Hubungan Kadar Albumin Plasma Dan Gula Darah Dengan Sepsis Neonatorum

Wowor, Ester Elisabeth; Rompis, Johnny; Wilar, Rocky

doi:10.35790/ebm.1.1.2013.1623

“…Based on the distribution of albumin examination, the hypoalbuminemia category in neonatal sepsis patients, which is 74.2%, is more than the normal albumin category (25.8%). This is in line with research conducted by Wowor et al (2013) at Prof. Dr. R. D. Kandou Manado Hospital, with a description of the results of albumin examination of 16 neonatorium sepsis patients, 75% had hypoalbuminemia and 25% with normal albumin levels, and showed there was a relationship between albumin levels and neonatorum sepsis (p: 0.001). Likewise, research conducted by Lorencia et al (2019) on neonatal sepsis patients, with the results of 76.1% hypoalbuminemia and 23.9% with normal albumin levels.…”

Section: Resultssupporting

confidence: 93%

“…The occurrence of inflammation in endothelial cells results in vasodilation of smooth muscle, and can increase vascular permeability and cause capillary leakage. This leakage can lead to the diffusion of albumin from the inside to the outside of the vasculature, which can lead to a decrease in albumin in the blood (Wowor et al, 2013). Albumin, a single protein consisting of 610 or more amino acids (Nugraha, 2017), is the most abundant protein in the human body (55-60% of all plasma proteins).…”

Section: Introductionmentioning

confidence: 99%

“…Based on the results of research by Wowor et al (2013), a description of the results of albumin examination in 38 patients, of 16 neonatal sepsis patients there were 75% experiencing hypoalbuminemia and 25% with normal albumin levels, 22 non-sepsis patients 22.7% experienced hypoalbuminemia and 77.3% with normal albumin levels. In the research journal Lorencia et al (2019), found the results of 76.1% hypoalbuminemia and 23.9% with normal albumin levels in neonatal sepsis patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Albumin Levels and Leukocyte Counts in The Incident of Neonatal Sepsis

Sulaiman,

Haryanto,

Endarini

2023

JAMBS

0

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Background: Sepsis can affect all age, but is most common in young infants and neonates. Young infants and neonates are more susceptible to infection because their immune systems are immature, unable to localize infections, and lack the IgM needed to protect the body against bacterial infections. When experiencing neonatal sepsis, there is often an increase in leukocytes in response to infection and inflammation, where inflammation can also cause a decrease in albumin in the blood. Objective: This study aims to analyze the relationship between albumin levels and leukocyte counts in the incidence of neonatal sepsis. Methods: The research method used analytic correlation with a cross sectional approach. A sample of 31 patients with neonatal sepsis who were treated at Waluyo Jati hospital, Probolinggo Regency in December 2022 - April 2023 were sampled using saturation sampling method. Results: The results of the study on neonatal sepsis based on laboratory examinations mostly occurred in conditions of leukocytosis (45.2%) and hypoalbuminemia (77.4%), while the results of the study based on Pearson correlation test analysis obtained a significant value (p) of 0.737 (α=0.05). Conclusion: there is no relationship between albumin levels and leukocyte counts in neonatal sepsis.

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“…Pasien yang mengalami hipoalbuminemia pada penelitian ini berjumlah 54 bayi (76,1%). Hipoalbuminemia juga didapatan lebih banyak pada penelitian prospektif dilakukan oleh Wowor et al 35 36 Singh et al 37 juga melakukan penelitian di Nepal yang bertujuan untuk melihat prevalensi hipoalbuminemia pada keseluruhan pasien rawat inap dan rawat jalan berdasarkan usia dan jenis kelamin. Penelitiannya mendapatkan 454 (89,72%) dari 506 pasien laki-laki yang mengalami hipoalbuminemia dan 386 (88,12%) dari 438 pasien perempuan yang juga mengalami hipoalbuminemia.…”

Section: Hasil Penelitianunclassified

Gambaran Fungsi Hati pada Sepsis Neonatorum di RSUP Prof. Dr. R. D. Kandou Manado

Lorencia¹,

Manoppo²,

Umboh³

2019

eCl

1

0

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Neonatal sepsis is a clinical syndrome that consists of nonspecific symptoms and infection signs, occuring with bacteremia in the first 28 days of life. SGOT and SGPT abnormalities as well as hypoalbuminemia can be found in neonatal sepsis patients. This study was aimed to obtain the overview of liver function especially SGOT, SGPT and albumin in neonatal sepsis patients at NICU of Prof. Dr. R. D. Kandou Hospital. This was a retrospective and descriptive study. Data were obtained from the patients’ medical records. The results showed that the percentage of sepsis patients that had mild increased SGOT level was 47.9%. Meanwhile, the SGPT level was more often normal (81.7%). Hypoalbuminemia was found in 54 patients (76.1%), more frequent in male infants (80.9%). Increased SGOT and SGPT levels were more frequent in male infants; 51.1% for mild increased SGOT and 12.8% for mild increased SGPT. In conclusion, among neonatal sepsis increased SGOT levels were more often in mild form meanwhile increased SGPT levels were rare. Increased SGOT and SGPT levels and decreased albumin levels were more common among male infants.Keywords: SGOT, SGPT, albumin, neonatal sepsis Abstrak: Sepsis neonatorum merupakan sindroma klinis yang terdiri dari gejala-gejala nonspesifik dan tanda-tanda infeksi, terjadi bersamaan dengan bakteremia pada 28 hari pertama kehidupan. Abnormalitas SGOT dan SGPT serta hipoalbuminemia dapat ditemukan pada pasien sepsis neonatorum. Penelitian ini bertujuan untuk mengetahui gambaran fungsi hati secara khusus SGOT, SGPT, dan albumin pada pasien sepsis neonatorum di NICU RSUP Prof. Dr. R.D. Kandou. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien sepsis neonatorum. Hasil penelitian mendapatkan persentase pasien sepsis yang mengalami peningkatan ringan kadar SGOT sebesar 47,9%. Kadar SGPT lebih sering ditemukan normal (81,7%). Hipoalbuminemia dijumpai pada 54 pasien (76,1%), lebih sering pada bayi laki-laki (80,9%). Peningkatan SGOT dan SGPT berdasarkan jenis kelamin lebih sering pada bayi laki-laki dan dalam bentuk peningkatan ringan yaitu sebesar 51,1% untuk SGOT dan 12,8% untuk SGPT. Simpulan penelitian ini ialah pada pasien sepsis neonatorum peningkatan kadar SGOT paling sering dalam bentuk peningkatan ringan sedangkan peningkatan kadar SGPT jarang didapatkan. Peningkatan ringan SGOT dan SGPT serta penurunan albumin lebih sering dijumpai pada bayi laki-laki.Kata kunci: SGOT, SGPT, albumin, sepsis neonatorum

