Human Coronavirus-NL63 Infection is not Associated with Acute Kawasaki Disease

Baker, Susan C.; Shimizu, Chisato; Shike, Hiroko; Garcia, Francesca L.; Hoek, Lia van der; Kuijper, Teun; Reed, Sharon L.; Rowley, Anne H.; Shulman, Stanford T.; Talbot, H. Keipp; Williams, John V.; Burns, Jane C.

doi:10.1007/978-0-387-33012-9_94

Cited by 16 publications

(14 citation statements)

References 8 publications

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“…77 However, no subsequent study has been able to confirm this association. [78][79][80][81][82] HCoV-229E has been suggested as the causative agent of multiple sclerosis. [83][84][85][86] Some research groups have found a higher frequency of HCoV-229E in the brains of patients with multiple sclerosis compared to a control group.…”

Section: Disease Association Of Hcov-nl63 and Hcov-229ementioning

confidence: 99%

Human Coronaviruses 229E and NL63: Close Yet Still So Far

Dijkman

Hoek

2009

Journal of the Formosan Medical Association

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HCoV-NL63 and HCoV-229E are two of the four human coronaviruses that circulate worldwide. These two viruses are unique in their relationship towards each other. Phylogenetically, the viruses are more closely related to each other than to any other human coronavirus, yet they only share 65% sequence identity. Moreover, the viruses use different receptors to enter their target cell. HCoV-NL63 is associated with croup in children, whereas all signs suggest that the virus probably causes the common cold in healthy adults. HCoV-229E is a proven common cold virus in healthy adults, so it is probable that both viruses induce comparable symptoms in adults, even though their mode of infection differs. Here, we present an overview of the current knowledge on both human coronaviruses, focusing on similarities and differences.

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Section: Disease Association Of Hcov-nl63 and Hcov-229ementioning

confidence: 99%

Human Coronaviruses 229E and NL63: Close Yet Still So Far

Dijkman

Hoek

2009

Journal of the Formosan Medical Association

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“…2 In the meantime, this observation has been rejected by other investigators. [10][11][12][13] We report the first case of an acute life threatening event (ALTE) in an infant with human coronavirus HCoV-229E infection.…”

Section: Introductionmentioning

confidence: 99%

Acute life threatening event (ALTE) in an infant with human coronavirus HCoV‐229E infection

Simon

Völz

Höfling

et al. 2007

Pediatric Pulmonology

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In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT-PCR confirmed coronavirus HCoV-229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR-based techniques should be utilized to increase the sensitivity of detection for old and new respiratory viral pathogens in comparable cases.

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“…In a case-controlled study of young German children it was reported that the chance of croup is 6.6 times higher in NL63-positive children than in NL63-negative children Konig et al, 2004). Also, a link between NL63 and Kawasaki disease has been suggested , but other groups recently questioned this association (Belay et al, 2005;Ebihara et al, 2005b;Shimizu et al, 2005;Baker et al, 2006;Chang et al, 2006).…”

Section: Human Coronaviruses Nl63 and Hku1mentioning

confidence: 99%

Emerging respiratory agents: New viruses for old diseases?

Sloots

Whiley

Lambert

et al. 2008

Journal of Clinical Virology

111

102

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The recent advances in molecular technology have enabled the detection of several new viral agents in specimens collected from the human respiratory tract. Human metapneumovirus was first described in 2001, and is a significant respiratory pathogen, particularly of children. Following the identification of severe acute respiratory syndrome (SARS) associated coronavirus, two other newly detected coronaviruses, NL63 and HKU1, have been linked to respiratory disease in humans. However, identifying a new virus as the causative agent of a specific disease is difficult, and ideally would involve satisfying Koch's postulates. The recently described human bocavirus and polyomaviruses KI and WU have been detected in samples collected from humans with acute respiratory infection, but as yet, have not been conclusively proven to be agents of human disease. We review the new viral agents that have been detected in respiratory samples since 2001, and examine their contribution as agents of human disease.

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Human Coronavirus-NL63 Infection is not Associated with Acute Kawasaki Disease

Cited by 16 publications

References 8 publications

Human Coronaviruses 229E and NL63: Close Yet Still So Far

Human Coronaviruses 229E and NL63: Close Yet Still So Far

Acute life threatening event (ALTE) in an infant with human coronavirus HCoV‐229E infection

Emerging respiratory agents: New viruses for old diseases?

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