HULC targets the IGF1R–PI3K-AKT axis in trans to promote breast cancer metastasis and cisplatin resistance

Li, Hui; Sun, Tingge; Xue, Wei; Niu, Chao; Li, Min; Li, Wei; Hoffman, Andrew R.; Hu, Ji-Fan; Cui, Jiuwei

doi:10.1016/j.canlet.2022.215861

Cited by 31 publications

(9 citation statements)

References 41 publications

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“…As reported previously, long noncoding RNA NBR2 regulated the polarization of tumor-associated macrophages, decreased proliferation, and inhibited migration in colorectal cancer both in vitro and in vivo, which supported our present results. Besides regulation of macrophage polarization, NBR2 was demonstrated to regulate autophagy, suppress migration and invasion, and inhibit epithelial-mesenchymal transition progression in hepatocellular carcinoma, colorectal cancer, osteosarcoma, and nonsmall cell lung cancer, respectively. − In addition, recent studies unveiled that many LncRNAs acted as oncogenic or carcinostatic factors in human breast cancer, such as HOTAIR, HULC, SEMA3B-AS1, TGFB2-AS1 etc. − We herein provided evidence that LncRNA NBR2 decreased in MWCNTs-stimulated macrophages, participating in macrophage M2 polarization and consequently promoted metastasis of breast cancer cells. However, the exact mechanism of the downregulation of NBR2 induced by MWCNT exposure in macrophages still needs to be further explored.…”

Section: Discussionmentioning

confidence: 71%

Multiwalled Carbon Nanotubes-Reprogrammed Macrophages Facilitate Breast Cancer Metastasis via NBR2/TBX1 Axis

Ding,

Zhu,

Yan

et al. 2024

ACS Nano

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In recent years, carbon nanotubes have emerged as a widely used nanomaterial, but their human exposure has become a significant concern. In our former study, we reported that pulmonary exposure of multiwalled carbon nanotubes (MWCNTs) promoted tumor metastasis of breast cancer; macrophages were key effectors of MWCNTs and contributed to the metastasis-promoting procedure in breast cancer, but the underlying molecular mechanisms remain to be explored. As a follow-up study, we herein demonstrated that MWCNT exposure in breast cancer cells and macrophage coculture systems promoted metastasis of breast cancer cells both in vitro and in vivo; macrophages were skewed into M2 polarization by MWCNT exposure. LncRNA NBR2 was screened out to be significantly decreased in MWCNTs-stimulated macrophages through RNA-seq; depletion of NBR2 led to the acquisition of M2 phenotypes in macrophages by activating multiple M2-related pathways. Specifically, NBR2 was found to positively regulate the downstream gene TBX1 through H3k27ac activation. TBX1 silence rescued NBR2-induced impairment of M2 polarization in IL-4 & IL-13-stimulated macrophages. Moreover, NBR2 overexpression mitigated the enhancing effects of MWCNT-exposed macrophages on breast cancer metastasis. This study uncovered the molecular mechanisms underlying breast cancer metastasis induced by MWCNT exposure.

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Section: Discussionmentioning

confidence: 71%

Multiwalled Carbon Nanotubes-Reprogrammed Macrophages Facilitate Breast Cancer Metastasis via NBR2/TBX1 Axis

Ding,

Zhu,

Yan

et al. 2024

ACS Nano

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“…Besides, except PIK3CA and AKT, we also found IGF1R, MAPK1, JAK3, STAT5A and ESR1 have a relatively higher binding affinity with LEO components. IGF1R is a trans -membrane tyrosine kinase receptor and frequently up-regulated in breast cancer [ 27 ]. The interaction between the molecules IGF-I and IGF-II, along with the receptor IGF1R, triggers powerful signals that promote cell growth and prevent cell death via the pathways PI3K/AKT and RAS/MAPK [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer

Maitisha,

Zhou,

Zhao

et al. 2023

Heliyon

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“…Zhou et al. demonstrated that lncRNA HULC can increase H3K9 acetylation in the promoter region of IGF1R in the nucleus, thereby activating IGF1R transcription, which in turn causes activation of the downstream PI3K/AKT pathway ( 121 ). DLEU1 is highly expressed in breast cancer and is subject to two epigenetic modifications to regulate its expression.…”

Section: Interactions Between Ncrnas and Other Epigenetic Modificatio...mentioning

confidence: 99%

Emerging roles of interactions between ncRNAs and other epigenetic modifications in breast cancer

Xie,

Gan,

Xue

et al. 2023

Front. Oncol.

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Up till the present moment, breast cancer is still the leading cause of cancer-related death in women worldwide. Although the treatment methods and protocols for breast cancer are constantly improving, the long-term prognosis of patients is still not optimistic due to the complex heterogeneity of the disease, multi-organ metastasis, chemotherapy and radiotherapy resistance. As a newly discovered class of non-coding RNAs, ncRNAs play an important role in various cancers. Especially in breast cancer, lncRNAs have received extensive attention and have been confirmed to regulate cancer progression through a variety of pathways. Meanwhile, the study of epigenetic modification, including DNA methylation, RNA methylation and histone modification, has developed rapidly in recent years, which has greatly promoted the attention to the important role of non-coding RNAs in breast cancer. In this review, we carefully and comprehensively describe the interactions between several major classes of epigenetic modifications and ncRNAs, as well as their different subsequent biological effects, and discuss their potential for practical clinical applications.

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HULC targets the IGF1R–PI3K-AKT axis in trans to promote breast cancer metastasis and cisplatin resistance

Cited by 31 publications

References 41 publications

Multiwalled Carbon Nanotubes-Reprogrammed Macrophages Facilitate Breast Cancer Metastasis via NBR2/TBX1 Axis

Multiwalled Carbon Nanotubes-Reprogrammed Macrophages Facilitate Breast Cancer Metastasis via NBR2/TBX1 Axis

Network pharmacology-based approach to investigate the molecular targets of essential oil obtained from lavender for treating breast cancer

Emerging roles of interactions between ncRNAs and other epigenetic modifications in breast cancer

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