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“…Pasien yang mengalami hipoalbuminemia pada penelitian ini berjumlah 54 bayi (76,1%). Hipoalbuminemia juga didapatan lebih banyak pada penelitian prospektif dilakukan oleh Wowor et al 35 di NICU RSUP Prof Dr. R. D. Kandou Manado tahun 2013 terhadap pasien yang terdiagnosis sepsis, yaitu dari 16 pasien yang mengalami sepsis neonatorum, 12 (75,0%) mengalami hipoalbuminemia sedangkan 4 (25,0%) memiliki kadar albumin normal. Penelitian yang dilakukan oleh Yang et al, 11 melaporkan bahwa dari 32 pasien sepsis neonatorum, sebanyak 27 (86,0%) mengalami hipoalbuminemia.…”

Section: Bahasanunclassified

Gambaran Fungsi Hati pada Sepsis Neonatorum di RSUP Prof. Dr. R. D. Kandou Manado

Lorencia¹,

Manoppo²,

Umboh³

2019

eCL

0

View full text Add to dashboard Cite

Neonatal sepsis is a clinical syndrome that consists of nonspecific symptoms and infection signs, occuring with bacteremia in the first 28 days of life. SGOT and SGPT abnormalities as well as hypoalbuminemia can be found in neonatal sepsis patients. This study was aimed to obtain the overview of liver function especially SGOT, SGPT and albumin in neonatal sepsis patients at NICU of Prof. Dr. R. D. Kandou Hospital. This was a retrospective and descriptive study. Data were obtained from the patients’ medical records. The results showed that the percentage of sepsis patients that had mild increased SGOT level was 47.9%. Meanwhile, the SGPT level was more often normal (81.7%). Hypoalbuminemia was found in 54 patients (76.1%), more frequent in male infants (80.9%). Increased SGOT and SGPT levels were more frequent in male infants; 51.1% for mild increased SGOT and 12.8% for mild increased SGPT. In conclusion, among neonatal sepsis increased SGOT levels were more often in mild form meanwhile increased SGPT levels were rare. Increased SGOT and SGPT levels and decreased albumin levels were more common among male infants.Keywords: SGOT, SGPT, albumin, neonatal sepsis Abstrak: Sepsis neonatorum merupakan sindroma klinis yang terdiri dari gejala-gejala nonspesifik dan tanda-tanda infeksi, terjadi bersamaan dengan bakteremia pada 28 hari pertama kehidupan. Abnormalitas SGOT dan SGPT serta hipoalbuminemia dapat ditemukan pada pasien sepsis neonatorum. Penelitian ini bertujuan untuk mengetahui gambaran fungsi hati secara khusus SGOT, SGPT, dan albumin pada pasien sepsis neonatorum di NICU RSUP Prof. Dr. R.D. Kandou. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien sepsis neonatorum. Hasil penelitian mendapatkan persentase pasien sepsis yang mengalami peningkatan ringan kadar SGOT sebesar 47,9%. Kadar SGPT lebih sering ditemukan normal (81,7%). Hipoalbuminemia dijumpai pada 54 pasien (76,1%), lebih sering pada bayi laki-laki (80,9%). Peningkatan SGOT dan SGPT berdasarkan jenis kelamin lebih sering pada bayi laki-laki dan dalam bentuk peningkatan ringan yaitu sebesar 51,1% untuk SGOT dan 12,8% untuk SGPT. Simpulan penelitian ini ialah pada pasien sepsis neonatorum peningkatan kadar SGOT paling sering dalam bentuk peningkatan ringan sedangkan peningkatan kadar SGPT jarang didapatkan. Peningkatan ringan SGOT dan SGPT serta penurunan albumin lebih sering dijumpai pada bayi laki-laki.Kata kunci: SGOT, SGPT, albumin, sepsis neonatorum

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Hubungan Kadar Albumin Plasma Dan Gula Darah Dengan Sepsis Neonatorum

Cited by 3 publications

References 11 publications

Relationship Between Albumin Levels and Leukocyte Counts in The Incident of Neonatal Sepsis

Relationship Between Albumin Levels and Leukocyte Counts in The Incident of Neonatal Sepsis

Gambaran Fungsi Hati pada Sepsis Neonatorum di RSUP Prof. Dr. R. D. Kandou Manado

Gambaran Fungsi Hati pada Sepsis Neonatorum di RSUP Prof. Dr. R. D. Kandou Manado

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