Human African trypanosomiasis caused by Trypanosoma brucei gambiense: The first case report in China

Nian, Chen; Jin, Ke; Xu, Jingjing; Zhang, Jianfu; Weng, Yali

doi:10.1016/j.ijid.2018.11.004

Cited by 8 publications

(6 citation statements)

References 7 publications

(10 reference statements)

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“…West and Central Africa are endemic areas and the major agent of HAT in this region is T. b. gambiense . 10 Trypanosomiasis caused by T. b. gambiense is a chronic disease with progression to a final central nervous system stage that occurs over months or even years. 10 Several cases of infection were reported in people living in Gabon 11 – 13 and HAT remains a public health problem.…”

Section: Discussionmentioning

confidence: 99%

“…10 Trypanosomiasis caused by T. b. gambiense is a chronic disease with progression to a final central nervous system stage that occurs over months or even years. 10 Several cases of infection were reported in people living in Gabon 11–13 and HAT remains a public health problem. Recent result shows that Komo-Mondah, Noya, and Komo are also active foci.…”

Section: Discussionmentioning

confidence: 99%

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Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

Iroungou

Boundenga

Mangouka

et al. 2020

SAGE Open Medical Case Reports

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Human African Trypanosomiasis (HAT) is an infectious disease due to a protozoa parasite of the Trypanosoma genus. In West and Central Africa, this disease is caused by the subspecies Trypanosoma brucei gambiense. Several foci of this disease are currently active and causing the death of hundreds of people in endemic areas. In this article, we report two cases of gambiense HAT in one Indonesian and one Gabonese men in two historical foci of Gabon in 2019. Both patients had fever with temperatures above 38°C, an altered state of consciousness, cachexia, and multiple dermabrasions on the abdomen related to scratching lesions. The diagnostic revealed second-stage infection of both patients with T. b. gambiense; this result was confirmed by a polymerase chain reaction assay. Despite treatment with a combination of eflornithine and nifurtimox, as recommended by the World Health Organization for late-stage T. b. gambiense HAT, one of the two patients died. Thus, these cases highlight the importance of early HAT diagnosis and prompt patient care to fight effectively against this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

Iroungou

Boundenga

Mangouka

et al. 2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

show abstract

“…mNGS testing of the BALF and blood samples was performed and analysed by BGI-Shenzhen as previously reported [17][18][19]. BALF and blood samples were obtained on the same day and immediately used for the mNGS detection.…”

Section: Metagenomic Next-generation Sequencingmentioning

confidence: 99%

The clinical significance of simultaneous detection of pathogens from bronchoalveolar lavage fluid and blood samples by metagenomic next-generation sequencing in patients with severe pneumonia

Chen

Zhao

Shang

et al. 2021

Journal of Medical Microbiology

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Introduction. Bloodstream infection is a common complication in patients with severe pneumonia and is regarded as an independent risk factor for prediction of poor outcome. Metagenomic next-generation sequencing (mNGS) has been widely applied for pathogen determination of various clinical specimens from patients with infectious diseases. However, the clinical significance of and necessity for simultaneous pathogen detection of both blood samples and bronchoalveolar lavage fluid (BALF) by mNGS in patients with severe pneumonia remains unclear. Hypothesis/Gap Statement. Simultaneous detection of pathogens from both BALF and blood samples in patients with severe pneumonia helps to determine the complication of the bloodstream infection. Aims. This study aimed to elucidate the clinical significance and necessity of pathogen detection simultaneously in both blood samples and BALF samples with the application of mNGS in patients with severe pneumonia. Methods. In this study, 20 patients with severe pneumonia were enrolled and the potential pathogens in both BALF and blood samples were detected simultaneously by conventional microbial examination and mNGS tests. Moreover, multiple consecutive microbial detections were undertaken to investigate the dynamic variation of pathogens during the course of disease progression in two of the 20 patients. Results. In 85 % (17/20) of the patients with severe pneumonia, various pathogens were determined positively in the BALF by mNGS, including 10 cases with bacterial infection, five cases with viral infection and two cases with fungal infection. By contrast, pathogens in 50 % (10/20) of cases could be detected positively in the BALF by conventional microbial tests. Among 17 severe pneumonia patients with mNGS-positive BALF, pathogens were also identified in 10 cases with mNGS-positive blood samples. By contrast, only one patient complicated with a bloodstream infection could be found by conventional bacterial culture. Moreover, the pathogens from BALF were highly consistent with that from blood samples detected by mNGS in the early stage of the disease. With disease progression and after recurrent antibiotic treatment, significant dynamic changes of the microbial species from the BALF and blood samples could be clearly found by mNGS. Conclusions. This study emphasizes the utility of mNGS in the rapid simultaneous detection of pathogens from both BALF and blood samples in patients with severe pneumonia, and could allow determination of bloodstream infection and guide clinicians regarding antimicrobial treatments.

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“…In August 2017, Fujian Provincial Center for Disease Control reported an imported case of African trypanosomiasis (Chen et al, 2019). Subsequently, NIPD led a team from the World Health Organization headquarters and the Fujian Center for Disease Control to review the case and conduct additional testing.…”

Section: Case Study V: Imported Africa Human Trypanosomiasismentioning

confidence: 99%

Construction and application of surveillance and response systems for parasitic diseases in China, led by NIPD-CTDR

Hao

Wang

Cao

et al. 2020

Advances in Parasitology

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Parasitic diseases have been widely epidemic in China with a long history. Great endeavours made in past 70 years led to significant decrease in morbidity and mortablity caused by several major parasitic diseases, while challenges existed to eliminate parasitic diseases. Surveillance-response system has play a crucial role in identifying public health problems, ascertaining the distribution and epidemic dynamics, discovering outbreaks and epidemic anomalies, evaluating the effects of on-site intervention activities and identifying risk factors. In this article, we reviewed the progress of the surveillance system for parasitic diseases, analysed the role of NIPD in the construction and application of surveillance-response system of parasitic diseases through elaborating the surveillance activities and typical surveillance-response events led by NIPD. Suggestion and comments for improve the surveillance-response system were put forward for further control or elimination of parasitic diseases.

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Human African trypanosomiasis caused by Trypanosoma brucei gambiense: The first case report in China

Cited by 8 publications

References 7 publications

Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

Human African trypanosomiasis in two historical foci of the estuaire province, gabon: A case report

The clinical significance of simultaneous detection of pathogens from bronchoalveolar lavage fluid and blood samples by metagenomic next-generation sequencing in patients with severe pneumonia

Construction and application of surveillance and response systems for parasitic diseases in China, led by NIPD-CTDR

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