Teenagers are prone to premarital sexual behavior problems. SDKI in 2017 reported premarital sexual behavior of 59% in women and 74% in men. Premarital sexual behavior in adolescents can be influenced by school knowledge, attitudes, and roles. This behavior affects cases of HIV/AIDS, abortion, and early marriage. According to the Indonesia National Population and Family Planning Board has report 14.2 million teenage girls make weddings every year, one of them is in Batu City. The number of early marriages in Batu City is increasing. One of the high schools in Batu City there has been a violation of norms due to premarital sexual behavior, poor school programs and activities in the field of reproductive health that can affect youth's knowledge, attitudes and behavior. The purpose of this study was to find the relationship between the level of knowledge of adolescent reproductive health, adolescent attitude and school role and premarital sexual behavior. The study used a cross-sectional design with a sample of 41 students and students obtained from the total sampling population. The chi-square test results show that there is a relationship between reproductive health knowledge variables, attitudes and roles of schools and premarital sexual behavior. In the multivariate test results, the adolescent attitude variable was the most influential variable in premarital sexual behavior.