Latar belakang: Para petani penyemprot di Desa Bumen, Kecamatan Sumowono setiap harinya selalu melakukan kontak dengan pestisida. Paparan pestisida kepada para petani penyemprot di Desa Bumen dapat menyebabkan timbulnya gejala gangguan neurologis. Sebagian besar petani tersebut memiliki riwayat gejala gangguan neurologis, seperti tremor, merasa sangat lelah di luar kebiasaan, sensitif, kebas pada tangan dan kaki, dan lupa hal baru saja terjadi. Selain itu, terdapat anggota keluarga yang sering lupa akan hal yang baru saja terjadi, dan mengharuskan mereka mencatat hal-hal penting. Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang berhubungan dengan kejadian gangguan neurologis akibat pestisida pada petani di Desa Bumen, Kecamatan Sumowono, Kabupaten Semarang.Metode: Penelitian ini adalah penelitian observasional yang bersfiat analitik dengan desain penelitian cross-sectional. Populasi penelitian pada penelitian ini sebanyak 363 petani penyemprot. Teknik pengambilan sampel menggunakan simple random sampling, sehingga diperoleh subjek penelitian 76 petani penyemprot. Instrumen yang digunakan pada penelitian ini yaitu kuesioner Q18 Jerman yang telah dimodifikasi sesuai dengan budaya setempat. Teknik analisis data yang digunakan dalam penelitian ini meliputi analisis univariat dan analisis bivariate dengan uji chi-square.Hasil: Hasil penelitian menunjukkan bahwa sebanyak 46 petani (60,52%) mengalami gejala gangguan neurologis. Terdapat hubungan yang signifikan antara masa kerja (p-value= 0,009), dosis pestisida (p-value= 0,032), jenis pestisida (p-value= 0,009), dan cara pencampuran pestisida (p-value= 0,002) dengan gejala neurologis pada para petani. Tidak ada hubungan lama penyemprotan (p-value= 0,64), frekuensi penyemprotan (p-value= 0,638), posisi menyemprot (p-value- =1,000), kelengkapan APD (p-value= 0,85), dan penyimpanan pestisida dengan kejadian gangguan neurologis pada petani di Desa Bumen.Simpulan: Terdapat sebanyak 4 variabel yang terbukti memiliki hubungan dengan kejadian gangguan neurologis pada petani di Desa Bumen. Variabel tersebut yaitu masa kerja, dosis pestisida, jenis pestisida, dan cara pencampuran pestisida. ABSTRACT Title: Factors Related to the Incident of Neurological Disorders in Farmers (Study on Farmers in Bumen Village, Sumowono District, Semarang Regency)Background: Spraying farmers in Bumen Village, Sumowono District always come into contact with pesticides every day. Exposure to pesticides by spraying farmers in Bumen Village can cause symptoms of neurological disorders. Most of these farmers have a history of symptoms of neurological disorders, such as tremors, feeling unusually tired, sensitive, numb in the hands and feet, and forgetting what has just happened. In addition, there are family members who often forget what has just happened, and require them to record important things. This research aims to determine what factors are associated with the incidence of neurological disorders due to pesticides in farmers in Bumen Village, Sumowono District, Semarang Regency.Method: This research is an analytical observational study with a cross-sectional research design. The research population in this study was 363 spray farmers. The sampling technique used simple random sampling, so that the research subjects were 76 spraying farmers. The instrument used in this research is the German Q18 questionnaire which has been modified according to local culture. The data analysis techniques used in this research include univariate analysis and bivariate analysis with the chi-square test.Result: The results showed that as many as 46 farmers (60.52%) experienced symptoms of neurological disorders. There is a significant relationship between work period (p-value= 0.009), pesticide dose (p-value= 0.032), type of pesticide (p-value= 0.009), and method of mixing pesticides (p-value= 0.002) with neurological symptoms in the farmers. There is no relationship between spraying time (p-value= 0.64), spraying frequency (p-value= 0.638), spraying position (p-value- =1.000), completeness of PPE (p-value= 0.85), and storage pesticides with the incidence of neurological disorders in farmers in Bumen Village.Conclusion: There are 4 variables that have been proven to have a relationship with the incidence of neurological disorders in farmers in Bumen Village. These variables are work period, pesticide dose, type of pesticide, and method of mixing the pesticide.