Human asthma phenotypes: from the clinic, to cytokines, and back again

Bhakta, Nirav R.; Woodruff, Prescott G.

doi:10.1111/j.1600-065x.2011.01032.x

Cited by 171 publications

(142 citation statements)

References 134 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…The fact that not only eosinophils, but also neutrophils (synonymous to neutrophilic granulocytes or polymorphonuclear granulocytes), are mobilised in certain clinical phenotypes of asthma has been recognised [2][3][4][5][6]. This is also true for the fact that clinically important phenotypes among adult patients lack signs of true allergy.…”

Section: Introductionmentioning

confidence: 90%

Interleukin-17 cytokine signalling in patients with asthma

Lindén

Dahlén

2014

Eur Respir J

View full text Add to dashboard Cite

Asthma remains a global health problem and, therefore, more effective pharmacotherapy is needed. This is particularly true for chronic and severe asthma. In these clinical phenotypes, chronic inflammation involving neutrophils is likely to play a pathogenic role, making it interesting to target cytokine signalling involved in the accumulation of neutrophils. Therefore, it is of interest that the archetype T-helper 17 cell cytokine interleukin (IL)-17A, perhaps also IL-17F, controls neutrophil accumulation, mucus secretion, macrophage mobilisation and smooth muscle reactivity in various experimental airway models. However, much less is known about the involvement of signalling via IL-17 cytokines in humans with asthma. Existing evidence suggests that these cytokines are released from several types of immune cells in asthma and, for IL-17A, there is a local increase associated with disease severity, with the mobilisation of neutrophils and smooth muscle cells locally in the airways. Even though the causative role of IL-17 cytokines remains unclear, there is potential for clinical utility in targeting IL-17A specifically in patients with moderate-to-severe asthma and high reversibility. There is a need for new and well-powered clinical investigations of signalling via IL-17 cytokines in this clinical phenotype. @ERSpublications There is potential utility for drugs targeting IL-17 cytokine signalling in a sub-group of patients with asthma

show abstract

Section: Introductionmentioning

confidence: 90%

Interleukin-17 cytokine signalling in patients with asthma

Lindén

Dahlén

2014

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…This set of three genes was induced in a subset of our subjects with asthma, and those subjects had increased expression of IL-13 and IL-4 by quantitative PCR in accompanying bronchial biopsies, and increased eosinophilia in bronchoalveolar lavage fluid. Therefore, we considered these three genes to be markers of a "Th2-high" endotype of asthma (14,28), which is highly overlapping with "eosinophilic asthma" as described by cytological analyses of sputum.…”

Section: Airway Epithelial Mrnas As Endotypic Markersmentioning

confidence: 99%

“…Although mouse models of asthma have allowed significant progress in understanding the molecular and cellular underpinnings of allergic airway disease, human asthma is a clinically heterogeneous disease (13,14), and this clinical heterogeneity may reflect differences in underlying biology and point to specific endotypes (14,15). Specifically, the Th2-driven pathways observed in these murine models of asthma reflect the molecular events occurring in only a subset of patients with asthma.…”

mentioning

confidence: 99%

Subtypes of Asthma Defined by Epithelial Cell Expression of Messenger RNA and MicroRNA

Woodruff

2013

Annals ATS

View full text Add to dashboard Cite

Human asthma can be subcategorized in several ways, but one powerful approach is to subtype asthma on the basis of underlying cellular and molecular mechanisms. Groups of patients with a disease that share a common underlying biology are termed an "endotype." Endotypes of asthma have been studied at both the cellular level (by cytological examination of induced sputum) and, increasingly, at the molecular level. Genome-wide analyses of mRNA expression within the lung have been useful in the identification of molecular endotypes of asthma and point to protein biomarkers of those endotypes that can be measured in the blood. More recently, studies of microRNA expression in airway epithelial cells in asthma have identified additional candidate biomarkers of asthma endotypes. One potentially valuable property of microRNAs is that they can also be measured in extracellular fluids and therefore have the potential to serve directly as noninvasively measured biomarkers.

show abstract

“…Asthma is a chronic lung airway inflammation characterised by a Th-2 response with a robust production of IL-4, IL-5 and IL-13, which initiate and perpetuate the disease status (17) . Elevated IgE responses, mast cell degranulation and eosinophilic inflammation are the consequences of the above-cited abnormal Th-2 responses (17,18) . Over recent years, the role of T-regulatory (Treg) cells in asthma has been investigated since they are able to inhibit both Th-1 and Th-2 responses (19) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Influence of polyphenols on allergic immune reactions: mechanisms of action

Magrone

Jirillo

2012

Proc. Nutr. Soc.

View full text Add to dashboard Cite

The increased incidence of allergic disease seems to rely on many factors. Among them, the association between genetic variations of the immune response and environmental pressure by allergens, infectious agents and pollutants should be taken into consideration. In alternative to conventional treatments with corticosteroids and antihistaminics, nutraceuticals have been shown to act on allergic disease either during allergic sensitisation or on consolidated disease. In this review, special emphasis is placed on the effects of dietary polyphenols on three major allergic diseases, namely atopic eczema, food allergy and asthma. Interference of polyphenols with T-helper 2 activation seems to be the main mechanism of their inhibitory effects on allergy development. Moreover, deficits of T-regulatory cells seem to play a pathogenic role in allergic disease and, therefore, these cells may represent a major target of polyphenol activity

show abstract

Human asthma phenotypes: from the clinic, to cytokines, and back again

Cited by 171 publications

References 134 publications

Interleukin-17 cytokine signalling in patients with asthma

Interleukin-17 cytokine signalling in patients with asthma

Subtypes of Asthma Defined by Epithelial Cell Expression of Messenger RNA and MicroRNA

Influence of polyphenols on allergic immune reactions: mechanisms of action

Contact Info

Product

Resources

About