Hsa_circ_0093884 bound to RNA-binding protein RPS3 ameliorates hepatocyte inflammation in anti-tuberculosis drug-induced liver injury by competitively activating SIRT1

Yang, Luming; Wang, Lin; Tang, Qinyan; Liu, Yue; Meng, Chen; Sun, Shiqun; Chong, Yingzhi; Zhang, Yiyang; Fang, Feng

doi:10.1016/j.intimp.2022.109018

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…MicroRNAs such as miR-19b, miR-128-3p, miR-485-3p, and miR-133a also modulate SIRT1 expression ( Liu et al, 2019a ; Zhao et al, 2020 ; Chen et al, 2020a ; Tang et al, 2023 ). Moreover, Yang et al (2022a) discovered that hsa_circ_0093884, a circular RNA derived from the NAD + -dependent deacetylase, enhances SIRT1 levels through the depletion of ribosomal protein S3 (RPS3).…”

Section: Survey Methodologymentioning

confidence: 99%

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

Wang,

Zhao,

Chen

et al. 2024

PeerJ

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Liver disease is a common and serious threat to human health. The progression of liver diseases is influenced by many physiologic processes, including oxidative stress, inflammation, bile acid metabolism, and autophagy. Various factors lead to the dysfunction of these processes and basing on the different pathogeny, pathology, clinical manifestation, and pathogenesis, liver diseases are grouped into different categories. Specifically, Sirtuin1 (SIRT1), a member of the sirtuin protein family, has been extensively studied in the context of liver injury in recent years and are confirmed the significant role in liver disease. SIRT1 has been found to play a critical role in regulating key processes in liver injury. Further, SIRT1 seems to cause divers outcomes in different types of liver diseases. Recent studies have showed some therapeutic strategies involving modulating SIRT1, which may bring a novel therapeutic target. To elucidate the mechanisms underlying the role of sirtuin1 in liver injury and its potentiality as a therapeutic target, this review outlines the key signaling pathways associated with sirtuin1 and liver injury, and discusses recent advances in therapeutic strategies targeting sirtuin1 in liver diseases.

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Section: Survey Methodologymentioning

confidence: 99%

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

Wang,

Zhao,

Chen

et al. 2024

PeerJ

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“…Typical circRNAs involved References p53/p21 pathway circCEA, circMYH9, circWSB1, circ_kif26b [97,[108][109][110] p16/Rb pathway circ_0014717, circZFR, ciPVT1 [105, 111,112] mTOR pathway circMBOAT2, circIPO7, circZKSCAN1, circZNF609 [113][114][115][116] AMPK pathway circ_002581, circWHSC1, circ_0057558, circACC1 [117][118][119][120] NF-κB pathway circARHGEF28, circRNF10, circ_103124, circNFKB1, circPLCE1 [121][122][123][124][125] Sirtuins pathway circRACGAP1, circ_0093884, circ_0018553, circITCH [126][127][128][129] Abbreviations: circRNAs, circular RNAs; CS, cellular senescence.…”

Section: Pathwaysmentioning

confidence: 99%

“…126 hsa_circ_0093884 recruited ribosomal protein S3 (RPS3) to increase sirtuin-1 (SIRT1) expression. 127 hsa_circ_0018553 promoted sirtuin-2 (SIRT2) expression by acting as a sponge for miR-4731. 128 circITCH was found to function as an endogenous sponge of miR-330-5p, thereby increasing the expression of sirtuin-6 (SIRT6).…”

Section: Sirtuins Signaling Pathwaymentioning

confidence: 99%

“…For instance, circRACGAP1 enhanced the stability and expression of sirtuin‐3 (SIRT3) by recruiting polypyrimidine tract‐binding protein 1 (PTBP1) 126 . hsa_circ_0093884 recruited ribosomal protein S3 (RPS3) to increase sirtuin‐1 (SIRT1) expression 127 . hsa_circ_0018553 promoted sirtuin‐2 (SIRT2) expression by acting as a sponge for miR‐4731 128 .…”

Section: Circular Rnas Regulate Cellular Senescence Via Various Pathwaysmentioning

confidence: 99%

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Cellular senescence: A potential mode of circular RNAs regulating prostate cancer

Li,

Fan,

Zhang

et al. 2023

MedComm – Oncology

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Cellular senescence is a state characterized by permanent cell cycle stoppage, which has long been viewed as a protective mechanism against neoplasia. However, accumulating evidence reveal that cellular senescence variously stimulates tumorigenesis and malignant progression in certain contexts. Senescence‐associated secretory phenotype (SASP) is a crucial feature of senescent cells and the main way they function. Prostate cancer (PCa) is apparently an age‐related tumor with a high prevalence in the elderly. With the aggravation of population aging the morbidity of PCa continues to rise. And with the progress of the disease, most patients eventually develop castration‐resistant PCa (CRPC) or drug resistance, which poses a challenge for the treatment of PCa and aggravates the burden on patients and society. Circular RNAs (circRNAs) are a class of endogenous noncoding RNAs formed by back‐splicing of pre‐mRNAs. Characterized by special covalently closed circular structure, they play important regulatory roles in various tumors. Numerous studies have revealed that circRNAs can regulate PCa and cellular senescence in diverse ways. This review explores a potential mode that circRNAs regulate PCa, reveales a significant mechanism of tumorigenesis and progression for PCa, suggesting a new strategy for PCa research.

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“…An upregulated circRNA among them, circMARS, was found to play roles in the compensatory repair mechanism of ADLI through the circMARS–miR-6808-5p/-6874-3p/-3157-5p–KMT2C–EGFR function axis. Another study published in this year found a down-regulated circRNA in ADLI patients called has_circ_0093884 could upregulate the expression of an anti-inflammatory protein SIRT1 by binding ribosomal protein S3 and thus regulate the hepatocyte inflammation in ADLI ( 60 ).…”

Section: The Role Of Circrnas In Tuberculosismentioning

confidence: 99%

Emerging roles of circular RNAs in tuberculosis

et al. 2022

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Tuberculosis (TB) remains a major global health issue, resulting in around 1.5 million people deaths each year. Better diagnostic and therapeutic tools are urgently needed. Circular RNAs (circRNAs) are a new class of noncoding RNAs with a covalently closed structure, and exhibit a tissue-, cell-, and developmental stage-specific expression pattern. Recently, circRNAs were thought to be regulatory molecules implicated in the onset and progression of a series of human diseases including tuberculosis. In tuberculosis, circRNAs have been shown to regulate host anti-TB immune responses, such as decreasing monocyte apoptosis, enhancing autophagy and promoting macrophage polarization. Importantly, circRNAs are physically stable and abundant in several types of body fluids. Therefore they are considered as promising minimally-invasive biomarkers. In this review, we focus on the recent advances in the immune regulatory roles of circRNAs, as well as their potential diagnostic value in TB.

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Hsa_circ_0093884 bound to RNA-binding protein RPS3 ameliorates hepatocyte inflammation in anti-tuberculosis drug-induced liver injury by competitively activating SIRT1

Cited by 6 publications

References 37 publications

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic target

Cellular senescence: A potential mode of circular RNAs regulating prostate cancer

Emerging roles of circular RNAs in tuberculosis

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