Hubungan Prokalsitonin dan Rasio Neutrofil Limfosit dengan Mortalitas  Pneumonia di Ruang Rawat Intensif Anak Rumah Sakit Umum Pusat Haji Adam Malik Medan

Adilla, Nadya Riqqoh; Lubis, Aridamuriany Dwiputri

doi:10.14238/sp23.6.2022.390-4

2022

DOI: 10.14238/sp23.6.2022.390-4

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Hubungan Prokalsitonin dan Rasio Neutrofil Limfosit dengan Mortalitas Pneumonia di Ruang Rawat Intensif Anak Rumah Sakit Umum Pusat Haji Adam Malik Medan

Nadya Riqqoh Adilla

Aridamuriany Dwiputri Lubis²

Abstract: Latar belakang. Pneumonia merupakan penyebab kematian 808.694 anak dibawah 5 tahun pada tahun 2017 di dunia. Rerata jumlah kematian harian balita akibat pneumonia pada tahun 2007 adalah 83 anak. Peningkatan kadar prokalsitonin (PCT) secara signifikan berhubungan dengan peningkatan mortalitas, begitu pula dengan rasio neutrofil limfosit (NLR) yang merupakan parameter sederhana untuk menilai status inflamasi subjek dan dapat memperkirakan mortalitas 30 hari pasien Community Acquired Pneumonia (CAP) khususnya pad… Show more

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Cited by 3 publications

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“…There have been many studies conducted regarding the Neutrophil-Lymphocyte Ratio (NLR) as a predictor of mortality in pediatric patients. Increased levels of neutrophils and apoptosis of lymphocyte cells are often found in patients with systemic inflammation or disorders that make the NLR increase (7)(8)(9). A study by Mathews et al (2018) (10) stated that a simple and inexpensive marker, such as an increase in NLR helps in predicting PICU mortality comparable to PELOD score 2.…”

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confidence: 99%

Correlation of Neutrophil Lymphocyte Ratio and Monocyte Lymphocyte Ratio to the Pelod-2 Score in Critically Ill Children

Miraza,

Buana,

Evalina

et al. 2023

IJRP

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Critically ill children admitted to the pediatric intensive care unit (PICU) from 75 to 166 per 100,000 children/year including respiratory diseases, infectious diseases, congenital diseases, and perioperative care. Early detection of disease severity in critically ill children uses the PELOD-2 score. Previous studies have shown that neutrophil lymphocyte ratio (NLR) can be used as a predictor of pediatric mortality and monocyte and lymphocyte ratio (MLR) to determine the severity of Klebsiella pneumonia infection. The aim of this study is to determine the correlation of NLR and MLR to PELOD-2 score in critically ill children in the PICU of Haji Adam Malik General Hospital. The research method is cross sectional analytic research from medical records, then documentation of PELOD-2 scores. The subjects were critically ill children from October to December 2022 according to the inclusion and exclusion criteria. Data were analyzed with the Spearman correlation test. Results: A total of 59 pediatric patients, the most was female 34 patients (57.6%). The mean age of the children was 6.23 years old. With the most indications was respiratory disease 22 people (37.3%). Spearman correlation test analysis showed that there was no significant correlation between NLR and MLR with PELOD 2 on the first day (p=0.316 and p=0.696) and MLR with PELOD 2 on the third day of treatment (p=0.077). However, a significant correlation was found between NLR and PELOD 2 in critically ill children on the third day of care (p=0.014). Conclusion: There was a significant correlation between NLR and PELOD-2 score on the third day of care. However, there was no correlation between first and third day MLR and first day NLR with PELOD-2 score.

