished following pcDNA3.1-circCSNK1G1 transfection. Then, we explored the downstream mechanism of miR-758 and found that miR-758 could target the 3′UTR of ZNF217 mRNA. The overexpression of miR-758 neutralized the ZNF217-mediated effects on facilitating the progression of GC. Finally, we revealed that circCSNK1G1 could upregulate ZNF217 expression by sponging miR-758 in GC cells. Conclusion Our study revealed that circCSNK1G1 accelerated GC progression via the miR-758/ZNF217 axis, suggesting that circCSNK1G1 might be a potential biomarker for GC diagnosis and treatment.

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Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA‐223

Cited by 6 publications

References 22 publications

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Circular RNA hsa_circ_0001874 is an indicator for gastric cancer

CircCSNK1G1 Contributes to the Tumorigenesis of Gastric Cancer by Sponging miR-758 and Regulating ZNF217 Expression

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