HTLV-Iii in Symptom-Free Seronegative Persons

Salahuddin, S. Z.; Pd, Markham; Redfield, R.; Essex, M.; Groopman, JeromeE.; Sarngadharan, M. G.; Mclane, MaryF.; Sliski, Ann; Gallo, RobertC.

doi:10.1016/s0140-6736(84)91619-2

Cited by 231 publications

(58 citation statements)

References 9 publications

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“…When immunological function is restored, KS can regress. It is known that HIV infection tests can be negative in hypogammaglobulinemic cases and at an early stage of HIV-infection (12)(13)(14). In our patient, however, repeated tests for anti-HIV antibodies were negative and the gammaglobulin levels were normal during the two years' duration of illness.…”

Section: Kaposi's Sarcoma In the Course Of Juvenile Myelodysplastic Scontrasting

confidence: 49%

Kaposi's Sarcoma in the Course of Juvenile Myelodysplastic Syndrome

et al. 1995

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Section: Kaposi's Sarcoma In the Course Of Juvenile Myelodysplastic Scontrasting

confidence: 49%

Kaposi's Sarcoma in the Course of Juvenile Myelodysplastic Syndrome

et al. 1995

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“…For example, this could conceivably happen with some hemophiliacs who receive repeated treatment with processed blood products. In view of the importance of identifying potential virus carriers, it should be noted that the presence of serum antibodies to HTLV-III is not an absolute determining factor in identifying virus-infected individuals since, in infrequent instances, virus has been isolated from clinically normal, seronegative donors (19).…”

Section: Discussionmentioning

confidence: 99%

Isolation of infectious human T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and from healthy carriers: a study of risk groups and tissue sources.

Salahuddin¹,

Markham²,

Popovič³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

131

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Acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) are thought to be caused by human T-cell leukemia/lymphotropic virus type III (HTLV-Ill). Since (helper/inducer) lymphocytes were preferentially infected and were subjected to a characteristic cytopathic effect. The availability of multiple isolates of virus from a number of different patients and donors will greatly facilitate the characterization of HTLV-III and the study of possible biological and/or biochemical variants of the virus responsible for the development of AIDS, ARC, and related diseases.

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“…In fact, eight patients with AIDS have already been recognized by the Ministry of Health and Welfare of Japan, among whom five were hemophiliacs and the remainder male homosexuals. Almost all patients infected with LAV possessed antibody to the virus in their sera although the occurrence of seronegative but virus-positive persons without clinical symptoms has been reported (18). However, this virus is transmitted by blood transfusion and injection of plasma products despite of the presence of antibody to the virus in blood, and the development of AIDS in infants born to apparently healthy antibody-positive mothers was reported (11).…”

Section: Resultsmentioning

confidence: 99%

Distribution of the Level of Antibody to AIDS‐Associated Virus (LAV) in Sera from AIDS or AIDS Related Complex and Japanese Hemophiliacs Infected with AIDS‐Associated Virus

Tsuchie

Kawatani

Erika

et al. 1985

Microbiology and Immunology

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The level of antibody to AIDS-associated virus (LAV) in sera from patients with AIDS or AIDS related diseases (AIDS related complex; ARC) and Japanese hemophiliacs was studied using indirect immunofluorescence.Titer of anti-LAV antibody in sera from 89 patients with AIDS or ARC ranged between 10 and 40,960 (median : 1,280) and that of 83 Japanese hemophiliacs ranged from 20 to 20,480(median : 640). The distribution of the level of anti-LAV antibody in hemophiliacs was similar to that of patients with AIDS or ARC, and no correlation between the titer of antibody and the presence of symptoms of AIDS was observed.Our results suggested that hemophiliacs in Japan might have been infected with live LAV rather than been immunized with inactivated LAV by injection of factor VIII or IX concentrate, and more hemophiliacs in Japan might show symptoms of AIDS in the future as in the United States.

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HTLV-Iii in Symptom-Free Seronegative Persons

Cited by 231 publications

References 9 publications

Kaposi's Sarcoma in the Course of Juvenile Myelodysplastic Syndrome

Kaposi's Sarcoma in the Course of Juvenile Myelodysplastic Syndrome

Isolation of infectious human T-cell leukemia/lymphotropic virus type III (HTLV-III) from patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) and from healthy carriers: a study of risk groups and tissue sources.

Distribution of the Level of Antibody to AIDS‐Associated Virus (LAV) in Sera from AIDS or AIDS Related Complex and Japanese Hemophiliacs Infected with AIDS‐Associated Virus

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