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mentioning

confidence: 99%

Correlation of Neutrophil Lymphocyte Ratio and Monocyte Lymphocyte Ratio to the Pelod-2 Score in Critically Ill Children

Miraza,

Buana,

Evalina

et al. 2023

IJRP

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Correlation between Leukocyte Count and Lymphatic Neutrophil Ratio to Procalcitonin in Covid-19 Confirmed Patients at Gresik Regional General Hospital

Verdiana

Puspitasari

2023

ijins

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Covid-19 is a new type of virus that attacks the respiratory system and can infect humans, which can cause respiratory illness and death from acute pneumonia. Hematology and procalcitonin are laboratory investigations that are often used. This study aims to determine the relationship between the results of the examination of the leukocyte count and the ratio of neutrophil lymphocytes to procalcitonin in patients with confirmed Covid-19. This type of research uses a cross sectional design using a purposive random sampling technique that uses secondary data. Research data collection was carried out in June 2022 at the Ibnu Sina Gresik Hospital Laboratory. Statistical test using Spearman correlation test. Based on the results of the study, it was found p = 0.481, indicating that the results were not statistically significant with the correlation coefficient (r) showing a negative value of 0.134, so it can be concluded that there is a very weak relationship between the number of leukocytes and procalcitonin in patients with confirmed Covid-19. A decrease in the number of leukocytes by 1 cell/µl can increase procalcitonin levels by 0.134 ng/ml and based on the results p = 0.491 indicating that the results are not statistically significant with a correlation coefficient value (r) of 0.131 so that it shows a very weak correlation between the ratio relationship neutrophil lymphocytes to procalcitonin in patients with confirmed Covid-19.

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Analysis of Neutrophil/Lymphocyte Ratio and Culture Results on Clinical Severity of Patients with CAP

Afiah

Handayani

Kadir

2023

Indonesian J. Clin. Pathol. Med. Lab.

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Community-Acquired Pneumonia (CAP) is an acute infection with high morbidity and mortality, especially among toddlers and elders in Indonesia. Culture is the gold standard for infectious diseases, which requires a long time. Therefore, a rapid, inexpensive, easy-to-use marker such as NLR is needed. To analyze the relationship of NLR and culture results with the clinical severity of CAP. A retrospective study with a cross-sectional design was performed using secondary data from CAP patients at Dr. Wahidin Sudirohusodo Hospital from January 1st, 2018 to July 31st, 2021. The study conducted on 113 samples showed no significant differences between NLR and clinical severity of CAP (p-value of 0.071). However, the mean value of NLR in severe CAP was higher (6±4.74) than in moderate CAP (2.58±1.8) with no significant correlation (p-value 0.071). There was a significant difference in culture on the clinical severity of CAP (p-value 0.005). A positive correlation was found between culture and clinical severity of CAP (p-value 0.004) with weak correlation strength (r=0.266). NLR is an early detection marker of infection. Stimulation of growth hormone causes an increase in neutrophil count, apoptosis acceleration, and lymphocyte redistribution; therefore, increased neutrophils are common in severe clinical conditions. The insignificant relationship between NLR and clinical severity might be caused by the therapeutic intervention given. The ATS/IDSA guidelines stated that culture results were positive in 4-15%. The mean NLR value in severe CAP was slightly higher than that of moderate CAP, but no significant difference was found. There was a weak correlation between culture results and the clinical severity of CAP patients.

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Hubungan Prokalsitonin dan Rasio Neutrofil Limfosit dengan Mortalitas Pneumonia di Ruang Rawat Intensif Anak Rumah Sakit Umum Pusat Haji Adam Malik Medan

Cited by 3 publications

References 16 publications

Correlation of Neutrophil Lymphocyte Ratio and Monocyte Lymphocyte Ratio to the Pelod-2 Score in Critically Ill Children

Correlation of Neutrophil Lymphocyte Ratio and Monocyte Lymphocyte Ratio to the Pelod-2 Score in Critically Ill Children

Correlation between Leukocyte Count and Lymphatic Neutrophil Ratio to Procalcitonin in Covid-19 Confirmed Patients at Gresik Regional General Hospital

Analysis of Neutrophil/Lymphocyte Ratio and Culture Results on Clinical Severity of Patients with CAP

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