Human bocavirus—the first 5 years

Jartti, Tuomas; Hedman, Klaus; Jartti, Laura; Ruuskanen, Olli; Allander, Tobias; Söderlund‐Venermo, Maria

doi:10.1002/rmv.720

Cited by 245 publications

(307 citation statements)

References 172 publications

(426 reference statements)

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“…HBoV has also been associated with acute respiratory illnesses, predominantly among young children [131–133], and has been suggested as a potential cause of acute respiratory illnesses and recurrent wheezing episodes across several studies of preterm infants and children [134–136]. …”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…1 HBoV1 is increasingly recognized as a cause of respiratory infection worldwide; it has been estimated to be among the four most prevalent viruses along with respiratory syncytial, rhino-and adenoviruses in children hospitalized for respiratory disease. [16][17][18][19][20][21] HBoV1 genomes have also been observed in stool among 0-13% of patients with or without gastroenteritis 22 and in 0-44% of respiratory samples from individuals with non-infectious illnesses. 23,24 Serodiagnosis or HBoV1 DNA detection in serum therefore provides more reliable diagnosis of acute HBoV1 infection.…”

Section: Introductionmentioning

confidence: 99%

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Rahiala

Koskenvuo

Norja

et al. 2013

Bone Marrow Transplant

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Among the immunocompetent, infections with parvovirus B19 (B19V) and human bocavirus (HBoV) 1 range clinically from asymptomatic to severe, while following allogeneic hematopoietic SCT (HSCT) B19V can cause a persistent severe illness. The epidemiology and clinical impact of HBoV1 and the other emerging parvovirus 4 (PARV4) among immunocompromised patients have not been established. To determine the occurrence and clinical spectrum of B19V, PARV4 and HBoV1 infections, we performed a longitudinal molecular surveillance among 53 allogeneic HSCT recipients for pre-and post-HSCT DNAemias of these parvoviruses. Quantitative real-time PCR showed B19V DNA in sera of 16 (30%) patients, at mean levels of 4.6 Â 10 3 , 9.9 Â 10 7 , 1.1 Â 10 10 and 1.6 Â 10 2 B19V DNA copies/mL pre-HSCT (9/53), and at 1 (6/53), 2 (4/53) and 3 months (1/25) post HSCT, respectively. However, no clinical manifestation correlated with the presence of B19V viremia. All B19V sequences were of genotype 1. None of the sera investigated contained PARV4 or HBoV1 DNAs. Our data demonstrate B19V viremia to be frequent among pediatric allogeneic HSCT recipients, yet without apparent clinical correlates. PARV4 or HBoV1 viremias were not seen in these immunocompromised patients.

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“…The second ORF encodes for two major structural proteins (VP1 and VP2) that comprise the viral capsid. The third ORF encodes for a non-structural nuclear phosphoprotein (NP1) (Allander et al 2005, Schildgen et al 2008, Jartti et al 2012.…”

mentioning

confidence: 99%

“…HBoV-2, HBoV-3 and HBoV-4 have mainly been detected in stool samples, with HBoV-2 and possibly HBoV-3 being associated with gastroenteritis , Jartti et al 2012. However, several studies (Campe et al 2008, Arthur et al 2009, Han et al 2009), including those conducted in Brazil (Albuquerque et al 2007, Santos et al 2010, have attempted to detect HBoVs in faecal samples obtained from individuals presenting with acute gastroenteritis.…”

mentioning

confidence: 99%

Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

Sousa¹,

Souza²,

Fiaccadori³

et al. 2012

Mem. Inst. Oswaldo Cruz

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To determine the positivity rate of human bocavirus (HBoV) 1 and 3 among children who presented with acute gastroenteritis symptoms during the period of 1994-2004 in the Central-West Region of Brazil, 762 faecal samples were tested using polymerase chain reaction (PCR) for the detection of HBoV DNA. Primers for a segment of the non-structural viral protein 1 (NS1) gene of HBoV-1 and HBoV-3 were used. Twelve HBoV-positive samples were further characterised via genomic sequencing and phylogenetic analysis. Of the samples tested, 5.8% (n = 44) were positive for HBoV-1 or HBoV-3 and co-infection was observed in 14 (31.8%) of the 44 HBoV-positive samples. Nine of the 14 samples were also positive for Rotavirus A and five were positive for Aichi virus. The genomic sequencing of the NS1 partial sequence of 12 HBoV-samples showed that 11 samples were characterised as HBoV-1 and that one was characterised as HBoV-3. The phylogenetic analysis showed that the HBoV-1 samples had a high sequence homology to others previously identified in China, Sweden and Brazil. This is the first study conducted in the Central-West Region of Brazil to detect HBoV-1 and HBoV-3 in faecal samples from children with acute gastroenteritis. Further studies are required to define the role of HBoVs as aetiological agents of gastroenteritis

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Human bocavirus—the first 5 years

Cited by 245 publications

References 172 publications

The impact of respiratory viruses on lung health after preterm birth

The impact of respiratory viruses on lung health after preterm birth

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Human bocavirus 1 and 3 infection in children with acute gastroenteritis in Brazil

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