Hsa_circ_0042666 inhibits proliferation and invasion via regulating miR-223/TGFBR3 axis in laryngeal squamous cell carcinoma

Wei, Zhenxing; Chang, Kunpeng; Fan, Chongsheng

doi:10.1016/j.biopha.2019.109365

Cited by 27 publications

(20 citation statements)

References 28 publications

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“…Lately, it is surveyed that downregulation of miR-18a is capable of discouraging NPC proliferation, invasion, and migration [4]. Additionally, a decrease in TGFBR3 expression is regarded to link with laryngeal squamous cell carcinoma (LSCC) invasion and miR-223/TGFBR3 axis regulation takes part in LSCC progression inhibition [32]. TGFBR3 elevation is documented to restrict NPC cell viability, induce apoptosis, and activate pro-apoptosis signaling pathways [14].…”

Section: Discussionmentioning

confidence: 99%

microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGF-β Signaling Pathway

Peng

Liu

et al. 2020

Nanoscale Res Lett

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Objectives Nasopharyngeal carcinoma (NPC) is a type of nasopharyngeal disease with high metastasis and invasion properties. Tumor-associated alternative activated (M2) macrophages are evidenced to connect with NPC. Based on this, this study purposes to explore the mechanism and participation of microRNA-18a (miR-18a) from M2 macrophages in NPC. Methods Peripheral blood mononuclear cells were differentiated to macrophages and macrophages were polarized to M2 type by interleukin-4. SUNE-1 and CNE2 cells were transfected with restored or depleted miR-18a or transforming growth factor-beta III receptor (TGFBR3) to explore their roles in NPC progression with the involvement of the TGF-β signaling pathway. Next, SUNE-1 and CNE2 cells were co-cultured with M2 macrophages that had been treated with restored or depleted miR-18a or TGFBR3 to comprehend their combined roles in NPC with the involvement of the TGF-β signaling pathway. Results MiR-18a was highly expressed and TGFBR3 was lowly expressed in NPC cells. MiR-18a restoration, TGFBR3 knockdown or co-culture with miR-18a mimics, or si-TGFBR3-transfected M2 macrophages promoted SUNE-1 cell progression, tumor growth in mice, decreased p-Smad1/t-Smad1, and elevated p-Smad3/t-Smad3. miR-18a downregulation, TGFBR3 overexpression, or co-culture with miR-18a inhibitors or OE-TGFBR3-transfected M2 macrophages depressed CNE2 cell progression, tumor growth in mice, increased p-Smad1/t-Smad1, and decreased p-Smad3/t-Smad3. Conclusion Our study elucidates that miR-18a from M2 macrophages results in promoted NPC cell progression and tumor growth in nude mice via TGFBR3 repression, along with the Smad1 inactivation and Smad3 activation.

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Section: Discussionmentioning

confidence: 99%

microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGF-β Signaling Pathway

Peng

Liu

et al. 2020

Nanoscale Res Lett

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“…In prostate cancer, breast cancer, renal cell carcinoma and endometrial cancer, TGFBR3 has been identified as a tumor suppressor gene [ 19 – 24 ]. Wei Z found that hsa_circ_0042666 regulated laryngeal squamous cell carcinoma (LSCC) cell proliferation and invasion by the miR-223/TGFBR3 axis [ 25 ]. HOXC13 has been reported to be correlated with progression from leukoplakia to OFSCC arising in the Gingivo Buccal Complex (GBC) with integrative genome-wide analysis [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Construction and analysis of a competing endogenous RNA network to reveal potential prognostic biomarkers for Oral Floor Squamous Cell Carcinoma

Zhang

Shi

et al. 2020

PLoS ONE

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Background Patients diagnosed with Oral Floor Squamous Cell Carcinoma (OFSCC) face considerable challenges in physiology and psychology. This study explored prognostic signatures to predict prognosis in OFSCC through a detailed transcriptomic analysis. Method We built an interactive competing endogenous RNA (ceRNA) network that included lncRNAs, miRNAs and mRNAs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to predict the gene functions and regulatory pathways of mRNAs. Least absolute shrinkage and selection operator algorithm (LASSO) analysis and Cox regression analysis were used to screen prognosis factors. The Kaplan-Meier method was used to analyze the survival rate of prognosis factors. Risk score was used to assess the reliability of the prediction model. Results A specific ceRNA network consisting of 56 mRNAs, 16 miRNAs and 31 lncRNAs was established. Three key genes (HOXC13, TGFBR3, KLHL40) and 4 clinical factors (age, gender, TNM, and clinical stage) were identified and effectively predicted the for survival time. The expression of a gene signature was validated in two external validation cohorts. The signature (areas under the curve of 3 and 5 years were 0.977 and 0.982, respectively) showed high prognostic accuracy in the complete TCGA cohort.

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“…Laryngeal squamous cell cancer (LSCC) is the most common type of LC with a relatively high mortality rate and poor survival rate [ 48 ]. The current standard treatment strategies have significantly improved the quality of life of LSCC patients, and the overall five-year survival rate remains unsatisfactory [ 49 ]. Some researchers discovered that circRNAs may provide a novel sight to LSCC.…”

Section: Circular Rnas In Head and Neck Cancersmentioning

confidence: 99%

“…CircRASSF2 maybe a potential biomarker for the diagnosis and prognosis of LSCC, and further underlying mechanisms are needed to be investigated in the future. Based on the works of Tian et al's group [ 50 ], Wei and colleagues found that the expression level and function of hsa_circ_0042666 in LSCC were lower compared to adjacent nontumor tissues [ 49 ]. Functionally, they proved that the down-regulation of hsa_circ_0042666 is related to advanced tumor stage, lymph node metastasis, and poor overall survival in LSCC patients.…”

Section: Circular Rnas In Head and Neck Cancersmentioning

confidence: 99%

The Research Progression and Clinical Significance of Circular RNAs in Head and Neck Cancers

Dan-hui

2020

BioMed Research International

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With rapid development of science technique and molecular research, a large number of circular RNAs (circRNAs) were discovered. CircRNAs that are a heterogeneous endogenous group of non-coding RNA not only are abundantly and diffusely expressed in mammals but also participate in many biological processes, such as in tumor ingenuity and progress. CircRNAs have rarely open reports in the head and neck cancers (HNC), which are an aggressive malignant tumor with unsatisfactory overall survival rates. The diagnostics and treatments continue to improve while the survival rate of HNC patients has no more obvious improvement. Recent studies that are aimed at exploring the molecular mechanisms of occurrence and progression of circRNAs in HNC provide a valuable insight into potential novel diagnostic and therapeutic approaches. In this review, we summarize the increasing number of published researches on the research progression of circRNAs in HNC, as well as their possible clinical implications on HNC.

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Hsa_circ_0042666 inhibits proliferation and invasion via regulating miR-223/TGFBR3 axis in laryngeal squamous cell carcinoma

Cited by 27 publications

References 28 publications

microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGF-β Signaling Pathway

microRNA-18a from M2 Macrophages Inhibits TGFBR3 to Promote Nasopharyngeal Carcinoma Progression and Tumor Growth via TGF-β Signaling Pathway

Construction and analysis of a competing endogenous RNA network to reveal potential prognostic biomarkers for Oral Floor Squamous Cell Carcinoma

The Research Progression and Clinical Significance of Circular RNAs in Head and Neck Cancers

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