The impact of respiratory viruses on lung health after preterm birth

Townsi, Nada; Laing, Ingrid A.; Hall, Graham L.; Simpson, Shannon J.

doi:10.1080/20018525.2018.1487214

Cited by 46 publications

(38 citation statements)

References 138 publications

(159 reference statements)

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“…7 , 18 Early hospitalization with RSV-infection in preterm infants has been associated with more than twice the risk of ongoing respiratory morbidity, especially among those with BPD or lower gestational age. 19 Like RSV, HRV-respiratory infections have also been associated with higher risk of asthma at 6 years. In our series, apart from the family history of asthma or atopy classically described, the factors independently associated with asthma at 6–9 years in children admitted for bronchiolitis, were HRV infection, viral coinfection and prematurity, that will be discussed below.…”

Section: Discussionmentioning

confidence: 99%

<p>Impact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6–9 Years</p>

García-García¹,

González-Carrasco²,

Bracamonte³

et al. 2020

JAA

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Background Premature birth is associated with increased susceptibility for viral infections and chronic airway morbidity. Preterm children, even moderate and late, may be at risk for short- and long-term respiratory morbidities. Objective Our main goal was to compare the burden of two conditions, severe bronchiolitis and prematurity (early and moderate-late), on asthma development at 6–9 years. Patients and Methods A retrospective cohort of all preterm (<37weeks gestational age) and full-term children hospitalized for bronchiolitis, with current age between 6 and 9 years, was created. A second cohort was made up of preterm children, without admission for bronchiolitis, randomly chosen from the hospital premature births database. Prevalence and risk factors for asthma were analysed. Parents completed the International Study of Asthma and Allergies in Childhood (ISAAC) Questionnaire for asthma symptoms for children 6–7 years. Lung function and aeroallergen sensitization were evaluated. Results Of the 480 selected children, 399 could be contacted and agreed to participate: 133 preterm and 114 full-term cases with admission for bronchiolitis and 146 preterm control children without admission for bronchiolitis. The frequency of current asthma at 6–9 years was higher in preterm cases (27%) compared with full-term-cases (15%) and preterm controls (14%) (p=0.04). Among hospitalized-bronchiolitis children, prematurity (p=0.04), rhinovirus infection (p=0.03), viral coinfection (p=0.04) and paternal asthma (p=0.003) were risk factors for asthma at 6–9 years. Among premature children, with and without bronchiolitis admission, the risk factors for asthma at 6–9 years were admission for bronchiolitis (p=0.03) and aeroallergen sensitisation (p=0.01). Moderate and late preterm children without admission for bronchiolitis showed similar prevalence of current asthma than full-term ones, previously admitted for bronchiolitis. Conclusion Preterm birth is an important early life risk factor for asthma in childhood. The addition of other risk factors, such as severe bronchiolitis, especially by rhinovirus or viral coinfections, are associated with even higher risk for subsequent asthma.

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Section: Discussionmentioning

confidence: 99%

<p>Impact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6–9 Years</p>

García-García¹,

González-Carrasco²,

Bracamonte³

et al. 2020

JAA

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“…Acute respiratory infections (ARI) are a leading cause of hospitalizations and death in children <5 years of age throughout the world . Preterm infants, particularly those suffering from bronchopulmonary dysplasia (BPD), are at increased risk of severe ARI and death compared to term infants . Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections in children and the most common etiology of pneumonia in hospitalized infants .…”

Section: Introductionmentioning

confidence: 99%

“…1 Preterm infants, particularly those suffering from bronchopulmonary dysplasia (BPD), are at increased risk of severe ARI and death compared to term infants. 2 Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections in children and the most common etiology of pneumonia in hospitalized infants. [3][4][5] Preterm infants hospitalized with RSV infections are at high risk of requiring admission to the intensive care unit (ICU).…”

Section: Introductionmentioning

confidence: 99%

Respiratory syncytial virus acute respiratory infection‐associated hospitalizations in preterm Mexican infants: A cohort study

