2021
DOI: 10.1016/j.heliyon.2021.e07845
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Human adrenomedullin and its binding protein attenuate tissue injury and inflammation following hepatic ischemia reperfusion in rabbits

Abstract: Background Liver injury caused by ischemia reperfusion (I/R) during surgical procedures, such as liver resection or liver transplantation, is a major cause of liver damage and graft failure. The current method of treatment is mostly preventative (i.e., ischemic preconditioning). While a number of pharmacological modalities have been studied to reduce hepatic I/R injury, none have been entirely successful. It has been demonstrated that the administration of adrenomedullin (AM) in combination with A… Show more

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Cited by 3 publications
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“… 24 , 25 Adrenomedullin is a vasodilator that stimulates increased choroidal blood flow in humans, 26 , 27 and CFH (also known as adrenomedullin-binding protein) may play a role in potentiating this effect. 28 Variability in the CFH gene might also be expected to influence the effect of adrenomedullin on choroidal circulation and thickness. Similarly, the VIPR2 protein is a receptor for vasoactive intestinal peptide, a potent vasodilator, and variability in the VIPR2 gene sequence may modulate CT. 29 , 30 …”
Section: Discussionmentioning
confidence: 99%
“… 24 , 25 Adrenomedullin is a vasodilator that stimulates increased choroidal blood flow in humans, 26 , 27 and CFH (also known as adrenomedullin-binding protein) may play a role in potentiating this effect. 28 Variability in the CFH gene might also be expected to influence the effect of adrenomedullin on choroidal circulation and thickness. Similarly, the VIPR2 protein is a receptor for vasoactive intestinal peptide, a potent vasodilator, and variability in the VIPR2 gene sequence may modulate CT. 29 , 30 …”
Section: Discussionmentioning
confidence: 99%