Human Amniotic Epithelial Cells Produce Dopamine and Survive after Implantation into the Striatum of a Rat Model of Parkinson's Disease: A Potential Source of Donor for Transplantation Therapy

Kakishita, Koji; Elwan, Mohamed A.; Nakao, Naoyuki; Itakura, Toru; Sakuragawa, Norio

doi:10.1006/exnr.2000.7449

Cited by 152 publications

(99 citation statements)

References 24 publications

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“…Very similar findings have also been reported for AECs that confer neuroprotection and functional recovery in animal models of Parkinson's disease (Bankiewicz et al 1994;Kakishita et al 2000Kakishita et al , 2003Kong et al 2008) and ischaemia (Liu et al 2008). The observed therapeutic effects are probably mediated by secretion of diffusible factors, including neurotransmitters (Elwan & Sakuragawa 1997;Sakuragawa et al 1997Sakuragawa et al , 2001) and neurotrophic and growth factors (Koizumi et al 2000;Uchida et al 2000).…”

Section: Brainsupporting

confidence: 77%

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Abdulrazzak

Moschidou

Jones

et al. 2010

J. R. Soc. Interface.

130

118

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Foetal stem cells (FSCs) can be isolated during gestation from many different tissues such as blood, liver and bone marrow as well as from a variety of extraembryonic tissues such as amniotic fluid and placenta. Strong evidence suggests that these cells differ on many biological aspects such as growth kinetics, morphology, immunophenotype, differentiation potential and engraftment capacity in vivo. Despite these differences, FSCs appear to be more primitive and have greater multi-potentiality than their adult counterparts. For example, foetal blood haemopoietic stem cells proliferate more rapidly than those found in cord blood or adult bone marrow. These features have led to FSCs being investigated for pre-and post-natal cell therapy and regenerative medicine applications. The cells have been used in pre-clinical studies to treat a wide range of diseases such as skeletal dysplasia, diaphragmatic hernia and respiratory failure, white matter damage, renal pathologies as well as cancers. Their intermediate state between adult and embryonic stem cells also makes them an ideal candidate for reprogramming to the pluripotent status.

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Section: Brainsupporting

confidence: 77%

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Abdulrazzak

Moschidou

Jones

et al. 2010

J. R. Soc. Interface.

130

118

View full text Add to dashboard Cite

show abstract

“…Our previous study showed that some EGFP-labeled HAECs survive and migrate out of the injection site following transplantation [16]. In addition, HAEC transplantation has been shown to ameliorate impaired functions in a dopamine-degenerated mouse model [26].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1ΔE9-deleted genes

Xue

Chen

Dong

et al. 2012

Sci. China Life Sci.

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Human amniotic epithelial cells (HAECs), which exhibit characteristics of embryonic and pluripotent stem cells, could be utilized for cell therapy without legal or ethical problems. Double-transgenic (TG) mice (n=20) and wild-type (WT) mice (n=20) were randomly assigned to two groups, respectively. The transplantation group was treated with HAECs and the control group with PBS. A six-radial arm water maze was used to assess spatial memory. Immunofluorescence was utilized to track HAEC survival. Immunohistochemistry was used to determine octamer-binding protein 4 (oct-4) and nanog expression in the HAECs. High-performance liquid chromatography (HPLC) was used to measure acetylcholine levels in the hippocampus. The density of cholinergic neurons in the basal forebrain and nerve fibers in the hippocampus was measured following acetylcholinesterase staining. Results showed that transplanted HAECs survived for at least eight weeks and migrated to the third ventricle without immune rejection. Graft HAECs also expressed the specific stem cell markers oct-4 and nanog. Compared with the control group, HAEC transplantation significantly ameliorated spatial memory deficits in TG mice, as well as increased acetylcholine levels and the number of hippocampal cholinergic neurites. Intracerebroventricular HAEC transplantation improved spatial memory in double-TG mice, and results suggested that increased acetylcholine levels in the hippocampus, released by surviving cholinergic neurites, were responsible for this improvement.Alzheimer's disease, human amniotic epithelial cells, spatial memory deficit, transgenic mice Citation:Xue S R, Chen C F, Dong W L, et al. Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1E9-deleted genes.

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“…acetylcholine and catecholamine synthesis and release) to their ability to sustain the early phases of neuroepithelium formation and neural development of the embryo [17]. In addition these cells can survive after implantation into a rat model of Parkinson's disease [18] or after spinal cord injury [19] and differentiate into neuron-like cells after transplantation [9]. Only a recent article by Prusa et al reports neuronal differentiation of AFCs after exposition to a medium containing 2% serum and 1.25% dimethyl sulfoxide (DMSO) [20].…”

Section: Discussionmentioning

confidence: 99%

Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential

et al. 2006

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Human Amniotic Epithelial Cells Produce Dopamine and Survive after Implantation into the Striatum of a Rat Model of Parkinson's Disease: A Potential Source of Donor for Transplantation Therapy

Cited by 152 publications

References 24 publications

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Biological characteristics of stem cells from foetal, cord blood and extraembryonic tissues

Therapeutic effects of human amniotic epithelial cell transplantation on double-transgenic mice co-expressing APPswe and PS1ΔE9-deleted genes

Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential

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