Patient safety is an issue related to health services that has been considered a global problem and must be a priority in the provision of health services in hospitals. Until now, patient safety incident reports in Indonesia still show a high incidence. In this case, nursing staff as health workers will be the main determining factor in determining the quality of patient safety system implementation, because they have more frequent interaction time with patients than other health workers. Meanwhile, there are still many nurses who do not implement patient safety. Objective: to determine the factors that influence the implementation of patient safety by nurses in hospitals. Method: This research uses a literature review method. Data was searched through a search on Google Scholar using the keywords, namely "Factors" AND "Nurse" AND "Patient Safety" AND "Hospital". Searches on ScienceDirect use the keywords, namely “Factor” AND “Nurse” AND “Patient Safety” AND “Hospital. The references used are literature published within the last 5 years (2019-2013). Results: Based on the results of a review of six selected pieces of literature, it was found that factors that can influence the implementation of patient safety by nurses can be grouped into 2 categories, namely individual level factors and organizational level factors. Conclusion: Based on the 2 known factor categories, factor optimization must be carried out accompanied by evaluation of the work system related to these factors, so that it will minimize the occurrence of Patient Safety Incidents.