Hsa_circ_0050102 regulates the pancreatic cancer development via miR‐218‐5p/PPME1 axis

Abstract

Pancreatic cancer (PC) is a common cancer with great morbidity and mortality. 1 The incidence of PC is closely related to smoking, genetics, diabetes, obesity, diet, age and other factors. [2][3][4][5] Besides, the occurrence of PC rises with age, with almost 90% of cases happening in people over 55. 6,7 Therefore, we urgently need to find a new way to treat and diagnose PC.Circular RNAs (circRNAs) are RNAs that play vital special effects in lots of diseases. 8,9 For instance, hsa_circ_0050102 had stimulative effects in PC. 10 Besides, circ-LDLRAD3 was a marker in the judgement of PC. 11 CircNFIB1 inhibited lymphatic metastasis in PC. 12 In addition, circPDE8A promoted invasive growth in PC. 13 Circ_000864 could repress the migration and invasion in PC. 14 But, the regulatory mode of hsa_circ_0050102 on PC is not clear. MicroRNAs (miRNAs) have been described in a lot of diseases. 15,16 For example, miR-218-5p regulated the progress of PC. 17Besides, miR-218-5p regulated the sensitivity to gemcitabine in gallbladder cancer. 18 Moreover, miR-218-5p acted as a marker in PC. 19 Moreover, miR-218-5p took part in adjusting osteosarcoma cancer advancement. 20 However, the effect of miR-218-5p in PC is indistinct.Protein phosphatase methylesterase 1 (PPME1) is a PP2Aspecific methylesterase, which is an important regulator of tumorigenesis. 21 For instance, PPME1 acted as an innovative healing target in gastric and lung cancer. 22 Besides, PPME1 regulated the