Many aspects of society were impacted by the COVID-19 pandemic, including physical health, psychological well-being, social dynamics, and the economy. The construction sector experienced a significant influence from the pandemic. This research aimed to analyze the relationship between psychosocial factors (individual, home, and work factors) and the level of work distress among construction sector workers during the COVID-19 pandemic. This study employed a quantitative analytical approach with a cross-sectional design. Data collection took place in November–December 2021, and the total sample that met the inclusion criteria was 110 respondents. Work distress and psychosocial data were collected using a questionnaire that had undergone validity and reliability tests. Univariate analyses (frequency distribution), bivariate analyses (chi-square test), and multivariate analyses (multiple logistic regression tests) were conducted to analyze the data. The research revealed that the most closely related variables to the work distress levels were work duration, followed by employment status and career opportunities. This study underscores the importance of regulating working hours and providing opportunities for permanent employment and career advancement for the mental health of construction workers.