Human Colostrum and Breast Milk Contain High Levels of TNF-Related Apoptosis-Inducing Ligand (TRAIL)

Davanzo, Riccardo; Zauli, Giorgio; Monasta, Lorenzo; Brumatti, Liza Vecchi; Abate, Maria Valentina; Ventura, Giovanna; Rimondi, Erika; Secchiero, Paola; Demarini, Sergio

doi:10.1177/0890334412441071

Cited by 12 publications

(12 citation statements)

References 10 publications

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“…A complex biological liquid containing numerous immunoactive agents might play an important role in the anticancer activity of human breast milk. High levels of human soluble TNF-related apoptosis-inducing ligand were found in human colostrum and breast milk, which is an immunoactive substance that plays a key role in controlling apoptosis and cell proliferation in various organs and tissues (Davanzo et al, 2013). Human alpha-lactalbumin made lethal to tumor cells, which is a substance with anticancer activity in human milk, has been reported (Mossberg et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Breastfeeding and the Risk of Childhood Hodgkin Lymphoma: A Systematic Review and Meta-analysis

Wang¹,

Liu²,

Zhuang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: Numerous observational epidemiological studies have evaluated associations between breastfeeding and the risk of childhood Hodgkin lymphoma; however, the existing results are inconsistent. We therefore conducted a systematic review and meta-analysis. Methods: Medical literature was searched in the Pubmed and Embase databases to identify all English-language relevant studies up to April 10, 2013. Reference lists were thereafter hand-searched for additional articles. Studies that reported relative risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were included. This meta-analysis was conducted in accordance with the guidelines for the meta-analysis of observational studies in epidemiology. Results: We finally included 10 case-control studies in our meta-analysis, involving 1,618 childhood Hodgkin lymphoma cases and 8,181 controls. Overall, we did found a borderline significant association between breastfeeding and reduced risk of childhood Hodgkin lymphoma comparing ever breastfed children to never breastfed children (pooled OR =0.79; 95%CI, 0.58-1.08; P=0.13), with limited evidence for between-study heterogeneity (P =0.12, I 2 = 35.70%). Conclusion: There is limited evidence for an inverse association between breastfeeding and risk of childhood Hodgkin lymphoma.

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Section: Discussionmentioning

confidence: 99%

Breastfeeding and the Risk of Childhood Hodgkin Lymphoma: A Systematic Review and Meta-analysis

Wang¹,

Liu²,

Zhuang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…It may be present either in a trans-membrane form or occur in the cytoplasm as a soluble protein. Extremely high levels of TRAIL have been detected in human colostrum and milk (Davanzo et al, 2012). TRAIL is a pleiotropic cytokine with important functions in regulating immune response and inflammation.…”

Section: Tnf -Related Apoptosis Inducing Ligand (Trail)mentioning

confidence: 99%

“…In case of mammals, maternal milk has paramount preventive and therapeutic benefit against vast variety of diseases, including cancer. Numerous studies in humans testify the immunological potential of human milk (Davanzo et al, 2012;Davis, 1998;Harikrishnan, 2006;Mathur et al, 1993;Newman, 1995;Parodi, 2007;Shamsia, 2009;Singh et al, 2012). The global epidemic of cancer is rising with this disease killing more people across the world than tuberculosis, AIDS, and malaria combined.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of Camel Milk

Dubey

Lal

Mittal

et al. 2016

Emir. J. Food Agric

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“…Using a human prospective birth cohort of 291 healthy term neonates, Belderbos et al [73] reported that breastfeeding significantly modulated innate immune function (e.g., elevated TLR-7 mediated IL-10 cytokine production) compared with formula feeding. Breast milk is also rich in the immunomodulatory, TNF-related, apoptosis-inducing ligand (TRAIL), which is absent in formula [74,75].…”

Section: Breastfeeding and Microbiome Supportmentioning

confidence: 99%

Natural Childbirth and Breastfeeding as Preventive Measures of Immune- Microbiome Dysbiosis and Misregulated Inflammation

Dietert¹

2013

J Anc Dis Prev Rem

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Much of the prior century was spent applying the latest emerging technologies toward managing pregnancy, childbirth, and infant development. The idea was that each change was significantly improving the health of our children across their lifetime. But it is now clear that with several of the adopted practices, there have been unintended consequences. We have run the risk of losing certain distinct advantages that were inherently embedded in ancient cultures and practices. Among these were the microbial-rich experiences of natural childbirth, breastfeeding, and agrarian living. These practices permitted children to acquire a complete microbiome thereby facilitating immune development and appropriate later-life immune responses. Perceived technology-associated benefits such as scheduled Caesarian births, urban sanitized living, and earlier and ever increasing vaccine burdens have helped to reduce the burden of some childhood illnesses. But recent studies suggest that they have also produced serious, unanticipated consequences for today's children: an increased likelihood for human-microbiome incompleteness, lifelong immune dysfunction, and inflammation-promoted chronic disease. This review will examine recent evidence suggesting that a more effective blending of ancient practices and remedies with modern technology and medical knowledge could help to restore the human-microbiome super organism to its historic status, improve pediatric immune homeostasis and reduce risk of later-life chronic diseases.historic birth and infant feeding practices. As discussed by Wolf [4], there is an irony that early in the 20 th century public health officials were advocating increased breastfeeding by mothers and early in the 21 st century the same exact message has been repeated albeit with a different mix of reasons [4]. In the case of the 20 th century call for increased breastfeeding, the primary health concerns were for acute illnesses such as diarrheal diseases, pneumonia, and necrotizing colitis [4]. But for the more recent call, the preventative focus is larger and includes the prevention of noncommunicable chronic diseases (NCDs) [5]. This review considers: 1) shifting historic views regarding the value of natural childbirth and breastfeeding as preventive measures, and 2) an emerging paradigm in which natural childbirth (NC) and prolonged infant breastfeeding combine to reduce the risk of inflammation-driven chronic diseases via immune-microbiome co-maturation as well as other possible developmentally-programmed routes. Additionally, NC and breastfeeding are discussed under the broader human ecological framework of a developmental model in which effective humanmicrobe super organism formation between the child's mammalian component and symbiotic microbes that form the child's microbiome, termed the "Completed Self " [6]. Timely, complete and individualized formation of this symbiotic human mammalian-microbial organism or "Completed Self " has been suggested as perhaps the single most important biological sign con...

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Human Colostrum and Breast Milk Contain High Levels of TNF-Related Apoptosis-Inducing Ligand (TRAIL)

Abstract: Human soluble TRAIL is present at extremely high levels in human colostrum and human milk and might have a significant role in mediating the anti-cancer activity of human milk.

Cited by 12 publications

References 10 publications

Breastfeeding and the Risk of Childhood Hodgkin Lymphoma: A Systematic Review and Meta-analysis

Breastfeeding and the Risk of Childhood Hodgkin Lymphoma: A Systematic Review and Meta-analysis

Therapeutic potential of Camel Milk

Natural Childbirth and Breastfeeding as Preventive Measures of Immune- Microbiome Dysbiosis and Misregulated Inflammation

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