Benítez‐Guerra

Piña‐Flores

Zamora‐López

et al. 2020

Influenza Resp Viruses

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Background Respiratory syncytial virus (RSV) is the leading cause of severe acute respiratory infections (ARI) in preterm infants. The incidence of RSV‐associated hospitalizations has not been defined in Mexico. Objectives To determine the incidence of ARI‐ and RSV‐associated hospitalizations in preterm infants during the first year of life. Methods Prospective cohort study of 294 preterm infants followed up through monthly telephone calls and routine outpatient visits. Hospitalized children were identified through daily visits to pediatric wards of participating hospitals and through telephone calls. Respiratory samples were tested for RSV by RT‐PCR. Results Mean gestational age of participating infants was 33 weeks. Ninety‐six infants were diagnosed with bronchopulmonary dysplasia (BPD) and 17 with congenital heart disease (CHD); 11 had both conditions. There were 71 hospitalization episodes in 53 infants. Respiratory samples for RSV detection were available in 44 hospitalization episodes, and the result was positive in 16 (36.3%). At least one hospitalization for ARI was recorded in 33 of 96 participants with BPD, in seven of 17 with CHD, and 18 of 192 infants without these diagnoses. Five (71.4%) of CHD infants who required admission also had BPD. RSV‐confirmed hospitalization rates were 9.4%, 5.9%, and 2.6% for infants with BPD, CHD, and otherwise healthy preterm infants, respectively. Attributable RSV admission frequencies were estimated to be 13.6%, 16.5%, and 4.1%, respectively. Conclusions Mexican preterm infants, particularly those with BPD, have high rates of ARI‐ and RSVassociated hospitalizations. Specific interventions to reduce the incidence of severe infections in this highrisk group are required.

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“…En la población de pretérminos la falta de desarrollo pulmonar podría explicar la mayor susceptibilidad a (7,12,13) infecciones respiratorias .…”

Section: Discussionunclassified

“…Todos estos factores argumentan el (6) elevado riesgo de infecciones . Además, se plantea que los prematuros con déficit de surfactante están más predispuestos a infecciones respiratorias, ya que el surfactante actúa como barrera protegiendo la (7) superficie alveolar de agresiones .…”

Section: Introductionunclassified

Infecciones respiratorias virales en pacientes hospitalizados en una unidad de cuidados intensivos neonatales

Arias

Fonseca

Real

et al. 2019

Pediatr (Asunción).

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Introducción: Las infecciones respiratorias virales constituyen una problemática nacional y las unidades de cuidados intensivos neonatales, no están exentas de estas. Objetivo: Describir la frecuencia y características clínicas de las infecciones respiratorias virales en neonatos internados en un servicio de Neonatología durante el periodo de enero 2017 a octubre 2018. Materiales y Métodos: Estudio observacional, descriptivo, retrospectivo. Fueron analizadas historias clínicas de pacientes hospitalizados en la unidad de cuidados intensivos neonatales, que tuvieron diagnóstico de infecciones respiratorias de origen viral, el método de diagnóstico fue inmunofluorescencia directa, inmunocromatografía y PCR en tiempo real. Se excluyeron pacientes que procedan de otro servicio y hayan iniciado los síntomas antes del ingreso a nuestro centro. Variables: edad gestacional, edad posnatal, peso de nacimiento, síntomas, tipo de virus, prescripción de antibióticos. Los datos fueron analizados con Excel, utilizando estadísticas descriptivas. Resultados: De los 761 pacientes, 65 pacientes presentaron diagnóstico de infección respiratoria viral: frecuencia del 8,5%. EL promedio de edad fue de 17±10 días El método de diagnóstico más frecuente fue inmunofluorescencia 92%, Los síntomas más comunes fueron las secreciones respiratorias (74%) y desaturaciones (64%); Los virus más frecuentes fueron: Sincitial Respiratorio 26%, Influenza B 25%, Influenza A en un 18%. El 66% requirió tratamiento de soporte respiratorio. Un paciente falleció por causas no relacionadas a la infección respiratoria viral. Conclusiones: La frecuencia de infecciones virales fue del 8,5%. Los virus más frecuentes fueron VSR e influenza B. Más de la mitad necesitaron soporte respiratorio. Ningún paciente falleció.

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The impact of respiratory viruses on lung health after preterm birth

Cited by 46 publications

References 138 publications

<p>Impact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6–9 Years</p>

<p>Impact of Prematurity and Severe Viral Bronchiolitis on Asthma Development at 6–9 Years</p>

Respiratory syncytial virus acute respiratory infection‐associated hospitalizations in preterm Mexican infants: A cohort study

Infecciones respiratorias virales en pacientes hospitalizados en una unidad de cuidados intensivos neonatales

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