Human Adenovirus Type 52: a Type 41 in Disguise?

Jong, J.C. de; Osterhaus, Albert D. M. E.

doi:10.1128/jvi.02457-07

Cited by 20 publications

(13 citation statements)

References 5 publications

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“…Human adenoviruses, members of the family Adenoviridae, are nonenveloped, double-stranded DNA viruses with over 50 known serotypes divided into at least six subgroups (85,86). Adenoviruses are most commonly associated with respiratory illness in humans, ranging from mild to acute respiratory disease, but are capable of causing a diverse range of clinical symptoms depending on the serotype, including gastroenteritis and ocular disease, with or without respiratory involvement (6).…”

Section: Adenovirusesmentioning

confidence: 99%

Ocular Tropism of Respiratory Viruses

Belser

Rota

Tumpey

2013

Microbiol Mol Biol Rev

323

359

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SUMMARY Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus, coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from mild influenza-like symptoms to acute respiratory failure. While species D adenoviruses and subtype H7 influenza viruses are known to possess an ocular tropism, documented human ocular disease has been reported following infection with all principal respiratory viruses. In this review, we describe the anatomical proximity and cellular receptor distribution between ocular and respiratory tissues. All major respiratory viruses and their association with human ocular disease are discussed. Research utilizing in vitro and in vivo models to study the ability of respiratory viruses to use the eye as a portal of entry as well as a primary site of virus replication is highlighted. Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism.

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Section: Adenovirusesmentioning

confidence: 99%

Ocular Tropism of Respiratory Viruses

Belser

Rota

Tumpey

2013

Microbiol Mol Biol Rev

323

359

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“…To date, the functions of the 29.4K and 30.7K proteins are undetermined. Finally, given that HAdV‐G52 was cultured from the stool of a patient with gastroenteritis, this new HAdV species deserves future attention .…”

Section: E3‐19k and Other E3 Proteinsmentioning

confidence: 99%

Immune evasion by adenoviruses: a window into host–virus adaptation

Oliveira

Bouvier

2019

FEBS Letters

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Human adenoviruses (HAdVs) are widespread pathogens that cause a number of partially overlapping, species-specific infections associated with respiratory, urinary, gastrointestinal, and ocular diseases. The early 3 (E3) region of adenoviruses is highly divergent between different species, and it encodes a multitude of proteins with immunomodulatory functions. The study of genetic diversity in the E3 region offers a unique opportunity to gain insight into how the various HAdVs have evolutionarily adapted in response to the selection pressures exerted by host immune defenses. The objective of this review was to discuss subversion of host antiviral immune responses by HAdVs, with a focus on suppression of MHC class I antigen presentation, as a window into host-HAdV adaptation.

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“…A novel human adenovirus, HAdV-52, was identified recently, but whether it should be considered a novel "serotype" remains disputed (6,12). Most HAdV can cause respiratory disease, gastroenteritis, pneumonia, and keratoconjunctivitis, among other diseases (3,10,13).…”

mentioning

confidence: 99%

Serotype-Specific Neutralizing Antibody Epitopes of Human Adenovirus Type 3 (HAdV-3) and HAdV-7 Reside in Multiple Hexon Hypervariable Regions

Qiu

Tian

et al. 2012

J Virol

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bHuman adenovirus types 3 and 7 (HAdV-3 and HAdV-7) occur epidemically and contribute greatly to respiratory diseases, but there is no currently available licensed recombinant HAdV-3/HAdV-7 bivalent vaccine. Identification of serotype-specific neutralizing antibody (NAb) epitopes for HAdV-3 and HAdV-7 will be beneficial for development of recombinant HAdV-3/HAdV-7 bivalent vaccines. In this study, four NAb epitopes within hexon hypervariable regions (HVRs) were predicted for HAdV-3 and HAdV-7, respectively, by using bioinformatics. Eight hexon chimeric adenovirus vectors with the alternation of only one predicted neutralizing epitope were constructed. Further in vitro and in vivo neutralization assays indicated that E2 (residing in HVR2) and E3 (residing in HVR5) are NAb epitopes for HAdV-7, and E3 plays a more important role in generating NAb responses. Cross-neutralization assays indicated that all four predicted epitopes, R1 to R4, are NAb epitopes for HAdV-3, and R1 (residing in HVR1) plays the most important role in generating NAb responses. Humoral immune responses elicited by the recombinant rAdH7R1 (containing the R1 epitope) were significantly and durably suppressed by HAdV-3-specific NAbs. Surprisingly, the rAd⌬E3GFP-specific neutralizing epitope responses induced by rAdMHE3 (R3 replaced by E3) and rAdMHE4 (R4 replaced by E4) were weaker than those of rAdMHE1 (R1 replaced by E1) or rAdMHE2 (R2 relaced by E2) in vitro and in vivo. Furthermore, rAdMHE4 replicated more slowly in HEp-2 cells, and the final yield was about 10-fold lower than that of rAd⌬E3GFP. The current findings contribute not only to the development of new adenovirus vaccine candidates, but also to the construction of new gene delivery vectors.

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Human Adenovirus Type 52: a Type 41 in Disguise?

Cited by 20 publications

References 5 publications

Ocular Tropism of Respiratory Viruses

Ocular Tropism of Respiratory Viruses

Immune evasion by adenoviruses: a window into host–virus adaptation

Serotype-Specific Neutralizing Antibody Epitopes of Human Adenovirus Type 3 (HAdV-3) and HAdV-7 Reside in Multiple Hexon Hypervariable Regions

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