Human biomonitoring reference values for metals and trace elements in blood and urine derived from the Canadian Health Measures Survey 2007–2013

“…Human biomonitoring (HBM) allows the assessment of internal exposure to hazardous substances by measuring reaction products in human body fluids based on the matrix. According to many studies, [9][10][11] the most important biomonitoring matrices are blood, serum, plasma, or urine, necessary for the analysis and for the limit of detection (LOD) of the analytical technique. Sometimes, establishing a correlation between biomonitoring data in saliva and established biomonitoring matrices of blood is possible.…”

Section: Saliva Biomonitoring: the Great Challenge For A Neglected mentioning

confidence: 99%

Suggestions for creating the International Scientific Foundation of Saliva Diagnosis (ISFSD): New research strategies, development, and technologies

Mediouni¹,

Kaczor‐Urbanowicz

Madiouni

2019

Oral Science International

View full text Add to dashboard Cite

Saliva is an emerging biofluid for personalized/precision medicine application. As it has recently become a major tool for biological research and biomarker discovery, it is of vital importance to develop and optimize the diagnostics standards to decipher the omics constituents in saliva in order to achieve better oral and systemic health. Although current variations in saliva sampling, study designs, and developmental methods of salivary biomarkers prevent direct comparisons of the data obtained from different studies, the lack of standardization and unification of the processing procedures undermines saliva's diagnostic potential. Thus, it motivated us to propose the idea of creating an International Scientific Foundation of Salivary Diagnosis (ISFSD) that could encourage collaborative efforts to establish international guidelines and standardized protocols for saliva collection and laboratorial processing as well as clinical diagnostics. The ISFSD can accelerate the validation of biomarkers in larger groups of patients, their regulatory approval, and implementation of saliva diagnostics into a real clinical practice. It will also result in identification of practical and achievable priorities, and will present policy initiatives critical to the implementation of oral health improvement programs. The establishment of ISFSD will be of great interest and influence in the fields of oral health, dentistry, and medicine.

show abstract

“…The Canadian Health Measures Survey (CHMS), 20 in accordance with the latest German Environmental Survey (GerES IV), 27 obtained a [1.8-3.0] Brazil, (23) 18-74 175 men 6.11 µg/g of creat.…”

Section: Urinary Mercurymentioning

confidence: 99%

Pediatric reference values for chromium and mercury in urine in the City of Buenos Aires and Greater Buenos Aires

et al. 2019

View full text Add to dashboard Cite

Introduction. Due to the heavy industrialization of the Autonomous City of Buenos Aires and Greater Buenos Aires, the population may have become exposed to metals. To assess the level of exposure to chromium and mercury in children, it is critical to have local reference values (RVs). Our objective was to determine pediatric RVs for chromium and mercury in a single urine sample. Population and methods: Children who were not exposed to the studied contaminants and who attended the Department of Low Risk Conditions and the Daycare Center Office of Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" were included. Urinary chromium (UCr), urinary mercury (UHg), and urinary creatinine were measured. The p95 and its corresponding 95 % confidence interval (CI) were estimated based on the RV concept proposed by the German Human Biomonitoring Commission. Results: The study included 160 patients. A total of 144 samples from children aged 1-17 years (median: 7 years) were collected. UCr was measured in 137 samples and UHg, in 129 samples. The median value of chromium was 0.54 µg/g of creatinine (range, undetectable to 3.06), while that of mercury was 0.49 µg/g of creatinine (range, undetectable to 7.57). Conclusions: The RVs for UCr were up to 1.5 µg/L [1.2-2.8] and up to 2.2 µg/g of creatinine [1.8-3.0], and for UHg, up to 2.5 µg/L [1.8-4.8] and 3.2 µg/g of creatinine [2.5-4.7].

show abstract

Human biomonitoring reference values for metals and trace elements in blood and urine derived from the Canadian Health Measures Survey 2007–2013

Cited by 166 publications

References 43 publications

Valores de referencia pediátricos de cromo y mercurio en orina del área de la Ciudad de Buenos Aires y alrededores

Valores de referencia pediátricos de cromo y mercurio en orina del área de la Ciudad de Buenos Aires y alrededores

Suggestions for creating the International Scientific Foundation of Saliva Diagnosis (ISFSD): New research strategies, development, and technologies

Pediatric reference values for chromium and mercury in urine in the City of Buenos Aires and Greater Buenos Aires

Contact Info

Product

Resources

About