Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes

Wang, Hankun; Peng, Weijian; Wang, Jialin; Zhang, Chunyu; Zhao, Wangchun; Ran, Yanhong; Yang, Xiaoping; Chen, Jun; Li, Hongjian

doi:10.3390/v15041014

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…H. Wang et al показали, что мембранный белок цитомегаловируса UL23 регулирует экспрессию многих IFN-стимулируемых генов за счет активации APOL1 (аполипопротеин-L1), CMPK2 (цитидин/уридинмонофосфаткиназа 2) и LGALS9 (галектин-9), и мутации в тегументе цитомегаловируса, связанные с недостаточностью белка UL23, снижают противовирусный эффект IFN-γ [66]. Схожие исследования по активности белков тегумента вируса Эпштейна -Барр (EBV) для экспрессии IFN показали S. Jangra et al Белок BGLF2 тегумента EBV, служащий супрессором сигналов JAK/STAT, приводит к деградации K48-связанного полиубиквитинирования протеасомного пути p38 и JNK.…”

Section: герпесвирусные инфекцииunclassified

Interferon gamma as a trigger of chronic viral infections and inflammatory dermatoses

Evdokimov,

Svechnikova,

Ponezheva

2024

Medicinskij sovet

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Interferon-gamma (IFN-γ) is the only representative of the type II interferon family regulating Th1 and Th2 immune responses. The discovery of IFN-γ is associated with the name of E. Frederick Wheelock. The expression of the IFNG gene provides a pleiotropic effect for IFN-γ, the main immune directions of this cytokine are antiviral, antibacterial and antiprotozoal. Unfortunately, in publications devoted to the relationship between the severity of inflammatory dermatoses (psoriasis, seborrheic dermatitis, atopic dermatitis) and levels of interferon gamma production, there is no consensus on the direct unity of these events. Although in most cases with acute viral diseases, an increase in interferon production is noted at the initial stages, but in some acute respiratory viral infections, its increase is not recorded (COVID-19, etc.), in cases of chronic viral diseases caused by retroviral infections – human immunodeficiency virus, human type 1 T-lymphotropic virus and endogenous human retroviruses as a result of prolonged exposure to IFN-γ on tissues, their damage may be noted, as well as a change in the functional state of CD4+ T cells. In cases of diseases caused by the herpes simplex virus 2, IFN-γ also has a complex effect on the intercellular relationships of infected and uninfected keratinocytes, as well as on the processes of apoptosis in Langerhans cells migrating to the dermis, which causes a violation of CD4+ and CD8+ involvement in the focus+ T-lymphocytes. In autoimmune diseases, IFN-γ can have a multidirectional effect. In particular, in patients with multiple sclerosis, IFN-γ regulates the processes of neuroinflammation and, depending on the concentration, can either reduce the number of CD11b+ myeloid cells of the central nervous system and reduce the infiltration of inflamed cells and normalize the processes of demyelination, or with an increase in IFN-γ production lead to reverse effects. At the same time, an enhancement of IFN-γ for transcription factors of differentially expressed genes in the case of systemic lupus erythematosus in patients has been proven.

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Section: герпесвирусные инфекцииunclassified

Interferon gamma as a trigger of chronic viral infections and inflammatory dermatoses

Evdokimov,

Svechnikova,

Ponezheva

2024

Medicinskij sovet

View full text Add to dashboard Cite

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The battle between host antiviral innate immunity and immune evasion by cytomegalovirus

Li,

Xie,

et al. 2024

Cell. Mol. Life Sci.

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Cytomegalovirus (CMV) has successfully established a long-lasting latent infection in humans due to its ability to counteract the host antiviral innate immune response. During coevolution with the host, the virus has evolved various evasion techniques to evade the host’s innate immune surveillance. At present, there is still no vaccine available for the prevention and treatment of CMV infection, and the interaction between CMV infection and host antiviral innate immunity is still not well understood. However, ongoing studies will offer new insights into how to treat and prevent CMV infection and its related diseases. Here, we update recent studies on how CMV evades antiviral innate immunity, with a focus on how CMV proteins target and disrupt critical adaptors of antiviral innate immune signaling pathways. This review also discusses some classic intrinsic cellular defences that are crucial to the fight against viral invasion. A comprehensive review of the evasion mechanisms of antiviral innate immunity by CMV will help investigators identify new therapeutic targets and develop vaccines against CMV infection.

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Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review

Zeng

Cao

Yang

et al. 2023

Viruses

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Human cytomegalovirus (HCMV) is a widespread pathogen that poses significant risks to immunocompromised individuals. Its genome spans over 230 kbp and potentially encodes over 200 open-reading frames. The HCMV transcriptome consists of various types of RNAs, including messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and microRNAs (miRNAs), with emerging insights into their biological functions. HCMV mRNAs are involved in crucial viral processes, such as viral replication, transcription, and translation regulation, as well as immune modulation and other effects on host cells. Additionally, four lncRNAs (RNA1.2, RNA2.7, RNA4.9, and RNA5.0) have been identified in HCMV, which play important roles in lytic replication like bypassing acute antiviral responses, promoting cell movement and viral spread, and maintaining HCMV latency. CircRNAs have gained attention for their important and diverse biological functions, including association with different diseases, acting as microRNA sponges, regulating parental gene expression, and serving as translation templates. Remarkably, HCMV encodes miRNAs which play critical roles in silencing human genes and other functions. This review gives an overview of human cytomegalovirus and current research on the HCMV transcriptome during lytic and latent infection.

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Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes

Cited by 3 publications

References 46 publications

Interferon gamma as a trigger of chronic viral infections and inflammatory dermatoses

Interferon gamma as a trigger of chronic viral infections and inflammatory dermatoses

The battle between host antiviral innate immunity and immune evasion by cytomegalovirus

Insights into the Transcriptome of Human Cytomegalovirus: A Comprehensive Review

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