2015
DOI: 10.1002/eji.201445193
|View full text |Cite|
|
Sign up to set email alerts
|

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA‐E during active tuberculosis and express type 2 cytokines

Abstract: CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells typically recognize peptides associated to classical MHC class Ia molecules, but little information is available on CD8 T cells recognizing M. tuberculosis Ags presented by nonclassical MHC class Ib molecules.We show here that CD8 T cells from tuberculosis (TB) patients recognize HLA-E-binding M. tuberculosis peptides in a CD3/TCR αβ mediated and CD8-dependent manner, and represent … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

2
64
2

Year Published

2015
2015
2024
2024

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 62 publications
(68 citation statements)
references
References 56 publications
2
64
2
Order By: Relevance
“…However, stimulating Th1 immunity in TB can also result in excessive inflammation (see Box 1). More recently, the contributions of additional immune pathways have been explored, especially the role of type I interferons (T1-IFNs), Th17 immunity (14, 15), and unconventional T cell immunity (1618). Little is known about the potential interaction between T1-IFNs and Th17 responses in TB, but interesting observations in this regard have been reported for multiple AID (1921).…”
Section: Introductionmentioning
confidence: 99%
“…However, stimulating Th1 immunity in TB can also result in excessive inflammation (see Box 1). More recently, the contributions of additional immune pathways have been explored, especially the role of type I interferons (T1-IFNs), Th17 immunity (14, 15), and unconventional T cell immunity (1618). Little is known about the potential interaction between T1-IFNs and Th17 responses in TB, but interesting observations in this regard have been reported for multiple AID (1921).…”
Section: Introductionmentioning
confidence: 99%
“…MHC-E-restricted CD8+ T cell responses have been previously identified in human CMV (HCMV), Hepatitis C virus (HCV), Mycobacterium tuberculosis (mTB), and Salmonella enterica infections, typically involving epitopes that are structurally related to the canonical MHC-Ia leader sequence peptides, but foreign to the host (13, 14, 19, 20). To determine the extent to which MHC-E restricts RM CD8+ T cell responses in different settings, we used blocking with high affinity MHC-E-binding peptide VL9 [in conjunction with blocking with anti-MHC-II CLIP peptide and anti-MHC-I monoclonal antibody (mAb) W6/32 (6)] to restriction-classify all SIVgag epitope-specific CD8+ T cell responses in RM vaccinated with strain 68-1 (ΔRh157.5/.4) RhCMV/SIVgag vectors, strain 68-1.2 (Rh157.5/.4-repaired) RhCMV/SIVgag vectors, strain 68-1.2 RhCMV/SIVgag vectors from which the Rh157.5/.4 genes were specifically re-excised (fig.…”
mentioning
confidence: 99%
“…HLA-E and Qa-1 bind peptides from bacteria, such as S. typhimurium, S. enterica serovar Typhi, L. monocytogenes , and Mtb (Bouwer et al 1997; Caccamo et al 2015; Lo et al 2000; Salerno-Goncalves et al 2004; van Meijgaarden et al 2015). Interestingly, in the absence of Qdm, a peptide derived from heat shock protein 60 (Hsp60) is primarily loaded into Qa-1 (GMKFDRGYI) (Davies et al 2003).…”
Section: Mhc Class Ib-restricted Cd8+ T Cells and Their Participatmentioning
confidence: 99%
“…This was first proposed when it was determined that the predominant CD8 + T cell response in latently infected patients was MHC class Ia and CD1 independent (Heinzel et al 2002; Lewinsohn et al 2000). The recognition of Mtb --derived peptides presented by HLA-E (Caccamo et al 2015; van Meijgaarden et al 2015) differs from the classically restricted CD8 + T cell response. HLA-E-restricted T cells appear to acquire a Th2 phenotype, producing TNF-α, IL-4, IL-5, IL-10, and IL-13, but have poor cytotoxicity in response to stimulation (Caccamo et al 2015; van Meijgaarden et al 2015).…”
Section: Mhc Class Ib-restricted Cd8+ T Cells and Their Participatmentioning
confidence: 99%
See 1 more Smart Citation