Human chorionic gonadotropin ratio of hemoperitoneum versus venous serum improves early diagnosis of ectopic pregnancy

Peritoneal relative to venous serum biomarker concentrations for diagnosis of ectopic pregnancy

“…An R p/v-hCG value >1 can therefore be considered indicative of EP, whereas R p/v-hCG values ·1 can be considered indicative of intrauterine pregnancy. Based on the Wndings of Wang et al [13] and those of the present report, it is proposed that EP can rapidly and accurately be diagnosed by culdocentesis Wndings of dark-red, non-coagulating blood and an R p/v-hCG value >1.…”

“…Hemoperitoneum develops in response to trophoblastic invasion of blood vessels in EP. A novel diagnostic approach for EP based on hCG concentrations in peritoneal relative to those in venous serum was recently described by Wang et al [13]. When the ratio of intra-abdominal serum hCG to real-time venous serum hCG (R p/v-hCG ) exceeded 1, EP could be distinguished from intrauterine pregnancy with 100% sensitivity and speciWcity.…”

Clinical Application of One-Step Diagnosis for Ectopic Pregnancy by HCG Ratio: Hemoperitoneum Versus Venous Serum

“…Uterine curettage may be useful following endocrine documentation that suggests a nonviable pregnancy regardless of it's location. Wang et al, 2010;Barnhart et al, 1994;Barnhart et al, 2002;Kirk et al, 2007;Stovall et al, 1992;Anonymous., 1992;Dart et al, 2002;Kadar et al, 1988. Other markers (such as vascular endothelial growth factor, creatinine kinase and progesterone) have been studied extensively in relation to ectopic pregnancy but the results have been so conflicting that none have been put into clinical use (Develioglu, et al, 2002.). The clinical utility of these biomarkers is limited because of variable results due, for the most part, to limitations in study design.…”

“…In HCLP, blood in posterior pouch is from ovarian vessels in which the hCG level is near to that of venous serum (Wang, et al, 2010.). The hCG level of venous serum, however, gradually increases as the IUP proceeds.…”

Place de la biologie parmi les stratégies diagnostiques de la grossesse extra-utérine

“…Il apparaît que lors d'une GEU, les concentrations en hCG dans le liquide péritonéal sont supérieures à celles mesurées au niveau plasmatique. Aussi, un rapport hCG péritonéal/hCG plasmatique supé-rieur à 1 oriente vers une GEU [16]. La concentration péritonéale supérieure à la concentration plasmatique peut être expliquée par la proximité entre le site de production des hCG et le sang épanché, d'autre part, par un métabolisme des hCG de l'hémopéritoine différent de celui du sang périphérique.…”