Hubungan Kadar FSH dengan Gambaran Spermatogenik pada Pasien Azoospermia Berdasarkan Kriteria Johnson

Birowo, Ponco; Jelita, Namira Kesuma; Sari, Pudji; Rasyid, Nur

doi:10.23886/ejki.5.7667.

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“…Congress of the Asia Pacific Initiative on Reproduction (2016) also states that an increase in serum FSH levels and a decrease in testosterone are associated with abnormal spermatogenesis [29]. The value of FSH levels if > 10.36 mIU/ml has a sensitivity of 82.1% with a specificity of 79.5% for azoospermia [12]. Similar studies also found that increasing FSH levels could adversely affect the reproduction of male mice [30].…”

Section: Effect Of Administration Of Ethanol Extract Of Marigold Leav...mentioning

confidence: 97%

“…Also explains that oxidative stress from cigarette smoke can cause infertility in men. Spermatogenesis is strongly influenced by the role of FSH, namely by stimulating Sertoli cells to produce ABP, inhibin synthesis, glycoprotein synthesis, and energy metabolism, and then produces lactic acid which is a source of energy for spermatogenic cells reported that the laboratory reference for normal adult men is (FSH 1.38-9.58 mIU/ml) [11][12][13]. Marigold (Tagetes erecta) or often called the kotok flower as shown in Figure 1 is a plant that grows wild on plantations or around the house [14] indicated that marigold is a type of medicinal plant that contains flavonoids, polyphenols, and two types of carotenoids, namely carotenes, and xanthophylls [15,16].…”

Section: Introductionmentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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Cigarette smoke produces particles such as nicotine, tar, and cadmium which can damage male germ cells and interfere with the hypothalamus, pituitary, and testicles which cause spermatogenesis disorders. The study aimed to analyze the differences in FSH levels in each group of mice (Mus musculus) exposed to cigarette smoke by administering ethanol extract from marigold leaves (Tegetes erecta). The laboratory experimental research method used a Randomized post-test-only control group design with exposure to one cigarette smoke 1 cigarette per day and administration of ethanol extract of marigold leaves (Tegetes erecta). The grouping of research samples used simple random sampling in 5 groups with experimental mice (Mus Musculus) males aged 8-12 weeks and weighing 20-25 grams which were divided into 5 groups, namely K(-) (placebo), K(+) (smoked cigarettes and placebo), P1 (cigarette smoke and marigold leaf extract dose 0.25 g/kg-BW), P2 (smoked cigarettes and marigold leaf extract dose 0.50 g/kg-BW), and P3 (smoked cigarettes and marigold leaf extract dose 1, 0 g/kg-BW). FSH levels were examined using ELISA. The results of the analysis of examining FSH levels showed an average of K(-): 0.80 mIU/ml, K(+): 0.60 mIU/ml, P1: 0.54 mIU/ml (dose 0.25 g/kg-BW), P2:0.60 mIU/ml (dose of 0.50 g/kg-BW), and P3:0.55 mIU/ml (dose of 1.0 g/kg-BW) with p-value ≤0.05. In conclusion, there was a significant effect of the administration of ethanol extract of marigold leaves (Tegetes erecta) on the FSH levels of mice exposed to cigarette smoke.

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Section: Effect Of Administration Of Ethanol Extract Of Marigold Leav...mentioning

confidence: 97%