Human Coproantibody Against Polioviruses*

Lipton, Murray M.; Steigman, Alex J.

doi:10.1093/infdis/112.1.57

Cited by 21 publications

(11 citation statements)

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“…The presence of serum proteins and antibody activity against a variety of bacteria and viruses has been described in certain human secretions and excretions: vaginal (2, 3), salivary (4,5), intestinal (6), prostatic (7), urine (8,9), and feces (10,11). The capacity of human nasal secretions to inactivate viruses was first described by Amoss and Taylor in 1917 (12) and confirmed by Howitt in 1937 (13).…”

mentioning

confidence: 95%

Serum Proteins and Antibody Activity in Human Nasal Secretions *

Remington¹,

Vosti²,

Lietze³

et al. 1964

J. Clin. Invest.

114

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mentioning

confidence: 95%

Serum Proteins and Antibody Activity in Human Nasal Secretions *

Remington¹,

Vosti²,

Lietze³

et al. 1964

J. Clin. Invest.

114

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“…Other investigators [4,6,8,9,12] reported that coproantibody against poliovirus appeared in feces of patients or vaccinees, suggesting that this might contribute to the intestinal resistance. According to these reports, the presence of coproantibody was not constant, and its titer was low.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Resistance in the Experimental Enteric Infection of Mice with a Mouse Adenovirus

Hashimoto

Sugiyama

Yoshikawa

et al. 1970

Japanese Journal of Microbiology

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Investigation was made on the process of enteric infection with mouse adenovirus strain K87 in inbred DK1 mice and the intestinal resistance acquired through infection. The cells containing viral antigens were enumerated in most parts of the infected intestinal tract by a fluorescent antibody technique, and the infectivity titer of the virus in each part was examined in mouse kidney tissue culture. The virus was observed to grow in 3~14 days (sometimos 3~21 days) after oral challenge, and infectivity titers reached their peak after 7~14 days, when a number of viral antigen‐containing cells and cells with nuclear inclusions were detected. In the mice rechallenged 28 days after the initial challenge, the virus did not grow, and no viral antigen‐containing cells were found. From these results it was concluded that the main sites where the virus grows in mice are the cells which are scattered in the epithelial layer of the mucous membrane of the small intestine, and which seem to be the usual epithelial cells and not Paneth's or goblet cells. As for intestinal resistance, experiments with inactivated vaccine and with passive transfer of serum‐antibodies were performed in order to find out whether neutralizing antibodies in the serum had any influence on the growth of virus in the intestinal wall, and no influences were indicated. Eighteen days or more after challenge, K87 virus‐neutralizing substances were detected in the intestinal wall and in the intestinal contents of the infected mice, but not in the serum‐transferred mice, though both groups of mice had equal levels of serum antibodies. The substance continued to be found until 15 weeks after challenge in the intestinal contents, and until later than 34 weeks in the intestinal walls. The nature and the possible role of the substance is discussed, but actual data will be reported in subsequent papers.

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“…In studies on poliovirus coproantibody in man, Lipton and Steigman [14] and Kono et al [13] reported that the neutralizing substance in fecal extracts had a nature characteristic of gamma-globulin. [10], and Keller et al [11] showed that the poliovirus-neutralizing activity in fecal extracts of man was associated with IgA and also with antibody fragments, by DEAE-cellulose chromatography and Sephadex G-200 gel-filtration, or by examining the fecal extracts of newborn infants which usually contained no IgA.…”

Section: Discussionmentioning

confidence: 99%