Human biomonitoring of per- and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019

Göckener, Bernd; Weber, Till; Rüdel, Heinz; Bücking, Mark; Kolossa-Gehring, Marike

doi:10.1016/j.envint.2020.106123

Cited by 135 publications

(65 citation statements)

References 80 publications

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“…2019 ). Because measures of some legacy PFAS in the general population are declining over time ( Göckener et al. 2020 ; Seo et al.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, PFAS are ubiquitous in the environment and are commonly detected in humans, both in the United States ( Calafat et al. 2019 ) and globally ( Göckener et al. 2020 ; Seo et al.…”

Section: Introductionmentioning

confidence: 99%

“…Because the half-lives of some of these chemicals are long, ranging from several days to over a decade (ATSDR 2021), and they do not degrade in the environment (Sunderland et al 2019;Zhang et al 2013), they are sometimes referred to as forever chemicals. As a result, PFAS are ubiquitous in the environment and are commonly detected in humans, both in the United States (Calafat et al 2019) and globally (Göckener et al 2020;Seo et al 2018;Timmermann et al 2020). Although some long-chain PFAS are being phased out of production (and also known as legacy PFAS), the use of other novel PFAS is increasing (ITRC 2020a).…”

Section: Introductionmentioning

confidence: 99%

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Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk

Bommarito

Ferguson

Meeker

et al. 2021

Environ Health Perspect

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Background: Prenatal exposure to perfluoroalkyl substances (PFAS) has been previously associated with preeclampsia, although findings are mixed with respect to the direction and magnitude of effect. To our knowledge, no studies have examined associations between PFAS and preeclampsia subtypes, which may have distinct etiologies. Objective: We examined associations between PFAS, any preeclampsia diagnosis, and early- and late-onset preeclampsia. In addition, we estimated associations between PFAS and the angiogenic biomarkers soluble fms-like tyrosine kinase-1 (sFLT-1) and placental growth factor (PlGF), which provide an estimate of pro- and anti-angiogenic activity within the placenta. Methods: This case–control study ( cases, controls) was sampled from the LIFECODES birth cohort. Nine legacy PFAS were quantified in maternal plasma from early pregnancy ( 10 wk) and angiogenic biomarkers were quantified in maternal plasma from four study visits ( 10, 18, 26, and 35 wk). Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the association between an interquartile range (IQR)-increase in PFAS and preeclampsia outcomes. Linear regression was used to estimate associations between an IQR-increase in PFAS and concentrations of angiogenic biomarkers. Results: Both perfluorodecanoic acid ( 1.64, 95% CI: 1.08, 2.47) and perfluorooctanesulfonic acid ( 1.60, 95% CI: 1.06, 2.43) were associated with higher odds of late-onset preeclampsia. Associations tended to be below the null for early-onset preeclampsia, although findings were imprecise. Few associations were noted between PFAS and angiogenic biomarkers. Discussion: Maternal PFAS concentrations were associated with higher odds of late-onset preeclampsia. Heterogeneity of preeclampsia should be considered in future studies because populations may have different distributions of disease subtypes. https://doi.org/10.1289/EHP9091

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“…2019 ). Because measures of some legacy PFAS in the general population are declining over time ( Göckener et al. 2020 ; Seo et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk

Bommarito

Ferguson

Meeker

et al. 2021

Environ Health Perspect

View full text Add to dashboard Cite

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“…Studies from Germany report on the analysis of serum samples for HFPO-DA, 6:2 Cl-PFESA, 8:2 Cl-PFESA, DONA, 7H-perfluoroheptanoic acid (7H-PFHpA), perfluoroethylcyclohexanesulfonic acid (PFECHS), fluorotelomer sulfonic acids (FTSs), and fluorotelomer phosphate diesters (diPAPs) [134,135]. Analyses of plasma samples collected between 2009 and 2019 and archived in the German Environmental Specimen Bank produced a 1% detection frequency for 8:2 FTS; however, no other emerging PFAS were detected [134]. In a separate study, Fromme et al analyzed 396 plasma samples collected between 2009 and 2016 from blood donors living in South Germany [135].…”

Section: Human Exposure and Biomonitoringmentioning

confidence: 99%

Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects

Brase

Mullin

Spink

2021

IJMS

181

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Due to their unique chemical properties, per- and polyfluoroalkyl substances (PFAS) have been used extensively as industrial surfactants and processing aids. While several types of PFAS have been voluntarily phased out by their manufacturers, these chemicals continue to be of ecological and public health concern due to their persistence in the environment and their presence in living organisms. Moreover, while the compounds referred to as “legacy” PFAS remain in the environment, alternative compounds have emerged as replacements for their legacy predecessors and are now detected in numerous matrices. In this review, we discuss the historical uses of PFAS, recent advances in analytical techniques for analysis of these compounds, and the fate of PFAS in the environment. In addition, we evaluate current biomonitoring studies of human exposure to legacy and emerging PFAS and examine the associations of PFAS exposure with human health impacts, including cancer- and non-cancer-related outcomes. Special focus is given to short-chain perfluoroalkyl acids (PFAAs) and ether-substituted, polyfluoroalkyl alternatives including hexafluoropropylene oxide dimer acid (HFPO-DA; tradename GenX), 4,8-dioxa-3H-perfluorononanoic acid (DONA), and 6:2 chlorinated polyfluoroethersulfonic acid (6:2 Cl-PFESA; tradename F-53B).

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“…The most frequently detected PFAS in human samples worldwide is PFOS (perfluorooctane sulfonate) and PFOA (perfluorooctanoic acid). For example, in the serum samples of German population from 2019, the concentrations of PFOA and PFOS ranged between 2 and 6 × 10 −9 M and 2–10 × 10 −9 M, respectively ( Göckener et al, 2020 ). In China, median serum concentrations of PFOA (36 10 × 10 −9 M) and PFOS (30 10 × 10 −9 M) were significantly higher ( Duan et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

et al. 2021

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Male fertility has been deteriorating worldwide for considerable time, with the greatest deterioration recorded mainly in the United States, Europe countries, and Australia. That is, especially in countries where an abundance of chemicals called endocrine disruptors has repeatedly been reported, both in the environment and in human matrices. Human exposure to persistent and non-persistent chemicals is ubiquitous and associated with endocrine-disrupting effects. This group of endocrine disrupting chemicals (EDC) can act as agonists or antagonists of hormone receptors and can thus significantly affect a number of physiological processes. It can even negatively affect human reproduction with an impact on the development of gonads and gametogenesis, fertilization, and the subsequent development of embryos. The negative effects of endocrine disruptors on sperm gametogenesis and male fertility in general have been investigated and repeatedly demonstrated in experimental and epidemiological studies. Male reproduction is affected by endocrine disruptors via their effect on testicular development, impact on estrogen and androgen receptors, potential epigenetic effect, production of reactive oxygen species or direct effect on spermatozoa and other cells of testicular tissue. Emerging scientific evidence suggests that the increasing incidence of male infertility is associated with the exposure to persistent and non-persistent endocrine-disrupting chemicals such as bisphenols and perfluoroalkyl chemicals (PFAS). These chemicals may impact men’s fertility through various mechanisms. This study provides an overview of the mechanisms of action common to persistent (PFAS) and nonpersistent (bisphenols) EDC on male fertility.

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Human biomonitoring of per- and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019

Cited by 135 publications

References 80 publications

Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk

Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk

Legacy and Emerging Per- and Polyfluoroalkyl Substances: Analytical Techniques, Environmental Fate, and Health Effects

Overview of the Mechanisms of Action of Selected Bisphenols and Perfluoroalkyl Chemicals on the Male Reproductive Axes

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