Human cartilage glycoprotein 39—biomarker of joint damage in knee osteoarthritis

Živanović, Sandra; Rackov, Ljiljana; Vojvodić, Danilo; Vucetic, Dusan

doi:10.1007/s00264-009-0747-8

Cited by 34 publications

(19 citation statements)

References 16 publications

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“…Within OA joints, YKL-40 is secreted into the synovial fluid by chondrocytes, activated macrophages and synovial fibroblasts [16,31]. Different investigations have demonstrated that osteoblasts and osteocytes present in osteophytes expressed YKL-40 [14,18]. Thus, our finding of higher YKL-40 levels in synovial fluid reflects OA changes in the joint tissue.…”

Section: Discussionsupporting

confidence: 58%

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Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

et al. 2018

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The aim of our study was to analyze the level of the glycoprotein YKL-40 in patients with active knee osteoarthritis (OA) and to search possible correlations with local inflammation and ultrasound (US) findings.Material and methods: A prospective study with fifty consecutive patients with active knee OA (diagnosed based on the American College of Rheumatology criteria for OA with radiographic confirmation) was performed. Concentrations of YKL-40 in serum and synovial fluid were measured by ELISA. US examinations – Gray scale (GS) US and Power Doppler (PD) US – of the knee was performed according to international guidelines. The suprapatellar, medial and lateral parapatellar recesses were scanned in each knee to evaluate synovial hypertrophy and vascularization.Results: Forty women (mean age 61.50±11.33 years old) and 10 men (aged 68.50±6.60 years old) were enrolled. We found that the synovial level of the glycoprotein (237.80±104.08 ng/ml) was significantly higher compared to the serum concentration (112.83±60.61 ng/ml, p<0.001). The serum concentration in OA patients was higher comparing with age-matched healthy controls (84.19±11.39 ng/ml) (p<0.05). A statistically significant association between YKL- 40 in synovial fluid and serum levels was shown. We determined a moderately positive linear relationship between the synovial level of the glycoprotein and the serum concentration. No association between the levels of inflammatory markers – erythrocyte sedimentation rate and C-reactive protein – and YKL-40 concentrations was detected. Our study revealed a strong relationship between YKL-40 in synovial fluid and GS US and feeble with PD US. YKL-40 correlated with inflammatory activity in knee joints and neovascularization detected by US.Conclusions: YKL-40 is involved in the pathogenesis of OA synovitis. Evaluation of YKL-40 levels in parallel with US might provide more sensitive and reliable information for the diagnosis and understanding of OA.

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Section: Discussionsupporting

confidence: 58%

“…Most published studies used radiographic examination to assess the disease process in joints. The data available are quite controversial [18][19].…”

Section: Introductionmentioning

confidence: 99%

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

et al. 2018

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“…Tenascin and fibronectin are further molecules which modulate the interactions between chondrocytes and the surrounding microenvironment [47]. Cartilage oligomeric matrix protein (COMP) and other non collagenous proteins are markers of cartilage turnover and degeneration and are upregulated following proinflammatory stimuli [48][49][50].…”

Section: Main Features Of Articular Cartilagementioning

confidence: 99%

Perinatal and Wharton's Jelly-Derived Mesenchymal Stem Cells in Cartilage Regenerative Medicine and Tissue Engineering Strategies

Iacono

Anzalone

Corrao

et al. 2011

TOTERMJ

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Stem cells can be found in embryonic and extraembryonic tissues as well as in adult organs. In particular, research in the last few years has delineated the key features of perinatal stem cells derived from fetus-associated tissues. These cells show multiple differentiation potential, can be easily expanded ex vivo, and raise no ethical concerns as regards their use. Several reports indicate that cells isolated from Wharton's jelly (WJ), the main component of umbilical cord extracellular matrix, are multipotent stem cells that express markers shared by other mesenchymal stem cells (MSC) and give rise to different mature cell types belonging to all three germ layers. Moreover, WJ-MSC display promising hypoimmunogenic and immunomodulatory properties, since they express molecules able to modulate NK cells and expand regulatory T-cell populations.In this review, we focus on the use of perinatal stem cells for regenerative medicine aimed at cartilage repair and regeneration. Cartilage is a specialized connective tissue which has poor regeneration and self-repair capacity in vivo. Traumatic injury or autoimmune processes are among the main causes of cartilage damage and degeneration, for which new hope comes from tissue engineering using stem cells which have undergone chondrocyte-like differentiation. We analyze the in vitro and in vivo data on the use of perinatal stem cells, in particular WJ-MSC, for cartilage regenerative medicine. The high variability of cell sources, the use of different types of scaffolds and matrixes, and the administration of several combinations of growth factors clearly point out the need for further research to optimize this cellular therapy approach and translate the results obtained from bench to clinic.

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“…CHI3L1 was found to be a major secreted protein of human articular cartilage chondrocytes and synovial cells [6,7]. In addition, CHI3L1 has been detected in sera of patients with various diseases including inflammatory bowel disease, pulmonary sarcoidosis, systemic sclerosis, and liver fibrosis [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis

Wang

Cai

et al. 2014

Tumor Biol.

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Increasing evidence demonstrated that chitinase 3-like 1 (CHI3L1) was highly expressed and tightly associated with human tumor development and progression. However, its precise role in non-small cell lung cancer (NSCLC) remains to be delineated. The aim of this study was to examine CHI3L1 expression in patients with NSCLC and explore the relationship of CHI3L1 protein with clinicopathologic factors, tumor angiogenesis, and prognosis. CHI3L1 protein and intratumoral microvessels were examined by immunohistochemical staining in 95 NSCLC patients. Intratumoral microvessel density (MVD) was measured by counting CD34-positive immunostained endothelial cells. Quantitative real-time PCR (qRT-PCR) analyses were used to investigate the CHI3L1 expression status in tissues. Our result showed that CHI3L1 was significantly up-regulated in NSCLC tissues. In addition, univariate and multivariate analysis demonstrated that CHI3L1 protein overexpression and high MVD were significantly associated with tumor relapse. Although CHI3L1 overexpression and high MVD indicated poor overall survival (P < 0.05), multivariate analysis suggested that only CHI3L1 overexpression was an independent prognostic marker for unfavorable overall survival in patients with NSCLC (P < 0.05). The current results demonstrated that CHI3L1 may be a promising biomarker to identify individuals with poor prognostic potential and a possible target for anti-angiogenic therapy in patients with early stage NSCLC.

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Human cartilage glycoprotein 39—biomarker of joint damage in knee osteoarthritis

Cited by 34 publications

References 16 publications

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

Perinatal and Wharton's Jelly-Derived Mesenchymal Stem Cells in Cartilage Regenerative Medicine and Tissue Engineering Strategies

Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis

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