2018
DOI: 10.2147/ijn.s150897
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Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments

Abstract: Objective It is a great challenge to absorb and conduct biophysicochemical interactions at the nano-bio interface. Peptides are emerging as versatile materials whose function can be programmed to perform specific tasks. Peptides combined nanoparticles might be utilized as a new approach of treatment. Human β-defensin 3 (hBD3), possesses both antimicrobial and proregeneration properties. Gold nanoparticles (AuNPs) have shown promising applications in the field of tissue engineering. However, the co… Show more

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Cited by 45 publications
(29 citation statements)
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“…HBD2 and HBD3 can induce osteoblast-like cells MG63 to differentiate into osteoblasts, increase the expression level of osteoblast markers and promote mineralization (Kraus et al, 2012). The combination of HBD3 and gold nanoparticles can promote the differentiation of human periodontal ligament stem cells into osteoblasts under inflammation (Zhou J. et al, 2018). However, the differentiation induction ability of HBD4 on SHED have not yet been reported.…”
Section: Discussionmentioning
confidence: 99%
“…HBD2 and HBD3 can induce osteoblast-like cells MG63 to differentiate into osteoblasts, increase the expression level of osteoblast markers and promote mineralization (Kraus et al, 2012). The combination of HBD3 and gold nanoparticles can promote the differentiation of human periodontal ligament stem cells into osteoblasts under inflammation (Zhou J. et al, 2018). However, the differentiation induction ability of HBD4 on SHED have not yet been reported.…”
Section: Discussionmentioning
confidence: 99%
“…The resulting synthetic extracellular matrix biology can be printed into tubular structures that support cell proliferation and matrix remodeling. In addition to the pre-osteoblasts mentioned above, the osteogenic differentiation of human periodontal cells (hPDLCs) was also significantly enhanced by GNPs modified by human β-defensin 3 (hBD3), and by activating the Wnt / β-catenin signaling pathway in the inflammatory microenvironment [101]. GNPs in injectable calcium phosphate cement (CPC) enhance osteogenic differentiation of human dental pulp stem cells,including better wetting, greater protein adsorption, and improved cell attachment and spreading [102].…”
Section: Composite Natural Polymermentioning
confidence: 99%
“…Human β-defensin 3 (hBD3), a small molecule cationic antimicrobial peptide consisting of 45 amino acids, is perceived to be the most promising antimicrobial peptide ( Harder et al, 2001 ; Dhople et al, 2006 ). Former studies have demonstrated that hBD3 is perceived to be the most promising antimicrobial peptide and can potentially promote the osteogenic differentiation of human periodontal ligament cells (hPDLCs) in inflammatory microenvironments ( Zhou et al, 2018 ). However, recombinant hBD3 is extremely expensive and difficult to store.…”
Section: Introductionmentioning
confidence: 99%