Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.

Carvalho, Márcia; Ferreira, Pedro J.; Mendes, Vanda; Silva, Renata; Pereira, José Alberto; Jerónimo, Carmen; Silva, Branca M.

doi:10.1016/j.fct.2009.10.043

Cited by 260 publications

(183 citation statements)

References 51 publications

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“…The high positive correlation between phenolic/erythrocyte protective effect (R 2 = 0.931), flavonoids/erythrocyte protective effect (R 2 =0.926) show that phenolic and flavonoid content are the main contributor to the erythrocytes protective effect through their AAPH scavenging activity as show the high correlation between both DPPH and ABTS in one hand and protective effect. Our results are in agreement with other studies showing that polyphenols are able to protect erythrocytes from oxidative stress or increase their resistance to damage caused by oxidants (Carvalho et al, 2010 andMendes et al, 2011).…”

Section: Evaluation Antioxidant Activitiessupporting

confidence: 83%

Antioxidant and Anti-Hemolytic Activities of Phenolic Constituents of Six Moroccan Date Fruit (Phoenix Dactylifera L.) Syrups

Bouhlali¹,

Alem²,

Benlyas³

et al. 2015

JGIASS

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Date fruits are traditionally used to prepare a wide range of products such as vinegar wine, jam and syrup named locally "Tahlawt" moreover, their direct consumption. The aim of this study is to investigate the antioxidant and anti-hemolytic activities of six syrups prepared traditionally form six different date fruit cultivars grown in southeast Morocco. Significant difference(P < 0.05) was established among analysed syrups. The highest phenolic (6.70 g GAE /100g DW) and flavonoid content (932.82 mg RE /100g DW) were found in Jihl syrups which possessed the highest antioxidant activity based on FRAP (9.55 mmol TE/100g DW), ABTS (8.27 mmol TE /100 g DW), DPPH IC50 (381.99 µg/mL) and exhibited the highest membrane protective effect (317.70 min). Tamaajount syrup contains the lowest phenolic (3.72g GAE /100g DW) and flavonoid content (528.19 mg RE /100g DW) and presented the lowest antioxidant activity based on FRAP (5.30 mmol TE/100g DW), ABTS (4.68 mmol TE /100 g DW) and DPPH IC50 (1.095 mg/mL) as well as the lowest membrane protective effect (226.44 min).The results obtained suggest that date fruit syrups could be considered as a functional food or functional food ingredient because of their high phenolic compounds, which act as antioxidants and membrane stabilizer.

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Section: Evaluation Antioxidant Activitiessupporting

confidence: 83%

Antioxidant and Anti-Hemolytic Activities of Phenolic Constituents of Six Moroccan Date Fruit (Phoenix Dactylifera L.) Syrups

Bouhlali¹,

Alem²,

Benlyas³

et al. 2015

JGIASS

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“…A small clinical study in men at risk for prostate cancer showed increased serum γ-tocopherol and a trend towards an increase in the ratio of free prostate specific antigen (PSA): total PSA after eight weeks of a diet supplemented with 75 g walnuts per day compared with a control diet [63]. Two recent experimental studies using human cancer cell lines [64] and a mice model of human breast cancer [65] suggest an antiproliferative effect of walnuts. Clearly, more research is necessary on the important topic of nuts and cancer.…”

Section: Epidemiological Studies Of Nut Consumption and Health Outmentioning

confidence: 99%

Health Benefits of Nut Consumption

2010

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Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension, cancer, and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect, even in the context of healthy diets, and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity and the metabolic syndrome also appear to be positively influenced by nut consumption. Thus it is clear that nuts have a beneficial impact on many cardiovascular risk factors. Contrary to expectations, epidemiologic studies and clinical trials suggest that regular nut consumption is unlikely to contribute to obesity and may even help in weight loss. Safety concerns are limited to the infrequent occurrence of nut allergy in children. In conclusion, nuts are nutrient rich foods with wide-ranging cardiovascular and metabolic benefits, which can be readily incorporated into healthy diets.

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“…31 Moreover, ETs and EA seem to exhibit anticancer properties in vitro and in vivo. Recent research in vitro has shown that walnut extracts have dose-dependent inhibitory effects on colon cancer cell growth 32 and it has been observed that walnuts delay the growth rate of breast cancer cells 33 and prostate cancer cells 30 implanted in mice. ET-rich herbal extracts have been shown to inhibit LNCaP cell proliferation and reduce PSA secretion.…”

Section: Introductionmentioning

confidence: 99%

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

et al. 2014

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Walnuts have been gathering attention for their health-promoting properties. They are rich in polyphenols, mainly ellagitannins (ETs) that after consumption are hydrolyzed to release ellagic acid (EA). EA is further metabolized by microbiota to form urolithins, such as A and B, which are absorbed. ETs, EA and urolithins have shown to slow the proliferation and growth of different types of cancer cells but the mechanisms remain unclear. We investigate the role of urolithins in the regulatory mechanisms in prostate cancer, specifically those related to the androgen receptor (AR), which have been linked to the development of this type of cancer. In our study, urolithins down-regulated the mRNA and protein levels of both prostate specific antigen (PSA) and AR in LNCaP cells. The luciferase assay performed with a construct containing three androgen response elements (AREs) showed that urolithins inhibit AR-mediated PSA expression at the transcriptional level. Electrophoretic mobility shift assays revealed that urolithins decreased AR binding to its consensus response element. Additionally, urolithins induced apoptosis in LNCaP cells, and this effect correlated with a decrease in Bcl-2 protein levels. In summary, urolithins attenuate the function of the AR by repressing its expression, causing a down-regulation of PSA levels and inducing apoptosis. Our results suggest that a diet rich in ET-containing foods, such as walnuts, could contribute to the prevention of prostate cancer.

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Human cancer cell antiproliferative and antioxidant activities of Juglans regia L.

Cited by 260 publications

References 51 publications

Antioxidant and Anti-Hemolytic Activities of Phenolic Constituents of Six Moroccan Date Fruit (Phoenix Dactylifera L.) Syrups

Antioxidant and Anti-Hemolytic Activities of Phenolic Constituents of Six Moroccan Date Fruit (Phoenix Dactylifera L.) Syrups

Health Benefits of Nut Consumption

Walnut polyphenol metabolites, urolithins A and B, inhibit the expression of the prostate-specific antigen and the androgen receptor in prostate cancer cells

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