Human biomonitoring in the Czech Republic: An overview

Černá, Milena; Krsková, Andrea; Čejchanová, Mája; Spěváĉková, Věra

doi:10.1016/j.ijheh.2011.09.007

Cited by 131 publications

(48 citation statements)

References 30 publications

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“…In addition to NHANES, several large biomonitoring programs have been conducted in European and North American countries over the last decade (Cerna et al, 2012; Den Hond et al, 2015; Fréry et al, 2012; Haines and Murray, 2012; Kolossa-Gehring et al, 2012; Mørck et al, 2015b; Perez-Gomez et al, 2013; Schoeters et al, 2012). Large-scale birth cohorts are also increasingly publishing biomonitoring results from their study populations (Guxens et al, 2012; Kawamoto et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…These included metals, persistent chemicals, such as organochlorines, and non-persistent chemicals, such as phthalates, phytoestrogens and pesticides. We compared their concentrations with those of U.S. women of child-bearing age who participated in NHANES 2005–2012 and with other international biomonitoring studies (Cerna et al, 2012; Den Hond et al, 2015; Fréry et al, 2012; Haines and Murray, 2012; Kolossa-Gehring et al, 2012; Mørck et al, 2015b; Perez-Gomez et al, 2013; Schoeters et al, 2012). We used PCA to quantify the correlation of biomarkers between and within chemical classes.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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Background Current exposure assessment research does not sufficiently address multi-pollutant exposure and their correlations in human media. Understanding the extent of chemical exposure in reproductive-aged women is of particular concern due to the potential for in utero exposure and fetal susceptibility. Objectives The objectives of this study were to characterize concentrations of chemical biomarkers during preconception and examine correlations between and within chemical classes. Methods We examined concentrations of 135 biomarkers from 16 chemical classes in blood and urine from 73 women aged 18–40 enrolled in Snart Foraeldre/Milieu, a prospective cohort study of pregnancy planners in Denmark (2011–2014). We compared biomarker concentrations with United States similarly-aged, non-pregnant women who participated in the National Health and Nutrition Environmental Survey (NHANES) and with other international biomonitoring studies. We performed principal component analysis to examine biomarker correlations. Results The mean number of biomarkers detected in the population was 92 (range: 60–108). The most commonly detected chemical classes were phthalates, metals, phytoestrogens and polycyclic aromatic hydrocarbons. Except blood mercury, urinary barium and enterolactone, geometric means were higher in women from NHANES. Chemical classes measured in urine generally did not load on a single component, suggesting high between-class correlation among urinary biomarkers, while there is high within-class correlation for biomarkers measured in serum and blood. Conclusions We identified ubiquitous exposure to multiple chemical classes in reproductive-aged Danish women, supporting the need for more research on chemical mixtures during preconception and early pregnancy. Inter- and intra-class correlation between measured biomarkers may reflect common exposure sources, specific lifestyle factors or shared metabolism pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Rosofsky

Janulewicz

Thayer

et al. 2017

Environmental Research

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“…Experience with human biomonitoring in the general population differs among European countries, with long-standing traditions in countries such as Germany (Becker et al 2008), France (Fréry et al 2012), the Czech Republic (Cerná et al 2012), Belgium (Flanders) (Schoeters et al 2012), and Spain (Pérez-Gómez 2013), whereas other countries have no experience at all.…”

Section: Introductionmentioning

confidence: 99%

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

Hond

Govarts

Willems

et al. 2015

Environ Health Perspect

171

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BackgroundFor Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.ObjectivesWe developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.MethodsIn 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5–11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011–2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.ResultsBiomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.ConclusionsWe have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.CitationDen Hond E, Govarts E, Willems H, Smolders R, Casteleyn L, Kolossa-Gehring M, Schwedler G, Seiwert M, Fiddicke U, Castaño A, Esteban M, Angerer J, Koch HM, Schindler BK, Sepai O, Exley K, Bloemen L, Horvat M, Knudsen LE, Joas A, Joas R, Biot P, Aerts D, Koppen G, Katsonouri A, Hadjipanayis A, Krskova A, Maly M, Mørck TA, Rudnai P, Kozepesy S, Mulcahy M, Mannion R, Gutleb AC, Fischer ME, Ligocka D, Jakubowski M, Reis MF, Namorado S, Gurzau AE, Lupsa IR, Halzlova K, Jajcaj M, Mazej D, Snoj Tratnik J, López A, Lopez E, Berglund M, Larsson K, Lehmann A, Crettaz P, Schoeters G. 2015. First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale. Environ Health Perspect 123:255–263; http://dx.doi.org/10.1289/ehp.1408616

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“…These programmes have established reference values, tracked trends of chemical exposures over time and determined regional differences in contaminant levels. The results from these studies can be used to inform policy needs, to evaluate effectiveness of policy measures and to determine whether environmental exposures lead to biological effects (Becker et al 2007; Centers for Disease Control and Prevention 2014; Černá et al 2012;Schoeters et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK

Exley

Aerts

Biot

et al. 2015

Environ Sci Pollut Res

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Exposure to a number of environmental chemicals in UK mothers and children has been assessed as part of the European biomonitoring pilot study, Demonstration of a Study to Coordinate and Perform Human Biomonitoring on a European Scale (DEMOCOPHES). For the Europeanfunded project, 17 countries tested the biomonitoring guidelines and protocols developed by COPHES. The results from the pilot study in the UK are presented; 21 school children aged 6-11 years old and their mothers provided hair samples to measure mercury and urine samples, to measure cadmium, cotinine and several phthalate metabolites: mono(2-ethyl-5-hydroxyhexyl)phthalate (5OH-MEHP), mono(2-ethyl-5-oxoh e x y l ) p h t h a l a t e ( 5 o x o -M E H P ) a n d m o n o ( 2 -ethylhexyl)phthalate (MEHP), mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-benzyl phthalate (MBzP) and mono-n-butyl phthalate (MnBP). Questionnaire data was collected on environment, health and lifestyle. Mercury in hair was higher in children who reported frequent consumption of fish (geometric mean 0.35 μg/g) compared to those that ate fish less frequently (0.13 μg/g, p=0.002).Cadmium accumulates with age as demonstrated by higher levels of urinary cadmium in the mothers (geometric mean 0.24 μg/L) than in the children(0.14 μg/L). None of the mothers reported being regular smokers, and this was evident with extremely low levels of cotinine measured (maximum value 3.6 μg/L in mothers, 2.4 μg/L in children). Very low levels of the phthalate metabolites were also measured in both mothers and children (geometric means in mothers: 5OH-Responsible editor:

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Human biomonitoring in the Czech Republic: An overview

Cited by 131 publications

References 30 publications

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

Exposure to multiple chemicals in a cohort of reproductive-aged Danish women

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

Pilot study testing a European human biomonitoring framework for biomarkers of chemical exposure in children and their mothers: experiences in the UK

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